Dcra004173.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila cracens
Gene Symbol
zfh1
Assembly
GCA_035042505.1
Location
JAWNLF010000356.1:19384-43221[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.007 0.47 11.0 1.5 2 23 61 83 60 83 0.95
2 9 0.004 0.27 11.8 1.4 1 23 278 300 278 300 0.97
3 9 2.6e-05 0.0018 18.6 2.7 2 23 315 336 314 336 0.97
4 9 3.9e-05 0.0026 18.1 6.4 1 23 345 367 345 367 0.99
5 9 5.1e-05 0.0034 17.7 1.6 1 21 373 393 373 394 0.95
6 9 0.03 2 9.0 0.4 2 21 682 701 681 702 0.92
7 9 1.5e-05 0.001 19.4 0.5 1 23 1043 1065 1043 1065 0.94
8 9 5.6e-05 0.0038 17.6 7.4 1 23 1071 1093 1071 1093 0.98
9 9 0.0028 0.19 12.3 4.3 1 21 1099 1119 1099 1120 0.96

Sequence Information

Coding Sequence
ATGAGCATGAGAAATGCTTCCCAGCAAGCAGCAGTTCCCTCTTTGGCGTCCAGTTTACACCATCACCAAAccaccacacacaacaacagccaggCAAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGCCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGCCTGGTCAAATGCCCCCAATGCCACAAGCGCTTCAATGAGTTTCAGTCATTTAGCGAACACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCCGAAAGCGAGCCCGAGGCGGAGCAGGAGGATGACGAGgaagaggatgaggaggaggagcacaGCAAtctaagcagcagcagccaacaacgcTATGCCAAATccccaagcaacaacaacaataacaacaacaacagcagtcacaacaacaacaacaataataacagtgAAACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGCTCCCCCGTTGCCCCCGCCACGCCCGGCGATCTGTTCGCCCATCTGCCACACCCTGCCgcccatttgcaatttgtggcagccGCCGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCACCCAACAACCAACaccaacagttgcaacaacagcagcaacagcagcagcagcaacagcaacagttgcagcagaagccgagcagcaacagcagcagcattggcagcaATTCCGCCTATGATCTGGATTTGAGTGCCCATCGATCCACCTCCAGTCCGGGCTCCACGGCTGGTGGAGATCTCCCAGCTGCCGGCTTCCCCTGCATGCAGTGCACGGCCACCTTCCACAGTCGCGAGCAGCTCGAGCAACATCAGCTGCTGCACTCGCCGACGCGGcaacacacaatcacacagaATGTCAAACAGACCTGCAAAATCTGTCACAAAACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCCGCGCTGCTGCGTAAATTCAAGTGTAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCATCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTGAAACTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCGGAGCAACTGCCTCCGGTGAAGCGCTCGGCCTGCAAACAGTTGGTGGAACCGGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGGGATTCACAAACATCACctgttggagttggagttactggtggtgctgcagctgctgctcctcctcctcctcccttTTATTCCAACTATAGTGCAATGAATGCGGCTTTGTTGGCATTTCCCAATGCTTTTATGGCGGCTGCTCTAGATCCACGCATGCATCCTTATAGCATACAGAGATTGCTGGAGCTAACAGCGGcaggacaacagcagcaccagcagcagcagcagcagagggagcaggaggagcagcacagagagcagcaggagctgaagagggagcaggagcaggaatTGGAAagggagcaggagcaggagagggagcagcagttgcaaagagaacaggagcagcagcagcgggagagggagagggagcaGGCGCATCGGGAGCAGTTGCAATTGGTGCCCAGCAAACAGGAGGATTACGCAGATGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCATCTAAAtagagcagctgcagcagcagctgcagaaacCAGGGCAGCTGTCAAAATGGAGATCAGTCGCGAGACAACGCCACATCCCGCAGAAGCAGTCAAAGCCATCAAGCAGGAGCgggaacaggagcaggaacaggagGAGCAAATGGAGCTGGACATGCAGATGGATCtggagaaggagcagcagcagcaatcctCCCCGGTGACAATGCCCCAATCAAGCCCCGAACTGCGCTGCAGTCGCTGTGCCAAGCAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacactatcaacaacagcaacaacagcagctccagcagcagcagcaactccagcaAACTCCGCGCTCCCTTTCCGAtttcgacgacgacgaggatgtGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGTAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTACGCACACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTGGATGCGAGGGTTGTCCAGGTGTGGTTTCAAAACAATCGCTCGAGGGAGCGCAAGCTGCAAAGCTACACAAGTGCCGGGGCTGGCAACACTGAGACGGCCACGGCAATCCTGGCCAGCTCTGCTGCACTGCCTCCCGCACGTGGCGAGGATCAACCTTTGGATTTATCCCTGAAGCGGGATGCAACGCCGCCTCagtcgcagctgcagctgccaccggATTACAGTGAGGCCAGCATGGCCATCAACCTGAGTCGCCGTCAGTTGTCCAACCCGGCTGCGTCTGCCATGTCGCCTGCTTCGCtcgcggcggcggcggcggcaactcTTTACTTTGCCCCACCCTCACCGACGGCGGGCCCCTTGCACAGCGCCACGCCCCCTTTGGCAGCACAGCGAGGCACCCCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGGGAATATGCGCCCAATCCTCTGATGAACAGTATTAAATTGCCGGACTATCATCGCGGCACCAGCCTCAGTCCGGGTGGCTCCGAGAAGCGTTCGTGGCGCGACGATGACTCGCGCATCTCCCACGAGGATGACTATGTCCTGGCCACGGGCGGTCTGCTGGCGCCCAAGCCGAGGCGCGCCAAGGCCGAGACTCATGGACATGCCGGCGATCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGACTGCCCGAAGGCGTTCAAGCACAAGCACCATTTGACGGAGCACAAGCGATTGCATTCCGGTGAGAAGCCGTTCCAGTGTTCCAAGTGCCTGAAGCGCTTCTCGCACTCGGGCAGCTACAGTCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence
MSMRNASQQAAVPSLASSLHHHQTTTHNNSQASNVAAASTEHVPHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPESEPEAEQEDDEEEDEEEEHSNLSSSSQQRYAKSPSNNNNNNNNSSHNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPGDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQHQQLQQQQQQQQQQQQQLQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTITQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQTSPVGVGVTGGAAAAAPPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQHQQQQQQREQEEQHREQQELKREQEQELEREQEQEREQQLQREQEQQQREREREQAHREQLQLVPSKQEDYADEPKLVMDLEQDAEHLNRAAAAAAAETRAAVKMEISRETTPHPAEAVKAIKQEREQEQEQEEQMELDMQMDLEKEQQQQSSPVTMPQSSPELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQHYQQQQQQQLQQQQQLQQTPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTSAGAGNTETATAILASSAALPPARGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSNPAASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLAAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE