Basic Information

Insect: Drosophila nigritarsus
Gene Symbol: ush
Assembly: GCA_035044305.1
Location: JAWNMF010000133.1:15155817-15161270[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.052 3.9 8.3 0.0 1 20 215 234 215 236 0.89

2 9 0.0003 0.023 15.3 0.8 1 23 291 313 291 313 0.98

3 9 0.054 4 8.2 1.0 2 21 363 382 363 383 0.92

4 9 0.037 2.8 8.8 3.0 2 21 760 779 759 780 0.93

5 9 0.0097 0.72 10.6 0.0 3 21 830 848 828 849 0.91

6 9 0.02 1.5 9.6 0.0 2 23 919 940 918 940 0.98

7 9 0.0041 0.31 11.8 1.3 1 23 946 968 946 968 0.99

8 9 0.0013 0.098 13.3 1.8 1 23 1033 1056 1033 1056 0.96

9 9 0.33 24 5.8 0.7 2 20 1166 1184 1165 1186 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.052	3.9	8.3	0.0	1	20	215	234	215	236	0.89
2	9	0.0003	0.023	15.3	0.8	1	23	291	313	291	313	0.98
3	9	0.054	4	8.2	1.0	2	21	363	382	363	383	0.92
4	9	0.037	2.8	8.8	3.0	2	21	760	779	759	780	0.93
5	9	0.0097	0.72	10.6	0.0	3	21	830	848	828	849	0.91
6	9	0.02	1.5	9.6	0.0	2	23	919	940	918	940	0.98
7	9	0.0041	0.31	11.8	1.3	1	23	946	968	946	968	0.99
8	9	0.0013	0.098	13.3	1.8	1	23	1033	1056	1033	1056	0.96
9	9	0.33	24	5.8	0.7	2	20	1166	1184	1165	1186	0.91

Sequence Information

Coding Sequence: ATGGGGGAGAAGTGGGCGCGGTCAACGCGCATTGGCGGCCCGCACGAGAAGAAGAcgaagcagaagaagcagaaactCTTTGAGCTTATCGGCGCCTTCATATCTATCGCAGCCATGTTCTATTCCAAAGAATTGGCCGCACACGAGCTGAGCGAggagaagcaacagcaacaccagcagcaccaacaacaacagcaacagctcgAGGATCAGGCCGAAGACGAGCAGTTAGAGCAACAGTCGAACAACTCCTCCCTGCAACCCGTCGAGACTGACATGGAACAGGAGCTGGAGGAGGCACAAGCGGCAGCCCAGGATTCCAGCGAACAGAAGTTGGAGGATAACCCGACAATGACAACGCCGCCGCGTAGCCCATCGCCCGAACTGGTGCCCAAGCTGGAGCGAGCTGATACGCCGCCCTCAGTTCCGGTCACGCCCAGTCCACCACCGCGTACGCCCACACCGCCGCCAATTGTGCTGCCCAAGCTGCGACTCAATGCGTTGCTTGCCTCCGATCCGGCATTGAAGCCCGATGCCAAGGAGCTCAATCTGCACGACACACGACTGCTGGGTCCACCGCCCAAGCCGGAGCAGCAGCCGAGCCTGCAGCCGGATGTGGAACCGCTGCTGAAACCGGCGCGATTTATGTGCCTGCCCTGCAGCATCGCTTTCAGTTCACCCTCAACGCTGGAGGCGCATCAGGCCTACTACTGCTCCCATCGCAACAAGGATGCTGAGGAGGAGACAAACGCTGCCGGTGATAAGGTGACATCCAACAGCGGTGGCACCTCCAATGCCAACAGCAGCTCCAGCGGCTCAAGTGCTACCGGCTCCGAGCCACCCAACAAGGTGTCTCGCATTGGCAAACAGTATGCGTGCACGCAGTGCTCCTACAGTGCCGACAAAAAGGTCTCCCTCAATCGACACATGCGCATGCATCAAACATCCCCAGCGGCACCCAGCCTAAACAACCTCTCCAGCTTGACAGCAAATGGTGTTGTTGCCgcggctgctgccgccgccgcggcagctgctgctgctgctggtgcgcAGCTCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATTCGCTTCAACAACATCAAGACCTACCGGGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCAGCGACGGACAACTGACGCCCAAGCCGGAGGCGGGTGGCATCACTGGAAGTGGAGTTggtggagctggagctggtggtggaggtggagctatatcagttgctgctgttgctgccggcAAGCACAGTCCACAGACGCGCAACAAGACGCCAACGCCAGCaatggttgctgctgccgccgccgcggctgctgctgcctcgctGCAGGTGGCACCACCGCAACCCTTCCTAGCGCTGCCCACCAATCCAATTATCATAGTGCCCTGCTCGCTAATACGTGCAGCCAGCTTGATACCGGGACCACTCACCACCTCTACGTCGGGCATTGTGAATCCGGAGTCCACATGCTTCACGCTCGACAATGGCGCTCTGAAGCCTCTAGCCACAGCTCTAAACATAAATACGTTAGGGGGCAGTGCCACGCCTACGCCTATGCCTAGCAGCAATCAGATACCGATTCCCGCTTTAGAGCCAGATCGTCCAACCCCTGTGAACATTTCAAGCAACCTGGAAACGGAACCCAAGAAAAGTCCACCAGAACCCAAGCGCAAGGAAATAAGCGGCATACGTGAGACGACACCCCTGGATTTATCGCTGAGGCGCTCGCCAATCTCTGCGCTATTGCAGCGCCAGCGTCTCGCGCGCTCTGCCGCTGCGCTGCTGGATGCCGAAGATGCAGCAGGCAAGGATGCTCACTTGGAGAGCATCAGTGGCGGCAGCGTTACACCCGAGCAAATTGTTTGCGCTCCCTCGCTACCCAGCAGCCCCTCGATGAGCCCCTCACCAAAGCGACGTGCTTTAAGTCCACGCAGCTCGGGAGCTGGGAGCGCTTCGTCGATGTCACCGCCAGCCCATCATCTACTGGATAATTTGCCGCCGTTGCGCTCCATGCTGCCCTCCGACTTTAATCTCTCCGAATCGCTGCTGGCCAAAACGAATCCAGAGCTGGCCCTCAAACTAGCcgcggcagcagcggctgctgtaGCAGGCAGTGGCTCGGCGGAGCTGGCCAAACTAGGATTTCCAGGAGGTAGTGCAGCAACCAGCAGTGGTGCTACTGCACCATCCTCTGCACAGAATGCACCGCAGATCTATGTGAAGCAGGGCGTCTCTAAGTGTAAGGACTGCAATATTGTATTCTGCAAATATGAGAATTATTTGGCGCACAAGCAACATTATTGCTCGGCACGAAACCAGGAGACGGGCCTGGATGGAGATGCCTCCAAGAGCGCTGTAACGCCCCCCAGTGGACTATCGTCAGTTGGCGGTAATGCTGGCGCCTCCTCTGCAGAAACCACTCCCGTTGCCTATCAGCAACTAATATGCGCCGCCTGCGGCATTAAGTACACCTCGCTGGATAATTTGCGTGCGCATCAGAATTACTACTGTCTGAAAGGCGgcgctgcggctgctgccacGCCAGCTGaggcagcaccagcaccacaaCTGCCACTCGCCCATCCCAAGGAGAAGTGCTCGAAATGCAAGACTCATCATGAGCACGGACAGAATTGTccaccacctccaccaccGGCAACTCCACAACTGCCTGCTCCCTGCTCCACCTCTGCCACGTCGAATAGTGTCAATAAGTGTCCCGTTTGTGGAGTAATTAGTCCCACTGCTGCCCTCGCCCGCAAGCACATGGAGATGCATGGAACGGTGAAGGCTTTTCGCTGCTCCATTTGCCAGTATAAAGGGAACACTCTCCGCGGGATGCGCACCCACATTCGCACCCATTTCGATAAGAAGACCAGCGATGTGAATGAGGAGCACTACATGACATGCATCTTTGAGGAAGATgctgcagcagtggcagcaacagttgctgctccAACTCAATCCTTGAATCTAGATCTGCCCGCtgtggcagcggcggcggcggcagcagcagcagctcaagaGCAACTGGAACAGCATCCGGCACAGCTCTTCAATTGCGATCATTGCAATTATGCCTCATCCTATAAGGGCAATGTGCTGCGTCACATGAAATTACTGCATCCGCATGTGGCCATTAGTTCGCCCTCCATTTCACCCGAGTCGCGCGAACACGAAGCCAATCCTCATGCCCTACCCGAAATATCGCTGGTTAATGGGGAACGGGAGGCAGCATCTATGCCCAGCTTCCACATTAAAACGGAGGCATTGGAGGCACCGGTGGCCACATTGAGTCTGGTGCATGAGAACAACAATTCACCCATTGGCACACCACTTACCCACATTAAAGCAGAGCCAATGGAACTTGGTGTAGATGTATCAGTACCGTCTCTACCCCCGCCGATGGCCAACTCCCCGCTTGGGCCGAGCGCAGCCGAGGCATTGAAAAAATACTGCTCCACCTGCGACATATCCTTCAACTATGTAAAGACATTTCTGGCGCACAAGCAATTCTACTGCAAGAGCAAACCACTCCGACCCGAGGCAAATGATAGCCCCAGTCCCACGGTGGGCGGTGGCGTCTCAATGCCGCTGCAGTCGCCCAgcgagctgctgttgctccagAAGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MGEKWARSTRIGGPHEKKTKQKKQKLFELIGAFISIAAMFYSKELAAHELSEEKQQQHQQHQQQQQQLEDQAEDEQLEQQSNNSSLQPVETDMEQELEEAQAAAQDSSEQKLEDNPTMTTPPRSPSPELVPKLERADTPPSVPVTPSPPPRTPTPPPIVLPKLRLNALLASDPALKPDAKELNLHDTRLLGPPPKPEQQPSLQPDVEPLLKPARFMCLPCSIAFSSPSTLEAHQAYYCSHRNKDAEEETNAAGDKVTSNSGGTSNANSSSSGSSATGSEPPNKVSRIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAAPSLNNLSSLTANGVVAAAAAAAAAAAAAAGAQLEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEAGGITGSGVGGAGAGGGGGAISVAAVAAGKHSPQTRNKTPTPAMVAAAAAAAAAASLQVAPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINTLGGSATPTPMPSSNQIPIPALEPDRPTPVNISSNLETEPKKSPPEPKRKEISGIRETTPLDLSLRRSPISALLQRQRLARSAAALLDAEDAAGKDAHLESISGGSVTPEQIVCAPSLPSSPSMSPSPKRRALSPRSSGAGSASSMSPPAHHLLDNLPPLRSMLPSDFNLSESLLAKTNPELALKLAAAAAAAVAGSGSAELAKLGFPGGSAATSSGATAPSSAQNAPQIYVKQGVSKCKDCNIVFCKYENYLAHKQHYCSARNQETGLDGDASKSAVTPPSGLSSVGGNAGASSAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCLKGGAAAAATPAEAAPAPQLPLAHPKEKCSKCKTHHEHGQNCPPPPPPATPQLPAPCSTSATSNSVNKCPVCGVISPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDAAAVAATVAAPTQSLNLDLPAVAAAAAAAAAAQEQLEQHPAQLFNCDHCNYASSYKGNVLRHMKLLHPHVAISSPSISPESREHEANPHALPEISLVNGEREAASMPSFHIKTEALEAPVATLSLVHENNNSPIGTPLTHIKAEPMELGVDVSVPSLPPPMANSPLGPSAAEALKKYCSTCDISFNYVKTFLAHKQFYCKSKPLRPEANDSPSPTVGGGVSMPLQSPSELLLLQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538480;
90% Identity: iTF_00570666;
80% Identity: -