Basic Information

Insect: Drosophila picticornis
Gene Symbol: ush
Assembly: GCA_035043845.1
Location: JAWNMR010000491.1:6488961-6494357[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.052 3.2 8.3 0.0 1 20 216 235 216 237 0.89

2 9 0.0003 0.019 15.3 0.8 1 23 292 314 292 314 0.98

3 9 0.054 3.3 8.2 1.0 2 21 364 383 364 384 0.92

4 9 0.037 2.3 8.7 3.0 2 21 767 786 766 787 0.93

5 9 0.0097 0.6 10.6 0.0 3 21 837 855 835 856 0.91

6 9 0.02 1.2 9.6 0.0 2 23 926 947 925 947 0.98

7 9 0.0041 0.25 11.8 1.3 1 23 953 975 953 975 0.99

8 9 0.0013 0.081 13.3 1.8 1 23 1040 1063 1040 1063 0.96

9 9 0.33 20 5.8 0.7 2 20 1173 1191 1172 1193 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.052	3.2	8.3	0.0	1	20	216	235	216	237	0.89
2	9	0.0003	0.019	15.3	0.8	1	23	292	314	292	314	0.98
3	9	0.054	3.3	8.2	1.0	2	21	364	383	364	384	0.92
4	9	0.037	2.3	8.7	3.0	2	21	767	786	766	787	0.93
5	9	0.0097	0.6	10.6	0.0	3	21	837	855	835	856	0.91
6	9	0.02	1.2	9.6	0.0	2	23	926	947	925	947	0.98
7	9	0.0041	0.25	11.8	1.3	1	23	953	975	953	975	0.99
8	9	0.0013	0.081	13.3	1.8	1	23	1040	1063	1040	1063	0.96
9	9	0.33	20	5.8	0.7	2	20	1173	1191	1172	1193	0.91

