Basic Information

Insect: Drosophila neutralis
Gene Symbol: zfh1
Assembly: GCA_035044385.1
Location: JAWNME010000090.1:67617-96459[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0082 0.56 10.9 1.5 2 23 155 177 154 177 0.95

2 9 0.004 0.27 11.9 1.3 1 23 367 389 367 389 0.97

3 9 3.1e-05 0.0021 18.5 2.7 2 23 404 425 403 425 0.97

4 9 4.6e-05 0.0031 18.0 6.4 1 23 434 456 434 456 0.99

5 9 6e-05 0.0041 17.6 1.6 1 21 462 482 462 483 0.95

6 9 0.035 2.4 8.9 0.4 2 21 773 792 772 793 0.92

7 9 1.8e-05 0.0012 19.3 0.5 1 23 1135 1157 1135 1157 0.94

8 9 6.6e-05 0.0045 17.5 7.4 1 23 1163 1185 1163 1185 0.98

9 9 0.0033 0.22 12.1 4.3 1 21 1191 1211 1191 1212 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0082	0.56	10.9	1.5	2	23	155	177	154	177	0.95
2	9	0.004	0.27	11.9	1.3	1	23	367	389	367	389	0.97
3	9	3.1e-05	0.0021	18.5	2.7	2	23	404	425	403	425	0.97
4	9	4.6e-05	0.0031	18.0	6.4	1	23	434	456	434	456	0.99
5	9	6e-05	0.0041	17.6	1.6	1	21	462	482	462	483	0.95
6	9	0.035	2.4	8.9	0.4	2	21	773	792	772	793	0.92
7	9	1.8e-05	0.0012	19.3	0.5	1	23	1135	1157	1135	1157	0.94
8	9	6.6e-05	0.0045	17.5	7.4	1	23	1163	1185	1163	1185	0.98
9	9	0.0033	0.22	12.1	4.3	1	21	1191	1211	1191	1212	0.96

Sequence Information

Coding Sequence: ATGCTAGAATACTGCTACCGTCAGCCCAAGTTGCTTCAATTCATAAAGGGGTTCCAGTGGTCACATCCCAAGGCATCTCTGGACCCTGCCTCAGTCGCCTTCTCGTGTTGGTTGACCGCCAAGCGGATGCTTAACGGTTATCCGGGGGATACCTGGCCTACTGCCGGAGGTCACGAGTTGCTTGCACTACTCTGGACAAGAATCGCCTTGGTCATTGCCATGTTAATGACGATCAAGAACTTTCGCCTTATCCGAGTAGTGCCATCCCCGTGCCATATCAGTCGCCTCATACGACAAGCTACGGCCCGCTGTGGTGTTCCCTCTTTGGCGTCCAGTTTACACCATCACCaaagcacaacacacaacagcagccaggcCAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGCCGCATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGCCTGGTCAAATGCCCCCAATGCCACAAGCGCTTCAATGAGTTTCAGTCGTTTAGCGAGCACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCCGACAGCGAGCCCgaggaggacgaggaggaggaggaggagcacaGCAAtctaagcagcagcagccaacaacgcTATGCCAAATccccaagcaacaacaacaataacaacaacaacaacagcagtcacaacaacaacaacaacaataacagtgaAACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGCTGGGCTCCCCCGTTGCCCCCGCCACGCCCGGCGATCTGTTCGCCCATCTGCCACACCCAGCCgcccatttgcaatttgtggcagccGCCGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCGcccaacaaccaacagcaacagttgcaacaacagcagcaacaccagcagcagcaacagcaacagttgcagcagaagccgagcagcaacagcagcagcattggcagCAATTCCGCCTATGATCTGGATTTGAGTGCCCATCGTTCCACCTCGAGTCCGGGCTCTACGGCTGGCGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACGGCCAGCTTCCACAGTCGCGAGCAGCTCGAGCAACATCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCACAGAATGTCAAACAGACCTGCAAAATCTGTCACAAAACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCCGCGTTGCTGCGCAAATTCAAGTGCAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCATCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCGTTCAGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTAAAACTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCCGAGCAACTGCCTCCGGTTAAGCGCTCGGCCTGCAAACAGTTGGTGGAACCGGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGGGATTCACAAACATCACctgttggagttggagttgctggtggtgctgcagctgctgctccgcctcctcctccctTTTATTCCAACTATAGTGCAATGAATGCGGCTTTGTTGGCATTTCCCAATGCTTTTATGGCGGCTGCACTAGATCCACGCATGCATCCTTATAGCATACAGAGATTGCTGGAGTTAACAGCGGcaggacaacagcagcaccagcagcagcagcagcagagggagcaggaggagcatcacagagagcagcaggagctAAACagggagcaggagcaggaatTGGAAagggagcaggagcaggagagggagcagcagttgcaaagagaacaggagcagcagcagcgggagaGGGAACATGAGAGGGAGCAGGCGCATCGGGAGCAGTTGAAATTGGTGCCCAGCAAACAAGAGGATTACGCAGATGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCATCTAAAtagagcagctgcagcagcagcagcagaaaccaGGGCAGCTGTCAAAATGGAGATCAGTCGCGAGACAACGCCACATCCCGCAGAAGCAGTCAAGGCCATCAAGCAGGAGCGggaacaggagcaggaacaggagGAGCAAATGGAGCTGGACATGCAGATGGATCTggagaaggagcagcagcagcgatccTCCCCGGTGGCAATGCCCCAGTCAAGCCCCGAACTGCGCTGCAGTCGCTGTGCCAAGCAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacactatcaacaacagcaacaacagcagctccagcagcagcagcagcaactccagcaAACTCCGCGCTCCCTTTCCGatttcgacgacgacgaggatgTGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTACGCACACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTAGATGCGAGGGTTGTCCAGGTTTGGTTCCAGAACAATCGCTCGAGGGAGCGCAAGCTGCAAAGCTACACAAGTGGAGGGGCTGGCAACACCGAGACGGCCACGGCAATCCTGGCCAGCTCTGCTGCACTGCCTCCCGCACGTGGCGAGGATCAACCTTTGGATTTATCCCTCAAGCGGGATGCAACGCCGCCTCAgtcgcagctgcagctgccaccgGATTACAGTGAGGCCAGCATGGCCATCAACCTGAGTCGCCGTCAGTTGTCCAACTCGGCTGCGTCTGCCATGTCGCCTGCTTCGCtcgcagcggcggcggcggcaactcTTTACTTTGCCCCACCCTCACCGACGGCGGGCCCCTTGCACAGCGCCACGCCCCCTTTGGCAGCACAGCGAGGCACGCCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGGGAATATGCGCCCAATCCTCTGATGAACAGTATTAAATTGCCGGACTATCATCGCGGCACCAGCCTCAGCCCGGGTGGCTCCGAGAAGCGTTCGTGGCGCGACGATGACTCGCGCATCTCCCACGAGGATGACTACGTCCTGGCCACGGGCGGTCTGCTGGCGCCCAAGCCGAGGCGCGTCAAGGCCGAGACTCACGGACATGCCGGCGATCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGACTGCCCGAAGGCGTTCAAGCACAAGCACCATTTGACGGAGCACAAGCGATTGCATTCCGGCGAGAAGCCGTTCCAGTGCTCCAAGTGTCTGAAGCGCTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLEYCYRQPKLLQFIKGFQWSHPKASLDPASVAFSCWLTAKRMLNGYPGDTWPTAGGHELLALLWTRIALVIAMLMTIKNFRLIRVVPSPCHISRLIRQATARCGVPSLASSLHHHQSTTHNSSQASNVAAASTEHVPHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEEDEEEEEEHSNLSSSSQQRYAKSPSNNNNNNNNNSSHNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPGDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQQQQLQQQQQHQQQQQQQLQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTASFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQTSPVGVGVAGGAAAAAPPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQHQQQQQQREQEEHHREQQELNREQEQELEREQEQEREQQLQREQEQQQREREHEREQAHREQLKLVPSKQEDYADEPKLVMDLEQDAEHLNRAAAAAAAETRAAVKMEISRETTPHPAEAVKAIKQEREQEQEQEEQMELDMQMDLEKEQQQRSSPVAMPQSSPELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQHYQQQQQQQLQQQQQQLQQTPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTSGGAGNTETATAILASSAALPPARGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSNSAASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLAAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRVKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00558554;