Basic Information

Insect: Drosophila demipolita
Gene Symbol: zfh1
Assembly: GCA_035042405.1
Location: JAWNLI010000247.1:61710-93404[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.011 0.75 10.3 0.8 3 23 85 106 83 106 0.94

2 9 0.0029 0.2 12.1 1.4 1 23 301 323 301 323 0.97

3 9 2.5e-05 0.0018 18.6 2.7 2 23 338 359 337 359 0.97

4 9 3.7e-05 0.0026 18.1 6.4 1 23 368 390 368 390 0.99

5 9 4.8e-05 0.0034 17.7 1.6 1 21 396 416 396 417 0.95

6 9 0.029 2 9.0 0.4 2 21 707 726 706 727 0.92

7 9 1.4e-05 0.001 19.4 0.5 1 23 1073 1095 1073 1095 0.94

8 9 0.00026 0.018 15.4 8.7 1 23 1101 1123 1101 1123 0.98

9 9 0.0027 0.19 12.2 4.3 1 21 1129 1149 1129 1150 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.011	0.75	10.3	0.8	3	23	85	106	83	106	0.94
2	9	0.0029	0.2	12.1	1.4	1	23	301	323	301	323	0.97
3	9	2.5e-05	0.0018	18.6	2.7	2	23	338	359	337	359	0.97
4	9	3.7e-05	0.0026	18.1	6.4	1	23	368	390	368	390	0.99
5	9	4.8e-05	0.0034	17.7	1.6	1	21	396	416	396	417	0.95
6	9	0.029	2	9.0	0.4	2	21	707	726	706	727	0.92
7	9	1.4e-05	0.001	19.4	0.5	1	23	1073	1095	1073	1095	0.94
8	9	0.00026	0.018	15.4	8.7	1	23	1101	1123	1101	1123	0.98
9	9	0.0027	0.19	12.2	4.3	1	21	1129	1149	1129	1150	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTGTTTTGGCCAAGAGGATAACATAATAATACAGCAGAGTATGCCATCTTCCACAGCCTTCTCCATGCAGTTTCCCTCTTTGGCGTCCAGTTTACACCATCATCAaaccacaacacacaacaacagccagcCAAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGCCACATGCAACCAGTGCTGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCATATGCCCCCAGTGCCACAAGCGCTTCAATGAGTTTCAGTCGTTTAGCGAGCACATCGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCGGAGAGTGAGcccgaggaggaggatgaggaggaggagcacaGCAatctgagcagcagcagcaatcctCGCTATGCCAAATCcccaagcaacaataacaacaataacaacaacaataacaacaacagtcacaacaacaataacaataataataatagtgaaACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCCGCCTCGCTGGGCTCCCCCGTTGCCCCCGCCACGCCCAGCGATCTGTTTGCCCATCTGCCACACCCTGCCGcccatttgcaatttgtggcagCCGCCGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCACCCagcaaccaacagcaacagttgcaacaacaacaacaacagcaacaccagcagcagcagcagcagcaacagttgctacAGAAgccgagcagcaacagcagcagcattggcagCAATTCCGCCTATGATCTGGATCTGAGCGCCCATCGCTCCACCTCGAGTCCCGGCTCCACAGCTGGCGGAGATCTGCCAGCTGCCGGCTTCCCCTGCATGCAGTGCACAGCCACCTTCCACAATCGCGAGCAACTCGAGCAACATCAGCTGCTCCACTCGCCGACGAGGCAACACACAATCGCACAAAATGTCAAACAGACCTGCAAAATCTGTCACAAGACTTTCGCGAATGTGTATCGCCTGCAACGACACATGATTAGCCACGATGAGTCCGCGCTGCTACGCAAATTCAAGTGCAACCAGTGCGAGAAGGCGTTCAAATTCAAGCACCACCTGAAGGAGCACGTGCGCATCCACTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGATTCTCCCACTCGGGCAGCTTCTCTTCGCACATGACATCCAAGAAGTGCATCAGCATGTGCCTCAAGCTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCGGAGCAACTGCCTCCGACTAAGCGTTCGGCCTGCAAACAACTGGTGGAACCGGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGTGATTCACAAACATCTCcggttggagttggagttgctggcggtgctgcagctgctgttcctCCTCCGCCTCCCTTTTATTCCAATTATAGCGCAATGAATGCGGCTTTGTTGGCCTTTCCCAATGCTTTCATGGCGGCTGCCTTAGATCCACGCATGCATCCCTATAGCATACAGAGATTGCTGGAGCTAACAGCGGcaggacaacagcagcaccaacagcagcaacagcagcagagggaggaggaggagcagcacagagagcagcaggagctgaagagggagcaggagcaggagttAGAAAgggaacaggagcaggagagGGAAagggagcagcagctgcagagagagcagcaggagcagcagcggaCGAGGGAGCAGGCGCAGCGCGagcagttgcaattgctgccTAGCAAACAGGAGGAGTATGCAGAGGAGCCCAAACTGGTCATGGATCTGGAACAGGATGCAGAGCAcccagtagcagcagcaacagtggaaGCCAAGACAGCTGTCAAAATGGAGATCTGTCGCGAGACAACGCCACAGCCCACAGAAGCACTCAAAGCTATCAAGCAGGAACgcgagcaggagcaggaacaggaaGAGCAAATGGAGctggaaatgcaaatggatCTGGAgaaggaacagcagcagcagcagcagcagccaccctCCCCGGTGGCCATGCCCCAGTCGAGCCCGGAACTGCGTTGCAGTCGCTGTGCGAAGCAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCAggagctgcaacagcaacactatcaacaacagcaacagcagcagcaacaacaacagcaactccagcagcagcagcaactgcagcaaactCCTCGTTCCCTTTCCGAttacgatgacgacgacgatgtgGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcagcagctgaagcagcacTATGCCCACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCTGCCCATCTCCAACTGGATGCGCGGGTGGTCCAGGTGTGGTTTCAAAACAATCGCTCGCGGGAGCGCAAGCTGCAAAGCTACACAAGTGGCGGCGTTGGCAACACTGAGACGGCCTCGACAATCCCGGCCAGCTCTGCTGCACTGCCACCCCCACGTGGCGAGGATCAGCCCTTGGATTTGTCCCTCAAGCGGGATGCAACGCcgccgcagtcgcagttgcagaTGCCGCCGGATTACAGTGAGCCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCAGCTCTGCTGCGTCTGCCATGTCGCCAGCTTCCCtcgcagcggcggcggcggcaactCTTTACTTTGCCCCACCCTCGCCGACGGCGGGCCCGTTGCACAGCGCCACGCCTCCTTTGGGCGCACAGCGGGGCACGCCCTTTGCCGGTCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCCGGCGGCGAATATGCGCCGAATCCTCTGATGAACAGTATTAAACTGCCGGACTATCATCGCGGCACCAGCCTCAGCCCGGGTGGCTCCGAGAAGCGTTCGTGGCGTGACGATGATTCGCGCATTTCCCACGAGGATGACTATGTCCTGGCCACCGGTGGCCTGCTGGCCCCCAAACCGAGACGTGTCAAGGCCGAGACCCATGGCCACGCCGGCGATCCCGATCTGCCCTTCGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAACAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCTTATCAGTGCATGGACTGCACGAAGGCCTTCAAGCACAAGCATCATTTGACGGAGCACAAGCGATTGCATTCCGGTGAGAAGCCGTTTCAGTGCTCCAAGTGCTTGAAGCGCTTCTCGCACTCGGGCAGCTACAGTCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRCFGQEDNIIIQQSMPSSTAFSMQFPSLASSLHHHQTTTHNNSQPSNVAAASTEHVPHATSAATANAADECLVICPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPESEPEEEDEEEEHSNLSSSSNPRYAKSPSNNNNNNNNNNNNSHNNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPSNQQQQLQQQQQQQHQQQQQQQQLLQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHNREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPTKRSACKQLVEPVLPNLPMNYFAGDSQTSPVGVGVAGGAAAAVPPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQHQQQQQQQREEEEQHREQQELKREQEQELEREQEQEREREQQLQREQQEQQRTREQAQREQLQLLPSKQEEYAEEPKLVMDLEQDAEHPVAAATVEAKTAVKMEICRETTPQPTEALKAIKQEREQEQEQEEQMELEMQMDLEKEQQQQQQQPPSPVAMPQSSPELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQHYQQQQQQQQQQQQLQQQQQLQQTPRSLSDYDDDDDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTSGGVGNTETASTIPASSAALPPPRGEDQPLDLSLKRDATPPQSQLQMPPDYSEPSMAINLSRRQLSSSAASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLGAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRVKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCTKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00498768;