Basic Information

Gene Symbol
zfh1
Assembly
GCA_035041595.1
Location
JAWNLB010000070.1:792552-812226[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.007 0.43 11.0 1.5 2 23 56 78 55 78 0.95
2 9 0.004 0.25 11.7 1.4 1 23 277 299 277 299 0.97
3 9 2.6e-05 0.0016 18.6 2.7 2 23 314 335 313 335 0.97
4 9 3.9e-05 0.0024 18.1 6.4 1 23 344 366 344 366 0.99
5 9 5.1e-05 0.0031 17.7 1.6 1 21 372 392 372 393 0.95
6 9 0.03 1.9 9.0 0.4 2 21 688 707 687 708 0.92
7 9 1.5e-05 0.00092 19.4 0.5 1 23 1053 1075 1053 1075 0.94
8 9 5.6e-05 0.0034 17.6 7.4 1 23 1081 1103 1081 1103 0.98
9 9 0.0028 0.17 12.2 4.3 1 21 1109 1129 1109 1130 0.96

Sequence Information

Coding Sequence
ATGCCAATAAGTCAAAGGCTGTGCCAGCTGAAGGGGGGTTTACACCATCACCAaaccacaacacacaacaacagccaggcGAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCCCCAATGCCACAAGCGCTTCAACGAGTTTCAGTCCTTTAGCGAGCACATTGCCAGCGAACATCCTCTGGACAAGCTGAACTATGAGCAGCCACATCCAGGCGCAGCTCAGCCCGACAGCGAGCCCGAGGCGGAGcccgaggaggaggatgaggatgaggaggaggagcacaGCAAtctaagcagcagcagcaatcctCGCTATGCCAAATCcccaagcagcaacaataataacaacaacaacagtcacaataacaacaacaataataataataacaataataatagtgaaaCGGCGAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGTTCCCCCGTTGCCCCCGCCACGCCCAGTGATCTGTTCGCCCACCTACCGCATCCTGCCgcccatttgcaatttgtggcagCCGCTGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCACCCAACAACCAGCaccaacagttgcaacagcaacatcaacagcagccacagcagcagcagcagcagcaacaacagaagccgagcagcaacagcagcagcattggcagCAATTCCGCCTACGATCTGGATTTGAGTGCTCATCGCTCCACCTCCAGTCCGGGCTCCACGGCTGGCGGAGATCTACTAGCTGCTGGCTTCCCCTGCATGCAGTGCACAGCCACCTTCCACAGTCGCGAACAACTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAATGTCAAACAGACCTGCAAAATCTGCCACAAGACATTTGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCCGCGCTGCTGCGGAAATTCAAGTGCAATCAATGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAACTCAATAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCCGAGCAACTGCCTCCGGTGAAGCGTTCGGCCTGCAAACAGTTGGTGGAACCAGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGGGATTCACAGTCATCACCAGTCGGAGTCGcagttggagctggagttgcTGGTGGCGctgtagctgcagctgctcctcctcctgccTTCTATTCCAGTTACAGCGCAATGAATGCGGCTCTATTGGCATTTCCCAATGCTTTTATGGCGGCTGCTTTGGATCCACGCATGCATCCCTACAGCATACAGAGATTGCTGGAGCTAACAGCGGcaggacaacagcagcagcagagggaGCAAGAGGAGCAGCACAgagagcagcaggagctgaaGAGGGAGCAggagcgggagcgggagcAGGAGTTGGAAAGGgtgcaggagcaggagcacgAGCAGGAGagggagcagcagctgcaacgagagcaggagcagcagcagaagcagttCGAGCAGGAGCGGAAGCGGgagcagttgcaattgctgccCAGCAAACAGGATGATTATGCAGAGGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCACCTAaacagcgcagcagcagcagaaacgaGCACAGCTGTCAAAATGGAGATGAGTCGCGACACAACGCCACAGCCCGTCGAAGCATTCACAGCCATCAAGCAGGAGCGGGAACAGGAaccggagcaggagcaggatgAGCACATAGAGCTGGACATGCAGATGGATCTGGAgaaggaacagcagcagcagcagcagcaggagcagcaatcCTACCCCCAGTCAAGCACGGAACTGCGCTGCAGTCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcagcagcaacactatcaacaacagcagcagcagcaacaacagcagcagcaacagcaactgcagcagcagcagcaaactccTCGCTCCGTTTCCGACTTCGATGACGACGAGGATGTGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTATGCCCACAATCCGCGGCCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTGGATGCGAGGGTTGTCCAGGTGTGGTTCCAAAACAATCGCTCGCGGGAACGCAAGCTGCAGAGCTATACAGGTGGCGGGGCTGGCAGCACTGAGACAGCATTGCTTGCCAGCTCTGCTGCTCTGCCTCCGACACGTGGCGAGGATCAGCCGCTGGATTTGTCGCTGAAGCGGGATGCAACGCCGCCTCAgtcgcagctgcagttgccacCGGATTACAGTGAGGCCAGCATGGCCATCAATTTGAGTCGCCGCCAGTTGTCCAGCTCGACGGCGTCTGCCATGTCGCCGGCTTCTCtcgcggcggcggcggcggccaCTCTCTACTTTGCCCCACCCTCACCGACGGCGGGCCCCTTGCAcagtgccacgcccccttTGGGGGCACAGCGTGGCGCACCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGTGAATATGCGCCCAATCCACTGATGAACAGTATTAAATTGCCGGATTACCATCGCGGCACCAGCCTCAGTCCGGGTGGCTCCGAGAAGCGTTCATGGCGCGACGACGACTCGCGCATCTCCCATGAGGACGACTATGTCCTGGCCACGGGTGGCCTGCTGGCGCCGAAGCCGCGGCGTGCCAAGGCCGAGACTCATGGCCATGCCGGGGACCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGATTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGATTGCATTCCGGCGAGAAGCCGTTTCAGTGTTCCAAGTGCCTGAAACGGTTCTCGCACTCGGGGAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCGTATAGGGAATAG
Protein Sequence
MPISQRLCQLKGGLHHHQTTTHNNSQASNVAAASTEHVAHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEAEPEEEDEDEEEEHSNLSSSSNPRYAKSPSSNNNNNNNSHNNNNNNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQHQQLQQQHQQQPQQQQQQQQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLLAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQSSPVGVAVGAGVAGGAVAAAAPPPAFYSSYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQREQEEQHREQQELKREQEREREQELERVQEQEHEQEREQQLQREQEQQQKQFEQERKREQLQLLPSKQDDYAEEPKLVMDLEQDAEHLNSAAAAETSTAVKMEMSRDTTPQPVEAFTAIKQEREQEPEQEQDEHIELDMQMDLEKEQQQQQQQEQQSYPQSSTELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQQQQQQQQQQQQQLQQQQQTPRSVSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGGGAGSTETALLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSSSTASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLGAQRGAPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00497631;
90% Identity
iTF_00577278;
80% Identity
iTF_00485758;