Dpla012510.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila planitibia
Gene Symbol
zfh1
Assembly
GCA_035043785.1
Location
JAWNMS010000086.1:3805126-3827611[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.007 0.44 11.0 1.5 2 23 54 76 53 76 0.95
2 9 0.0041 0.25 11.7 1.4 1 23 286 308 286 308 0.97
3 9 2.7e-05 0.0016 18.6 2.7 2 23 323 344 322 344 0.97
4 9 4e-05 0.0024 18.1 6.4 1 23 353 375 353 375 0.99
5 9 5.1e-05 0.0032 17.7 1.6 1 21 381 401 381 402 0.95
6 9 0.03 1.9 9.0 0.4 2 21 694 713 693 714 0.92
7 9 1.5e-05 0.00093 19.4 0.5 1 23 1055 1077 1055 1077 0.94
8 9 5.6e-05 0.0035 17.6 7.4 1 23 1083 1105 1083 1105 0.98
9 9 0.0028 0.17 12.2 4.3 1 21 1111 1131 1111 1132 0.96

Sequence Information

Coding Sequence
ATGATCACTAAAGTTCCCTCTTTGGCGTCCAGTTTACACCATCACCaaagcacaacacacagcaacagccaggCGAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCCCCAGTGCCACAAGCGCTTCAACGAGTTTCAGTCCTTTAGCGAGCACATTGCCAGCGAGCATCCGCTGGACAAGTTAAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCCGACAGCGAGCCCGAGGCGGAgcccgaggaggaggaggaggacgaggaggaggagcacaGCAatctgagcagcagcagcaatcctCACTATGCCAAATccccaagcaacaacaacaataacaacaacaacagtcacaacaataacaacaaccacaacaaccataataataataataataataatagtgaaACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGTTCCCCCGTCGCCCCCGCCACGCCCAGTGATCTGTTCGCCCATCTGCCGCATCCTGCCgcccatttgcaatttgtggcagCCGCTGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCAcccaacaaccaacagcagcagttgcaacaacaacagcaacagcagcaacagttgcagcaacaccagcagcaacagcagcagcagcaacatcaacagaagccgagcagcaacagcagcagcatcggcaGCAATTCCGCCTACGATCTGGATCTGAGTGCACATCGTTCCACCTCCAGTCCGGGCTCCACGGCTGGCGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACAGCCACCTTCCACAGTCGCGAGCAGCTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAACGTCAAACAGACCTGCAAGATCTGCCACAAGACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCGGCGCTGCTGCGCAAATTCAAGTGCAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAGCTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCCGAGCAGCTGCCTCCGGTGAAGCGTTCGGCCTGCAAACAGTTGGTGGACCCAGTTCTCCCAAATCTGCCCATGAACTATTTCGCTGGCGATTCACAGTCATCgccagttggagttggagttggagttgctggtgccgctgcagctgctgctgctgctccgcctCCTCCCTTTTATTCCAATTATAGTGCAATGAATGCGGCCCTGCTGGCGTTTCCCAATGCTTTCATGGCGGCTGCTTTGGATCCGCGCATGCATCCCTACAGCATACAGAGATTGCTGGAGCTGACAGCGgcaggacagcagcagcagcagcagagggagcaggaggagcagcacagagagcagcaggagctgaaGAGGGAGCAGGAGCGGGAGCAGGAGTTGGAAagggagcaggagcaggagcaggagcgggagcagcagctgcaaagagagcagcagcagcaggagcagttCGAGCAGGAGCGGAAGCGGGAGCAGGCGCAGCgggagcagctgcaattgctgcccAGCAAACAGGATGATTATGCAGAGGAGCCCAAGCTGGTCATGGATCTGGAGCAGGATGCAGAGCACCCAAatagcgcagcagcagccgcagcagcaggagcagaaacGAGAACAGCTGTCAAAATGGAGATGAGTCGCGAGACAACCCCACAGCCCGTGGAAGCACTCGCAGCCATCAAGCAGGAGcgggaacaggagcaggaggagcaaATGGAGCTGGACATGCAGATGGATCTGGAgaaggaacagcagcagcagcagcaatcctCCCCCCAGCCAAGCCAGGAACTGCGCTGCAGTCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcagcagcagcactatcaacaacagcagcagcagcagcagcagcagctgcagcagcagcagcaagctcCTCGCTCCCTTTCCGACTTCGATGACGACGAGGATGTGGAGGAGCTGCTGGAGGAGCCGCGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTCCGCACCGCCATCaacgaggagcagcagcagcagctgaagcagcacTATGCCCACAATCCACGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCACCTCCAGCTGGATGCGCGGGTTGTCCAGGTCTGGTTCCAGAACAATCGCTCACGGGAACGCAAGCTGCAGAGCTATACGGGTGGCGGGGCTGGCAGCGCTGAGCCAGCAGTGCTGGCCAGCTCTGCTGCACTGCCGCCGACACGTGGCGAGGATCAGCCGCTGGACTTGTCGCTGAAGCGGGACGCAACGCCGCCCCagtcgcagctgcagctgccacccGATTACAGTGAGGCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCGGCTCGACGGCGTCTGCCATGTCGCCGGCTTCCCtcgcggcggcggcggcggccaCGCTCTACTTTGCCCCGCCCTCGCCGACGGCGGGCCCCTTGCACAGTGCCACGCCCCCGTTGGGGGCACAGCGTGGCACACCCTTCGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCGATGGAGGCGCTCTTCCAGATGCGCCCGGGCGGTGAATACGCACCCAATCCGCTGATGAACAGTATTAAATTGCCGGACTATCATCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCCCACGAGGACGACTACGTCCTGGCCACGGGCGGCCTGCTGGCGCCGAAGCCGCGGCGCGCCAAGGCCGAGACCCATGGCCATGCCGGCGACCCCGATCTGCCCTTCGTGTGTGATCAGTGCGACAAGGCGTTTGCCAAGCAGAGCTCCTTGGCCCGGCACAAATACGAGCATTCCGGTCAGCGACCGTACCAGTGCATGGACTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGACTGCATTCCGGCGAGAAGCCGTTCCAGTGCTCCAAGTGCCTGAAACGGTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence
MITKVPSLASSLHHHQSTTHSNSQASNVAAASTEHVAHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEAEPEEEEEDEEEEHSNLSSSSNPHYAKSPSNNNNNNNNSHNNNNNHNNHNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQQQQLQQQQQQQQQLQQHQQQQQQQQHQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVDPVLPNLPMNYFAGDSQSSPVGVGVGVAGAAAAAAAAPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQREQEEQHREQQELKREQEREQELEREQEQEQEREQQLQREQQQQEQFEQERKREQAQREQLQLLPSKQDDYAEEPKLVMDLEQDAEHPNSAAAAAAAGAETRTAVKMEMSRETTPQPVEALAAIKQEREQEQEEQMELDMQMDLEKEQQQQQQSSPQPSQELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQQQQQQQQQLQQQQQAPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGGGAGSAEPAVLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSGSTASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLGAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE