Basic Information

Insect: Drosophila engyochracea
Gene Symbol: zfh1
Assembly: GCA_035042385.1
Location: JAWNLK010000104.1:1419512-1447402[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0071 0.45 11.0 1.5 2 23 87 109 86 109 0.95

2 9 0.0041 0.26 11.7 1.4 1 23 304 326 304 326 0.97

3 9 2.7e-05 0.0017 18.6 2.7 2 23 341 362 340 362 0.97

4 9 4e-05 0.0025 18.0 6.4 1 23 371 393 371 393 0.99

5 9 5.2e-05 0.0033 17.7 1.6 1 21 399 419 399 420 0.95

6 9 0.031 1.9 9.0 0.4 2 21 719 738 718 739 0.92

7 9 1.5e-05 0.00096 19.4 0.5 1 23 1076 1098 1076 1098 0.94

8 9 5.7e-05 0.0036 17.6 7.4 1 23 1104 1126 1104 1126 0.98

9 9 0.0028 0.18 12.2 4.3 1 21 1132 1152 1132 1153 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0071	0.45	11.0	1.5	2	23	87	109	86	109	0.95
2	9	0.0041	0.26	11.7	1.4	1	23	304	326	304	326	0.97
3	9	2.7e-05	0.0017	18.6	2.7	2	23	341	362	340	362	0.97
4	9	4e-05	0.0025	18.0	6.4	1	23	371	393	371	393	0.99
5	9	5.2e-05	0.0033	17.7	1.6	1	21	399	419	399	420	0.95
6	9	0.031	1.9	9.0	0.4	2	21	719	738	718	739	0.92
7	9	1.5e-05	0.00096	19.4	0.5	1	23	1076	1098	1076	1098	0.94
8	9	5.7e-05	0.0036	17.6	7.4	1	23	1104	1126	1104	1126	0.98
9	9	0.0028	0.18	12.2	4.3	1	21	1132	1152	1132	1153	0.96

Sequence Information

Coding Sequence: ATGCATGTGCCACAAGCTGCCTGCCTGACAGAGGACACACATATGCCCAGAAGAACAAGCAGCAACGAGcagcacaaacagcagcagcagcagcaggagtcgAAACTCTATTCAGTGACGGACACGGCTCGTTTACACCATCACCAaaccacaacacacaacaacagccaggCGAGCAATGTGGCCGCTGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCCCCAATGCCACAAGCGCTTCAACGAGTTTCAGTCCTTTAGTGAGCACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCTAGGCGCAGTTCAGCCCGACAGCGAGCCCGAGGCGGAGcccgaggaggaggaggaggatgaggaggaggagcacaGCAatctaagcagcagcagcaatcctCGCTATGCCAAATccccaagcaacaacaataataataacaacaacaacaacagtcacaataacaacatcaacaataataataacaatagcgAAACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGTTCCCCCATTGCCCCCGCTACGCCCAGTGATCTGTTCGCCCATCTGCCGCATCCTGACgcccatttgcaatttgtggcagCCGCTGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCACccaacaaccagcagcaacagttgcaaaaacaacatcaacagcagcaacagcagcagcaacagaagccgagcagcaacagcagcagcatcggcagCAATTCCGCCTACGATCTGGATTTGAGTGCCCATCGTTCCACCTCCAGTCCGGGCTCCACGGCTGGCGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACAGCCACCTTCCACAGTCGCGAGCAACTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAATGTGAAACAGACCTGCAAAATCTGCCACAAGACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCCGCGCTGCTGCGCAAGTTCAAGTGCAATCAATGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAACTCAATAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCCGAGCAACTGCCTCCGGTGAAGCGTTCGGCCTGCAAACAGTTGGTGGAACCAGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGGGATTCACAGTCATCACCCgtcggagttggagttggagttgctgGTGGTcctgcagctggagctgctcCTCCCCCTCCTCACTTTTATTCCAATTATAGCGCAATGAATGCGGCTCTGTTGGCATTTCCCAATGCTTTTATGGCGGCTGCTTTGGATCCACGCATGAATCCCTACAGCATACAGACATTGTTGGAGCTAACAGCGGcaggacaacagcagcagcagcagagggagcaggaggagcagcacagggagcagcaggagctgaaGAGGGAGCAGGAGCGGGAGCaggagcgggagcgggagcaGGAGTTGGAAagggagcaggagcaggagcaggaaagggagcagcagctgcaaagagagcacgagcagcagcagcagcaagcgcaGTTCGAGCAGGAGCGGAAGCGGgagcagttgcaattgctgccCAGCAAACAGGATGATTATTCAGAGGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCACCTAAacatcgcagcagcaacagcagcagaagcgagGACAGCTGTCAAAATGGAGATGAGTCGCGAGACAACGCCACAGCCCGTCGCAGCACTCACAGCCATCAAGCAGGAGcgggaacaggaacaggagcaaATGGAGCTGGACATGCAGATGGATCTGGAGAAGGAacagcaggaacaggagcagcagcagcagcaacagcagcaatcctCCCCCCAGTCAAGCACGGAGCTGCGCTGCAGTCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacagcaacactatcaacaacagcaacagcaactgcaacagcagcagcaaacttcTCGCTCCGTTTCCGACTTCGATGATGACGAGGATGTGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGACAGCAATGAGCGCAAGGTGCGCGTCCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTATGCCCACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATCGCAGCGCATCTCCAGCTGGATGCGAGGGTTGTCCAGGTGTGGTTCCAAAACAATCGCTCGCGGGAACGCAAGCTGCAGAGCTATACAGGTGGCGGGGCTGGCAACACTGAGACAGCATTGCTTGCCAGCTCTGCTGCACTGCCTCCGACACGTGGCGAGGATCAGCCGCTGGATTTGTCGCTGAAGCGGGATGCAACGCCGCCTCAGtcgcagctgcagttgccacCGGATTACAGCGAGGCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCAGCTCGACGGCGTCTGCCATGTCGCCGGCTTCTCtcgcggcggcggcggcggccaCTCTCTACTTTGCCCCACCCTCACCGACGGCGGGCCCCTTGCAcagtgccacgccccctttGGGGGCACAGCGTGGCGCACCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGTGAATATGCACCCAATCCACTGATAAACAGTATTAAATTGCCGGATTACCATCGCGGCACCAGCCTCAGTCCGGGTGGCTCCGAGAAGCGCTCGTGGCGCGACGACGACTCGCGCATCTCCCACGAGGACGACTATGTCCTGGCCACGGGTGGTCTGCTGGCGCCGAAGCCGCGGCGTGCCAAGGCCGAGACTCATGGCCATGCCGGGGACCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGATTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGATTGCATTCCGGCGAGAAGCCGTTTCAGTGTTCCAAGTGCCTGAAACGGTTCTCGCACTCGGGGAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MHVPQAACLTEDTHMPRRTSSNEQHKQQQQQQESKLYSVTDTARLHHHQTTTHNNSQASNVAAASTEHVAHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHLGAVQPDSEPEAEPEEEEEDEEEEHSNLSSSSNPRYAKSPSNNNNNNNNNNSHNNNINNNNNNSETAKNQNKRISHSPASLGSPIAPATPSDLFAHLPHPDAHLQFVAAAAMAMQSARSANSPNNQQQQLQKQHQQQQQQQQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQSSPVGVGVGVAGGPAAGAAPPPPHFYSNYSAMNAALLAFPNAFMAAALDPRMNPYSIQTLLELTAAGQQQQQQREQEEQHREQQELKREQEREQEREREQELEREQEQEQEREQQLQREHEQQQQQAQFEQERKREQLQLLPSKQDDYSEEPKLVMDLEQDAEHLNIAAATAAEARTAVKMEMSRETTPQPVAALTAIKQEREQEQEQMELDMQMDLEKEQQEQEQQQQQQQQSSPQSSTELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQQQQQLQQQQQTSRSVSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGGGAGNTETALLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSSSTASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLGAQRGAPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLINSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00501700;