Basic Information

Insect: Drosophila grimshawi
Gene Symbol: ush
Assembly: GCA_018153295.1
Location: JAECXY010001376.1:10415042-10478171[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.04 2.6 8.4 0.0 1 20 191 210 191 212 0.89

2 9 0.00023 0.015 15.4 0.8 1 23 267 289 267 289 0.98

3 9 0.042 2.7 8.4 1.0 2 21 340 359 340 360 0.92

4 9 0.029 1.9 8.9 3.0 2 21 704 723 703 724 0.93

5 9 0.0075 0.49 10.7 0.0 3 21 774 792 772 793 0.91

6 9 0.015 1 9.7 0.0 2 23 863 884 862 884 0.98

7 9 0.0032 0.21 11.9 1.3 1 23 890 912 890 912 0.99

8 9 0.001 0.066 13.4 1.8 1 23 938 961 938 961 0.96

9 9 0.25 16 5.9 0.7 2 20 1071 1089 1070 1091 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.04	2.6	8.4	0.0	1	20	191	210	191	212	0.89
2	9	0.00023	0.015	15.4	0.8	1	23	267	289	267	289	0.98
3	9	0.042	2.7	8.4	1.0	2	21	340	359	340	360	0.92
4	9	0.029	1.9	8.9	3.0	2	21	704	723	703	724	0.93
5	9	0.0075	0.49	10.7	0.0	3	21	774	792	772	793	0.91
6	9	0.015	1	9.7	0.0	2	23	863	884	862	884	0.98
7	9	0.0032	0.21	11.9	1.3	1	23	890	912	890	912	0.99
8	9	0.001	0.066	13.4	1.8	1	23	938	961	938	961	0.96
9	9	0.25	16	5.9	0.7	2	20	1071	1089	1070	1091	0.91

Sequence Information

Coding Sequence: ATGTCACGACGCAAACAGTCGAATCCAAAGCCGTTGAATAAAGATTCCAAAGAATTGGCCGCACACGAGCTGAGCGAGGAGAAGCAACAGCAACACCAGCAGCACCAACAACAACAACAGCAACAGCTCGAGGATCAGGCCGAAGACGAGCAGTTAGAGCAACAGTCGAACAACTCCTCCTTGCAACCCGTCGAGACTGACATGGAACAGGAACTGGAGGAGGCGCAAGCGGCAGCCCAGGATTCCAGCGACCAGAAGTTGGCGGACAACCCGACCACGACAACGCCGCCGCGCAGCCCAACGCCTGGAGAACTGGTGCCAAAGCTGGAGAGAGCTGATACGCCTCCCTCAGTTCCAGTCACGCCCAGTCCACCACCGCGCACGCCCACACCACCGCCAATTGTACTGCCCAAGCTGCGACTCAATGCGTTGCTTGCCTCAGATCCGGCATTGAAGCCCGATGCCAAGGAGCTCAATTTGCACGAGTCACGACTGCTGGGTCCACCGCCCAAGCCAGAGCAGCAGCCGACTCTGCAGCCGGATGTGGAGCCGCTGTTGAAACCGGCGCGATTTATGTGCCTGCCGTGCAGCATTGCTTTCAGTTCACCATCAACGCTGGAGGCGCATCAGGCCTACTACTGCTCCCATCGCAACAAGGATGCTGAGGAGGAGACAAACGCTGCCGGTGATAAGGTCACATCCAACAGCGGTGGCACCTCCAATGCCAACAGCAGCTCCAGTGGCTCAACTGCCGCCGGCTCCGAGCCGCCCAACAAGATGTCCCGCATTGGCAAGCAATATGCGTGCACCCAGTGCTCCTACAGTGCCGACAAGAAGGTCTCCCTCAATCGACACATGCGCATGCATCAAACATCCCCAGCGGCACCCAGCCTAAACAGCCTCTCCAGCTTGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATCCGCTTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCAGCGATGGACAACTGACGCCCAAGCCGGAGGCGGGTGGCATCACTGCAATGGTTGCTGCTGCCGCCGCCGCAGCTGCGGCTGCTGCTGCCTCGCTGCAGGTGGCACCACCGCAACCCTTCCTAGCGCTGCCCACTAATCCGATTATCATAGTGCCCTGCTCGCTTATACGTGCTGCCAGCTTGATACCGGGACCACTCACCACTTCTACGTCGGGCATTGTGAATCCGGAGTCCACATGCTTCACGCTCGACAATGGCGCTCTGAAGCCTCTAGCCACGGCTTTAAACATAAATACGCTAGGGGGCAGTGCCACGCCTACGCCTACGCCTATGCCCAGCAGCAATCAGATACCGATGCCCGCTTTAGAGCCAGATCGTCCAACTCCTGTGAGCATTTCGAGCAACCTGGAAACTGAACCCAAGAAAAGTCCAGCAGAACCCAAGCGCAAGGAAACAAGCGGCATACGTGAGACGACGCCACTGGATTTATCGCTAAGACGCTCGCCAATCGCAGCGCTGTTGCAGCGCCAGCGTCTGGCGCGCTCTGCCGCTGCATTGCTCGACGCCGAGGATGCTGCAGGTAAGGATGCTCACTTGGAGAGCATCAGTGGCGGCAGCGTTACACCCGAGCAAATTGTTTGCGCTCCCTCGCTGCCCAGCAGCCCCTCGATGAGTCCCTCACCCAAGCGACGTGCTTTAAGTCCACGCAGCTCTGGAGCTGGCAGCGCTTCGTCGATGTCACCGCCAGCCCATCATATGCTGGATAATTTGCCGCCGTTGCGCTCCATGCTGCCCTCCGATTTTAATCTCTCCGAATCGCTGCTGGCCAAAACGAATCCAGAGTTGGCCCTCAAACTGGCTGCGGCAGCAGCGGCTGCTGTGGCTGGCAGTGGCTCGGTGGAGCTGGCCAAACTAGGATTTCCAGGAGCTGGTGCAGCACCCAGCAGTAGTGCTGCTGCACCATCCTCTGCACAGAATGCACCGCAGATCTATGTGAAGCAGGGCGTCTCCAAGTGCAAGGACTGCAACATTGTCTTCTGCAAATATGAGAATTACTTGGCGCACAAGCAACATTATTGCTCGGCACGCAACCAGGAGACGGGTCTGGATGGAGATGCCTCCAAAAGCGCTGTAACGCCTCCCAGTGGACTATCATCAGTTGGCGGCAATGCTGGCGCCTCCTCTGCAGAAACCACTCCCGTTGCCTATCAGCAACTAATATGCGCCGCCTGCGGCATTAAATACACCTCGCTGGATAATTTGCGTGCGCATCAGAATTACTACTGTCTGAAAGGAGGCGTTGCGGCAGCTGCCACGCCAGCTGAGGCAGCACCAGCACCACAACTGCCACTCGCCCATCCCAAGGAGAAGTGCCCGAAATGCAAGACTCATCATGAGCACGGACAGAATTGTCCACCACCCCCACCACCAGCAACTCCACAACTGCCTGCTCCCTGCTCCACCTCTGCCACGTCGAATAGTGTCAATAAATGTCCCGTTTGTGGCGTAATTAGTCCCACTGCTGCTCTCGCCCGCAAGCACATGGAGATGCATGGAACGGTGAAGGCTTTTCGCTGCTCCATTTGCCAGTATAAAGGGAACACTCTCCGCGGGATGCGCACCCACATTCGCACCCATTTCGATAAGAAGACCAGCGATGTGAACGAGGAGCATTACATGACATGCATCTTTGAGGAGGATGCTGCGACGCTCTTCAATTGCGATCATTGCAATTATGCCTCATCCTACAAGGGCAATGTGCTGCGTCACATGAAATTACTGCATCCACATGTGGCCATTAGTTCGCCCTCCATTTCACCTGAGTCGCGCGAACACGAAGCCAATTCACACGCCCTACCCGAAGTAGCGCTGGTTAATGGGGAACGGGAGGCAGCAGCTGTGCCCAGCTTTCACATTAAAACGGAGGCGTTGGAGGCACCGGTGGCCACATTGAGTCTGGTGCATGAGAACAATAATTCACCCATTGGCACGCCACTTACCCACATTAAAGCGGAGCCCATGGAACTTGGAGTAGATGTATCAGTACCATCGCTACCCCCGCCGATAGCCAATTCCCCGCTTGGGCCGAGCGCAGCGGAGGCATTGAAAAAATACTGCTCCACCTGCGACATATCCTTCAACTATGTGAAGACATTTCTGGCGCACAAGCAATTCTACTGCAAGAGCAAACCGCATCGACCCGAGGCAAATGATAGCCCCAGTCCCACGGTGGGTGGTGGCGTCTCAATGCCGCTGCAGTCGCCCAGCGAGCTGCTGTTGCTCCAGAAGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MSRRKQSNPKPLNKDSKELAAHELSEEKQQQHQQHQQQQQQQLEDQAEDEQLEQQSNNSSLQPVETDMEQELEEAQAAAQDSSDQKLADNPTTTTPPRSPTPGELVPKLERADTPPSVPVTPSPPPRTPTPPPIVLPKLRLNALLASDPALKPDAKELNLHESRLLGPPPKPEQQPTLQPDVEPLLKPARFMCLPCSIAFSSPSTLEAHQAYYCSHRNKDAEEETNAAGDKVTSNSGGTSNANSSSSGSTAAGSEPPNKMSRIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAAPSLNSLSSLXXXXXXXXXXXXXXXXXXXXXXXXXEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEAGGITAMVAAAAAAAAAAAASLQVAPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINTLGGSATPTPTPMPSSNQIPMPALEPDRPTPVSISSNLETEPKKSPAEPKRKETSGIRETTPLDLSLRRSPIAALLQRQRLARSAAALLDAEDAAGKDAHLESISGGSVTPEQIVCAPSLPSSPSMSPSPKRRALSPRSSGAGSASSMSPPAHHMLDNLPPLRSMLPSDFNLSESLLAKTNPELALKLAAAAAAAVAGSGSVELAKLGFPGAGAAPSSSAAAPSSAQNAPQIYVKQGVSKCKDCNIVFCKYENYLAHKQHYCSARNQETGLDGDASKSAVTPPSGLSSVGGNAGASSAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCLKGGVAAAATPAEAAPAPQLPLAHPKEKCPKCKTHHEHGQNCPPPPPPATPQLPAPCSTSATSNSVNKCPVCGVISPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDAATLFNCDHCNYASSYKGNVLRHMKLLHPHVAISSPSISPESREHEANSHALPEVALVNGEREAAAVPSFHIKTEALEAPVATLSLVHENNNSPIGTPLTHIKAEPMELGVDVSVPSLPPPIANSPLGPSAAEALKKYCSTCDISFNYVKTFLAHKQFYCKSKPHRPEANDSPSPTVGGGVSMPLQSPSELLLLQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538480;
90% Identity: iTF_00570666;
80% Identity: -