Basic Information

Insect: Drosophila cyrtoloma
Gene Symbol: ush
Assembly: GCA_035042485.1
Location: JAWNLH010000675.1:6726159-6731155[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.05 3.2 8.3 0.0 1 20 194 213 194 215 0.89

2 9 0.00029 0.019 15.3 0.8 1 23 270 292 270 292 0.98

3 9 0.051 3.4 8.3 1.0 2 21 342 361 342 362 0.92

4 9 0.035 2.3 8.8 3.0 2 21 745 764 744 765 0.93

5 9 0.0093 0.6 10.6 0.0 3 21 815 833 813 834 0.91

6 9 0.012 0.75 10.3 0.0 2 23 904 925 903 925 0.98

7 9 0.0039 0.25 11.8 1.3 1 23 931 953 931 953 0.99

8 9 0.0012 0.081 13.3 1.8 1 23 1018 1041 1018 1041 0.96

9 9 0.31 20 5.8 0.7 2 20 1151 1169 1150 1171 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.05	3.2	8.3	0.0	1	20	194	213	194	215	0.89
2	9	0.00029	0.019	15.3	0.8	1	23	270	292	270	292	0.98
3	9	0.051	3.4	8.3	1.0	2	21	342	361	342	362	0.92
4	9	0.035	2.3	8.8	3.0	2	21	745	764	744	765	0.93
5	9	0.0093	0.6	10.6	0.0	3	21	815	833	813	834	0.91
6	9	0.012	0.75	10.3	0.0	2	23	904	925	903	925	0.98
7	9	0.0039	0.25	11.8	1.3	1	23	931	953	931	953	0.99
8	9	0.0012	0.081	13.3	1.8	1	23	1018	1041	1018	1041	0.96
9	9	0.31	20	5.8	0.7	2	20	1151	1169	1150	1171	0.91

Sequence Information

Coding Sequence: ATGCGTTCGCGGGATAACCAAACGGCACAAACGGgccaaacagccaaacagccaaATGATTCCAAAGAATTGGCCGCACACGAGCTGAGCGAggagaagcaacagcaacaccagcagcaccaacaacaacagcaacagctcgAGGATCAGGCCGAAGACGAGCAGTTAGAGCAACAGTCGAACAACTCCTCCTTGCAACCCGTCGAGACTGACATGGAACAGGAACTGGAGGAGGCACAAGCGGCAGCCCAGGATTCCAGCGACCAGAAGTTGGCGGACAACCCGACCACGACAACGCCGCCGCGTAGCCCAACGCCTGGACTGGTCCCAAAGCTGGAGAGAGCTGATACGCCTCCCTCAGTTCCAGTCACGCCCAGTCCACCACCGCGCACGCCCACACCACCGCCAATTGTACTGCCCAAGCTGCGACTCAATGCGTTGCTTGCCTCAGATCCGGCATTGAAGCCCGATGCCAAGGAGCTCAATCTGCACGAGTCACGACTGCTGGGTCCACCGCCCAAGCCGGAGCAGCAGCCGACTCTGCAGCCGGATGTGGAGCCGCTGTTGAAACCGGCGCGATTTATGTGCCTGCCCTGCAGCATCGCTTTCAGTTCACCATCAACGCTGGAGGCGCACCAGGCCTATTACTGCTCCCATCGCAACAAGGATGCTGAGGAGGAGACAAACGCTGCCGGTGATAAGGTGACATCCAACAGCGGTGGCACCTCCAATGCCAACAGCAGCTCCAGCGGCTCAAGTGCCGCCGGCTCCGAGCCACCCAACAAGGTGTCCCGCATTGGCAAGCAATATGCGTGCACCCAGTGCTCCTACAGTGCCGACAAGAAGGTCTCCCTCAATCGACACATGCGCATGCATCAAACATCCCCAGCGGCACCCAGCCTAAACAGCCTCTCCAGCTTGACAGCAAATggtgttgttgccgctgctgctgccgccgctgcggcggctgctgctgctgctggtgcgcAGCTCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATCCGCTTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCAGCGACGGACAACTCACGCCCAAGCCGGAGGCGGGTGGCATCACTGGGACTGTAGTTGGAGTTGGTGgagctggtgctggtggtggaggtggagctgcatcagttgctgctgttgctgccggcaAGCATAGTCCACAGACGCGCAACAAGACGCCGACGCCAGCaatggttgctgctgccgccgccgcagctgcggctgctgctgcctcgctGCAGGTGGCACCACCGCAACCCTTCCTAGCGCTGCCCACCAATCCGATTATCATAGTGCCCTGCTCGCTAATACGTGCTGCCAGCTTGATACCGGGACCACTCACCACTTCTACGTCGGGCATTGTGAATCCGGAGTCCACATGCTTCACGCTCGACAATGGCGCTCTGAAGCCGCTAGCCACGGCTCTGAACATAAATACGCTAGGGggcagtgccacgcccacgcctaCGCCTATGCCCAGCAGCAATCAGATACCGATTCCCGCTTTAGAGCCAGATCGTCCAACTCCTGTGAGCATTTCGAGCAACCTGGAAACGGAACCCAAGAAAAGTCCAGCAGAACCCAAGCGCAAGGAAACAAGCGGCATACGTGAGACGACGCCACTGGATTTATCGCTGAGACGCTCGCCAATCTCAGCGCTGTTGCAGCGCCAGCGCCTCGCGCGCTCTGCCGCAGCATTGCTCGACGCCGAGGATGCTGCAGGCAAGGATGCTCACTTGGAGAGCATCAGTGGCGGCAGCGTTACACCCGAGCAAATTGTTTGCGCTCCCTCGCTGCCCAGCAGCCCCTCGATGAGTCCCTCACCCAAGCGACGTGCTTTAAGTCCACGCAGCTCTGGAGCTGGCAGCGCTTCGTCGATGTCACCGCCAGCCCACCATATGCTGGATAATTTGCCGCCGTTGCGCTCTATGCTGCCCTCCGACTTTAATCTCTCCGAATCGCTGCTGGCTAAAACGAATCCAGAGCTGGCCCTCAAactggcggcggcagcagcggctgctgtgGCAGGCAGTGGCTCGGCGGAGCTGGCCAAACTAGGATTTGCAGGAACTGGTGGAGCACCCAGCAGTGGTGCTGCTGCACCATCCTCTACACAGAATGCACCGCAGATCTATGTGAAGCAGGGCGTCTCCAAGTGCAAGGACTGCAATATTGTCTTCTGCAAATATGAGAATTACTTGGCGCACAAGCAACATTATTGCTCGGCACGCAACCAGGAGACGGGCCTGGACGGAGATGCCTCCAAAAGCGCTGCAACGCCTCCCAGTGGACTATCATCAGTTGGCGGTAATGCTGGCGCCTCCTCTGCAGAAACCACTCCCGTTGCCTATCAGCAACTAATATGCGCCGCCTGCGGCATTAAATACACCTCGCTGGATAATTTGCGTGCGCATCAGAATTACTACTGTCTGAAAGGAGGCGCTGCGGCAGCTGCCACGCCAGCTgaggcagcaccagcaccacaacTGCCACCCGCACATCCCAAGGAGAAGTGCCCGAAATGCAAAACTCATCATGAGCACGGACAGAATTGTCCCGCACCCCCACCACCAGCAACTCCACAACTGCCTGCTCCCTGCTCCACCTCTGCCACGTCGAATAGTGTCAATAAGTGTCCCGTTTGTGGCATAATTAGTCCCACTGCTGCTCTCGCCCGCAAGCACATGGAGATGCATGGAACGGTGAAGGCTTTTCGCTGCTCCATTTGCCAGTATAAAGGGAACACTCTCCGCGGGATGCGCACCCACATTCGCACCCATTTCGATAAGAAGACCAGCGATGTGAACGAGGAGCACTACATGACATGCATCTTTGAGGAGGATGCTGCAGCggtggcagctgcagttgctgctccaACTCAATCCTTGAATCTAGATCTGCCCGCcgtggcagcagcggcggcggcagcagcagcagcccaagaGCAACTGGAACAGCATCCGGCACAGCTCTTCAATTGCGATCATTGCAATTATGCCTCATCCTACAAGGGCAACGTGCTGCGTCACATGAAATTACTGCATCCACATGTGGCCATTAGTTCGCCCTCCATTTCACCCGAGTCGCGCGAACACGAAGCCAATCCACACGCCCTACCCGAAGTAGCGCTGGTTAATGGGGAACGGGAGGCAGCAGCTGTGCCCAGCTTCCACATTAAAACGGAGGCATTGGAGGCACCGGTGGCCACATTGAGTCTGGTGCATGAGAACAACAATTCACCCATTGGCACACCACTTACCCACATTAAAGCGGAGCCCATGGAACTTGGAGTAGATGTATCAGTACCGTCGCTACCCCCGCCGATGGCCCATTCCCCGCTTGGGCCGAGCGCAGCGGAGGCATTGAAAAAATACTGCTCCACCTGCGACATATCCTTCAACTATGTGAAGACATTTCTGGCGCACAAGCAATTCTACTGCAAGAGCAAACCGCTTCGACCCGAGGCAAATGATAGCCCCAGTCCCACGGTGGGTGGTGGCGTCTCAATGCCGCTGCAGTCGCCCAgcgagctgctgttgctccagAAGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MRSRDNQTAQTGQTAKQPNDSKELAAHELSEEKQQQHQQHQQQQQQLEDQAEDEQLEQQSNNSSLQPVETDMEQELEEAQAAAQDSSDQKLADNPTTTTPPRSPTPGLVPKLERADTPPSVPVTPSPPPRTPTPPPIVLPKLRLNALLASDPALKPDAKELNLHESRLLGPPPKPEQQPTLQPDVEPLLKPARFMCLPCSIAFSSPSTLEAHQAYYCSHRNKDAEEETNAAGDKVTSNSGGTSNANSSSSGSSAAGSEPPNKVSRIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAAPSLNSLSSLTANGVVAAAAAAAAAAAAAAGAQLEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEAGGITGTVVGVGGAGAGGGGGAASVAAVAAGKHSPQTRNKTPTPAMVAAAAAAAAAAAASLQVAPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINTLGGSATPTPTPMPSSNQIPIPALEPDRPTPVSISSNLETEPKKSPAEPKRKETSGIRETTPLDLSLRRSPISALLQRQRLARSAAALLDAEDAAGKDAHLESISGGSVTPEQIVCAPSLPSSPSMSPSPKRRALSPRSSGAGSASSMSPPAHHMLDNLPPLRSMLPSDFNLSESLLAKTNPELALKLAAAAAAAVAGSGSAELAKLGFAGTGGAPSSGAAAPSSTQNAPQIYVKQGVSKCKDCNIVFCKYENYLAHKQHYCSARNQETGLDGDASKSAATPPSGLSSVGGNAGASSAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCLKGGAAAAATPAEAAPAPQLPPAHPKEKCPKCKTHHEHGQNCPAPPPPATPQLPAPCSTSATSNSVNKCPVCGIISPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDAAAVAAAVAAPTQSLNLDLPAVAAAAAAAAAAQEQLEQHPAQLFNCDHCNYASSYKGNVLRHMKLLHPHVAISSPSISPESREHEANPHALPEVALVNGEREAAAVPSFHIKTEALEAPVATLSLVHENNNSPIGTPLTHIKAEPMELGVDVSVPSLPPPMAHSPLGPSAAEALKKYCSTCDISFNYVKTFLAHKQFYCKSKPLRPEANDSPSPTVGGGVSMPLQSPSELLLLQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538480;
90% Identity: iTF_00570666;
80% Identity: -