Basic Information

Insect: Drosophila ochracea
Gene Symbol: zfh1
Assembly: GCA_035044125.1
Location: JAWNML010000062.1:1381528-1417375[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.045 2.8 8.5 4.1 2 23 83 105 82 105 0.95

2 9 0.0042 0.27 11.7 1.4 1 23 304 326 304 326 0.97

3 9 2.8e-05 0.0017 18.6 2.7 2 23 341 362 340 362 0.97

4 9 4.1e-05 0.0026 18.0 6.4 1 23 371 393 371 393 0.99

5 9 5.3e-05 0.0034 17.7 1.6 1 21 399 419 399 420 0.95

6 9 0.032 2 8.9 0.4 2 21 725 744 724 745 0.92

7 9 1.6e-05 0.00099 19.3 0.5 1 23 1088 1110 1088 1110 0.94

8 9 5.9e-05 0.0037 17.5 7.4 1 23 1116 1138 1116 1138 0.98

9 9 0.0029 0.18 12.2 4.3 1 21 1144 1164 1144 1165 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.045	2.8	8.5	4.1	2	23	83	105	82	105	0.95
2	9	0.0042	0.27	11.7	1.4	1	23	304	326	304	326	0.97
3	9	2.8e-05	0.0017	18.6	2.7	2	23	341	362	340	362	0.97
4	9	4.1e-05	0.0026	18.0	6.4	1	23	371	393	371	393	0.99
5	9	5.3e-05	0.0034	17.7	1.6	1	21	399	419	399	420	0.95
6	9	0.032	2	8.9	0.4	2	21	725	744	724	745	0.92
7	9	1.6e-05	0.00099	19.3	0.5	1	23	1088	1110	1088	1110	0.94
8	9	5.9e-05	0.0037	17.5	7.4	1	23	1116	1138	1116	1138	0.98
9	9	0.0029	0.18	12.2	4.3	1	21	1144	1164	1144	1165	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTGTTTTGGCCAAGAGGATAACATAATAATACAGCAGAGCATGCCATCTTCTACAGCCTTCTCCATGCAGTTTCCCTCTTTGGCGTCCAGTTTACACCATCACCAaaccacaacacacaacagccAGGCGAGCAATGTGGCCGCTGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCACCAATGCCACAAGCGCTTCAACGAGTTTCAGTCCTTTAGCGAGCACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAACAGCCGCATCCAGGCGCAGCTCAGCCCGACAGCGAGCCCGAGGCGGAGCccgaggaagaggaggaggatgaggaggaggagcacaGCAAtctaagcagcagcagcaatcctCGTTATGCCAAATccccaagcaacaacaataacaacaacaacaacagtcacaataacaacatcaacaataataataataataataacaatagtgAAACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGTTCCCCCGTTGCCCCCGCCACGCCCAGTGATCTGTTCGCCCATCTGCCGCATCCTGCCgcccatttgcaatttgtggcagcCGCTGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCACccaacaaccagcagcaacagttgcaacaacaacaacatcaacaacagcagcaacaacagcagcagcaacagaagccgagcagcaacagcagcagcatcggcagCAATTCCGCCTACGATCTGGATTTGAGTGCCCATCGTTCCACCTCCAGTCCGGGCTCGACGGCTGGCGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACGGCCACCTTCCACAGTCGCGAGCAACTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAATGTCAAACAGACTTGCAAGATCTGCCACAAGACATTCGCGAATGTGTATCGCCTGCAGCGACACATGATTAGCCACGATGAGTCCGCGCTGCTGCGCAAGTTCAAGTGCAATCAATGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAACTCAATAACAATCGCCAGCTGCTCAAACCGCTGGACAAGAATGCCGAGCAACTGCCTCCGGTGAAGCGTTCGGCCTGCAAACAGTTGGTGGAGCCAGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGAGATTCACAGTCATCAccagtcggagtcggagtcggagttggagttggagttgctgGTGgtcctgcagctgcagctgttcctcctcctcctcctcactTTTATTCCAATTATAGCGCAATGAATGCGGCTCTGTTGGCATTTCCCAATGCTTTTATGGCGGCTGCTTTGGATCCACGCATGAATCCCTACGGCATACAGAGATTGCTGGAGCTAACAGCGGcaggacaacagcagcagcagcagagggagcaggaggagcagcacagagagcagcaggagctgaaGAGGGAGCAggagcgggagcgggagcAGGAGTTGGAAagggagcaggagcaggagcaggaaagggagcagcagctgcaaagagagcacgagcagcagcagcagcaggcgcagtTCGAGCAGGAGCGGAAGCGGgagcagttgcaattgctgcccAGCAAACAGGATGATTATGCAGAGGAGCCCAAGCTGGTCATGGATCTGGAGCAGGATGCAGAGCACCTAAacatcgcagcagcagcagcagcagcaacagcagcagaagcgagGACAGCTGTCAAAATGGAGATGAGTCGCGAGACAACGCCACAGCCCGTCGCAGCACTCACAGCCATCAAGCAGGAGcgggaacaggaacaggagcaggaggagcaaATGGAGCTGGACATGCAGATGGATCTGGAGAAGGAAcagcaggaacaggagcagcagcagcagcagcaaccctcCCCCCAGTCAAGCACGGAGCTGCGCTGCAGTCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacagcaacactatcaacaacagcaacaacagcaacagcagcagcaactgcagcagcagcagcagcaaactcCTCGCTCCGTTTCCGACttcgatgacgatgaggatgtGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTCCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTATGCCCACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTGGATGCGAGGGTTGTCCAGGTGTGGTTCCAAAACAATCGCTCGCGAGAACGCAAGCTGCAGAGCTATACAGGTGGCGGGGCTGGCAACACTGAGACAGCATTGCTTGCCAGCTCTGCTGCACTGCCTCCGACACGTGGCGAGGATCAGCCGCTGGATTTGTCGCTGAAGCGGGATGCAACGCCGCCCCAgtcgcagctgcagttgccacCGGATTACAGCGAGGCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCAGCTCGACGGCTTCTGCCATGTCGCCGGCTTCTCtcgcggcggcggcggcggccaCTCTCTACTTTGCCCCACCCTCACCGACGCCGGGCCCCTTGCAcagtgccacgcccccttTGGGGGCACAGCGTGGCGCACCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGTGAATATGCACCCAATCCACTGATGAACAGTATTAAATTGCCGGATTACCATCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCCCACGAGGACGACTATGTCCTGGCCACGGGTGGTCTGCTGGCGCCGAAGCCGCGGCGTGCCAAGGCCGAGACTCATGGCCATGCCGGGGACCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGTTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGATTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGATTGCATTCCGGCGAGAAGCCGTTTCAGTGTTCCAAGTGCCTGAAGCGGTTCTCGCACTCGGGGAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRCFGQEDNIIIQQSMPSSTAFSMQFPSLASSLHHHQTTTHNSQASNVAAASTEHVAHATSAATANAADECLVKCHQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEAEPEEEEEDEEEEHSNLSSSSNPRYAKSPSNNNNNNNNSHNNNINNNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQQQQLQQQQHQQQQQQQQQQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKPLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQSSPVGVGVGVGVGVAGGPAAAAVPPPPPHFYSNYSAMNAALLAFPNAFMAAALDPRMNPYGIQRLLELTAAGQQQQQQREQEEQHREQQELKREQEREREQELEREQEQEQEREQQLQREHEQQQQQAQFEQERKREQLQLLPSKQDDYAEEPKLVMDLEQDAEHLNIAAAAAAATAAEARTAVKMEMSRETTPQPVAALTAIKQEREQEQEQEEQMELDMQMDLEKEQQEQEQQQQQQPSPQSSTELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQQQQQQQQQQLQQQQQQTPRSVSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGGGAGNTETALLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSSSTASAMSPASLAAAAAATLYFAPPSPTPGPLHSATPPLGAQRGAPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00564549;