Sequence Information

Coding Sequence: ATGGGGGAGAAGTGGGCGCGGTCAACGCGCATTGGCGGCCCGCACGAGAAGAAGACGAAGCCGAAGAAGCAGAAACTCGTGGAGCTTATCGGCGCCTTCATATCTATCGCAGCCATGCTCTATTCCAAAGAATTGGCCGCACACGAGCTGAGCGAggagaagcaacagcaacaccagcagcaccaacaacaacaacagcaacagctcgaGGATCAGGCCGAAGACGAGCAGTTAGAGCAACAGTCGAACAACTCCTCCTTGCAACCCGTCGAGACTGATATGGAACAGGAACTGGAGGAGGCACAAGCGGCAGCCCAGGATTCCAGTGACCAGAAGTTGGCGGACAACCCGACCACGACAACGCCGCCGCGCAGCCCAACGCCCGAACTGGTGCCAAAGCTGGAGAGAGCTGATACGCCTCCCTCAGTTCCAGTCACGCCCAGTCCACCACCGCGCACGCCCACACCACCGCCAATTGTACTGCCCAAGTTGCGACTCAATGCGCTGCTTGCCTCAGATCCGGCATTGAAGCCTGATGCCAAGGAGCTCAATCTGCACGAGTCACGACTGCTGGGTCCACCGCCCAAGCCGGAGCAGCAGCCGACTCTGCAGCCGGATGTGGAGCCGCTGTTGAAACCGGCGCGATTTATGTGCCTGCCGTGCAGCATCGCTTTCAGTTCACCATCAACGCTGGAGGCGCATCAGGCCTACTACTGCTCCCATCGCAACAAGGATGCTGAGGAGGAGACAAACGCTGTCGGTGATAAGGTGACATCCAATAGCGGTGGCACCTCaaatgccaacagcagctccagcgGCTCAAGTGCCGCCGGCTCCGAGCCACCCAACAAGGTATCCCGCATTGGCAAGCAATATGCGTGCACCCAGTGCTCCTACAGTGCCGACAAGAAGGTCTCCCTCAATCGACACATGCGCATGCATCAAACATCTCCAGCGGCACCCAGCCTAAACAGCCTCTCCAGCTTGACAGCAAAtggtgttgttgccgctgctgctgccgccgctgcggcggctgctgctgctgctggtgcgcaGCTCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATCCGCTTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCAGCGACGGACAACTGACGCCCAAGCCGGAGGCGGGTGGCATCACTGGGACTGTAGTTGGAGTCGGtggagctggtgctggtggtggcggtggagccgcatcagttgctgctgttgctgccggcaAGCATAGTCCACAGACGCGCAACAAGACGCCAACGCCAGCaatggttgctgctgccgccgccgccgctgcggctgctgctgcctcgcTGCAGGTGGCACCACCGCAACCCTTCCTAGCGCTGCCCACCAATCCGATTATCATAGTGCCCTGCTCGCTAATACGTGCTGCCAGCTTGATACCGGGACCACTCACCACTTCTACGTCGGGCATTGTGAATCCGGAGTCCACATGCTTCACGCTCGACAATGGCGCTCTGAAGCCCCTTGCCACGGCTCTAAACATAAACACGCTAGGGGGCAGTGCCACGCCTACGCCTACGCCTATGCCAAGCAGCAATCAAATACCGATTCCCGCTTTAGAGCCAGATCGTCCAACTCCTGTGAGCATTTCGAGCAACCCGGAAACGGAACCCAAGAAAAGTCCAGCAGAACCCAAGCGCAAGGAAACAAGTGGCATACGTGAGACGACGCCCCTGGATTTATCGCTGAGGCGTTCGCCAATCTCAGCGCTGTTGCAGCGCCAGCGTCTCGCGCGCTCGGCCGCTGCACTGCTCGACGCCGAGGATGCTGCAGGCAAGGATGCTCACTTGGAGAGCATCAGTGGCGGCAGCGTTACACCCGAGCAAATTGTTTGCGCTCCCTCGCTGCCCAGCAGCCCCTCGATGAGTCCGTCACCCAAGCGACGTGCTTTAAGTCCACGCAGCTCTGGAGCTGGTAGCGCTTCGTCGATGTCACCGCCAGCCCACCATATGCTGGATAATTTGCCGCCGTTGCGCTCCATGCTGCCCTCCGATTTTAATCTATCCGAATCGCTGCTGGCCAAAACGAATCCAGAGCTGGCCCTCAAactggcggcggcagcagccgctgctgtgGCAGGCAGTGGCTCGGCGGAGCTGGCCAAACTAGGATTTTCGGGAGCTGGTGCAGCACCCAGCAGTGGTGCAGCTGCTCCATCCTCTGCACAGAATGCACCGCAGATCTATGTGAAGCAGGGCGTCTCCAAGTGCAAGGACTGCAACATTGTCTTCTGCAAATATGAGAATTACTTGGCGCACAAGCAACATTATTGCTCGGCACGCAACCAGGAGACGGGCCTGGATGGAGATGCCTCCAAAAGCGCTGTAACGCCTCCCAGTGGGTTATCATCAGTTGGTGGTAATGCTGGCGCCTCCTCTGCAGAAACGACCCCCGTTGCCTACCAGCAACTAATATGCGCCGCCTGCGGCATTAAATACACCTCGTTGGATAATTTGCGTGCGCATCAGAATTACTACTGCCTGAAAGGAGGCGCTGCGTCAGCAGCCACGCCAGCTgaggcagcaccagcaccacaacTGCCACTCGCCCATCCCAAGGAGAAGTGCCCGAAATGTAAGACTCATCATGAGCACGGACAGAATTGTCCACCACCCCCACCACCAGCAACTCCTCAACTGCCTGCTCCGTGCTCCACCTCTGCCACATCGAATAGTGTCAATAAGTGTCCCGTTTGTGGCGTAATTAGTCCCACTGCTGCTCTCGCCCGCAAGCACATGGAGATGCATGGAACAGTGAAGGCTTTTCGCTGCTCCATTTGCCAGTATAAAGGGAACACTCTCCGCGGGATGCGCACCCACATTCGCACCCATTTCGATAAGAAGACGAGCGATGTGAACGAGGAGCACTACATGACATGCATCTTTGAGGAGGATGCTGCAGCggtggcagctgcagttgctgctccaACTCAATCCTTGAATCTAGATCTGCCcgctgtggcagcagcggcggcggcagcagcagcagcccaagaGCAACTGGAACAGCATCCGGCACAGCTCTTCAATTGCGATCATTGCAATTACGCCTCATCCTACAAGGGCAATGTGCTGCGTCACATGAAATTATTGCATCCACATGTGGCCATTAGTTCGCCCTCCATTTCACCCGAGTCGCGCGAACACGAAGCCAATCCACACGTCCTACCCGAAGTAGCACTGCTTAATGGGGAACGGGAGGCAGCAGCTGTGCCCGGCTTCCACATTAAAACGGAGGCATTGGAGGCACCGGTGGCCACATTGAGTCTGGTTCATGAGAACAACAATTCACCCATTGGCACACCACTTACCCACATTAAAGCGGAGCCCATGGAACTTGGAGTAGATGTGTCAGTACCGTCGCTACCCCCGCCGATGGCCAATTCCCCGCTTGGGCCGAGCGCAGCGGAGGCATTGAAAAAATACTGCTCCACCTGCGACATATCGTTCAACTATGTGAAGACATTTCTGGCGCACAAGCAATTCTACTGCAAGAGCAAACCGCATCGACCCGAGGCAAATGATAGCCCCAGTCCCACGGTGGGTGGTGGCGTCTCAATGCCGCTGCAGTCGCCCAgcgagctgctgttgctccagaAGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MGEKWARSTRIGGPHEKKTKPKKQKLVELIGAFISIAAMLYSKELAAHELSEEKQQQHQQHQQQQQQQLEDQAEDEQLEQQSNNSSLQPVETDMEQELEEAQAAAQDSSDQKLADNPTTTTPPRSPTPELVPKLERADTPPSVPVTPSPPPRTPTPPPIVLPKLRLNALLASDPALKPDAKELNLHESRLLGPPPKPEQQPTLQPDVEPLLKPARFMCLPCSIAFSSPSTLEAHQAYYCSHRNKDAEEETNAVGDKVTSNSGGTSNANSSSSGSSAAGSEPPNKVSRIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAAPSLNSLSSLTANGVVAAAAAAAAAAAAAAGAQLEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEAGGITGTVVGVGGAGAGGGGGAASVAAVAAGKHSPQTRNKTPTPAMVAAAAAAAAAAAASLQVAPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINTLGGSATPTPTPMPSSNQIPIPALEPDRPTPVSISSNPETEPKKSPAEPKRKETSGIRETTPLDLSLRRSPISALLQRQRLARSAAALLDAEDAAGKDAHLESISGGSVTPEQIVCAPSLPSSPSMSPSPKRRALSPRSSGAGSASSMSPPAHHMLDNLPPLRSMLPSDFNLSESLLAKTNPELALKLAAAAAAAVAGSGSAELAKLGFSGAGAAPSSGAAAPSSAQNAPQIYVKQGVSKCKDCNIVFCKYENYLAHKQHYCSARNQETGLDGDASKSAVTPPSGLSSVGGNAGASSAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCLKGGAASAATPAEAAPAPQLPLAHPKEKCPKCKTHHEHGQNCPPPPPPATPQLPAPCSTSATSNSVNKCPVCGVISPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDAAAVAAAVAAPTQSLNLDLPAVAAAAAAAAAAQEQLEQHPAQLFNCDHCNYASSYKGNVLRHMKLLHPHVAISSPSISPESREHEANPHVLPEVALLNGEREAAAVPGFHIKTEALEAPVATLSLVHENNNSPIGTPLTHIKAEPMELGVDVSVPSLPPPMANSPLGPSAAEALKKYCSTCDISFNYVKTFLAHKQFYCKSKPHRPEANDSPSPTVGGGVSMPLQSPSELLLLQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538480;
90% Identity: iTF_00570666;
80% Identity: -