Basic Information

Insect: Drosophila seclusa
Gene Symbol: zfh1
Assembly: GCA_035043575.1
Location: JAWNMX010000257.1:1425858-1444186[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0073 0.46 11.0 1.5 2 23 64 86 63 86 0.95

2 9 0.0042 0.27 11.7 1.4 1 23 283 305 283 305 0.97

3 9 2.8e-05 0.0018 18.6 2.7 2 23 320 341 319 341 0.97

4 9 4.1e-05 0.0026 18.1 6.4 1 23 350 372 350 372 0.99

5 9 5.3e-05 0.0034 17.7 1.6 1 21 378 398 378 399 0.95

6 9 0.032 2 9.0 0.4 2 21 687 706 686 707 0.92

7 9 1.6e-05 0.001 19.4 0.5 1 23 1049 1071 1049 1071 0.94

8 9 5.8e-05 0.0037 17.6 7.4 1 23 1077 1099 1077 1099 0.98

9 9 0.0029 0.19 12.2 4.3 1 21 1105 1125 1105 1126 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0073	0.46	11.0	1.5	2	23	64	86	63	86	0.95
2	9	0.0042	0.27	11.7	1.4	1	23	283	305	283	305	0.97
3	9	2.8e-05	0.0018	18.6	2.7	2	23	320	341	319	341	0.97
4	9	4.1e-05	0.0026	18.1	6.4	1	23	350	372	350	372	0.99
5	9	5.3e-05	0.0034	17.7	1.6	1	21	378	398	378	399	0.95
6	9	0.032	2	9.0	0.4	2	21	687	706	686	707	0.92
7	9	1.6e-05	0.001	19.4	0.5	1	23	1049	1071	1049	1071	0.94
8	9	5.8e-05	0.0037	17.6	7.4	1	23	1077	1099	1077	1099	0.98
9	9	0.0029	0.19	12.2	4.3	1	21	1105	1125	1105	1126	0.96

Sequence Information

Coding Sequence: ATGCCAATAAGTCAAAGGCAACTGCCTGCTGAGGGGGAGGGGATTCCCTCTTTGGCGTCCAGTTTACACCATCACCAaaccacaacacacaacaacagccaggCGAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGCCGCATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGCCTGGTCAAATGCCCCCAATGCCACAAGCGCTTCAATGAGTTTCAGTCGTTTAGCGAACACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCCGAAAGCGAGCCCGAGgcggagcaggaggaggaggacgaggatgaggaggaggagcacaGCAAtctaagcagcagcagccaacaacgcTATGTCAAATccccaagcaacaacaataacaacaacaacaacaacagcagtcacaacaacaacaacaacaataacagtgaAACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGGTCCCCCGTTGCCCCCGCCACGCCCGGCGATCTGTTCGCCCATCTGCCACACCCTGCCgcccatttgcaatttgtggcagccGCCGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCAcccaacaaccaacagcaacagttgcaacaacagcagcaacaccagcagcagcagcagcaacaacaacagttgcagcagaagccgagcagcaacagcagcagcattggcagcAATTCCGCCTATGATCTGGATTTGAGTGCCCATCGTTCCACCTCGAGTCCGGGCTCCACGGCTGGTGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACGGCCACCTTCCACAGTCGCGAGCAGCTCGAGCAACATCAGCTGCTGCACTCGCCGACGCGGCAACACACAATCGCACAGAATGTCAAACAGACCTGCAAAATCTGTCACAAAACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCTGCGCTGCTGCGCAAATTCAAGTGCAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCATCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTGAAACTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCGGAGCAACTGCCTCCGGTGAAGCGCTCGGCCTGCAAACAGTTGGTGGAACCGGTTCTCCCAAATCTGCCCATGAATTATTTTGCTGGGGATTCACAAACATCGCctgttggagttggagttgctggtggtgctgcagctgctgctcctcctcctcctcccttTTATTCCAACTATAGTGCAATGAATGCGGCTTTGTTGGCATTTCCCAATGCTTTTATGGCGGCTGCTCTAGATCCACGCATGCATCCTTATAGCATACAGAGATTGCTGGAGTTAACAGCGgcaggacaacaacagcagcagcagcagcagagggaGCAGGAGGAGCATCACAGagagcagcaggagctgaaCAGGGAGCAGGAATTGGAAagggagcaggagcaggagagggagcagcagttgcaaagagaacaggagcagcagcagcgggagagggagagggaacATGAGAGGGAGAAGGCGCATCGGGAGCAGTTGAAATTGGTGCCCAGCAAACAGGAGGATTACGCAGATGAGCCCAAGCTGGTCATGGATCTTGAACAGGATGCAGAGCATCTAAAtagagcagctgcagcagcagcagcagaaaccaGGGCAGCTGTCAAAATGGAGATCAGTCGCGAGTCAACGCCACATCCCGCAGAAGCAGTCAAAGCCATCAAGCAGGAGcgggaacaggagcaggaacaggagGAGCAAATGGAGCTGGACATGCAGATGGATCtggagaaggagcagcagcaacaatcctCCCCGGTGGCAATGCCCCAGTCAAGCCCCGAACTGCGCTGCAGTCGCTGTGCCAAGCAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacactatcaacaacagcaacaacagcagctccagcagcagcagcagcaactccagcAAACTCCGCGCTCCCTTTCCGAtttcgacgacgacgaggatgtggaggagctgctggagGAGCCACGCCACGCGGACTATGCCGCCGGCAGCAGTGATAGTAATGAGCGCAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcaacagctcaagCAGCACTACGCACACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTGGATGCGAGGGTTGTCCAGGTGTGGTTCCAAAACAATCGCTCGAGGGAGCGCAAGCTGCAAAGCTACACAAGTGCCGGGGCTGGCAACACTGAGACGGTCACGGTAAGCATGGCCAGCTCTGCTGCACTGCCGCCCGCACGTGGCGAGGATCAACCTTTGGATTTATCCCTCAAGCGGGATGCAACGCCGCCTCAgtcgcagctgcagctaccACCGGATTACAGTGAGGCCAGCATGGCCATCAACCTGAGTCGCCGTCAGTTGTCCAACTCGGCTGCGTCTGCCATGTCGCCTGCTTCGCtcgcggcggcggcggcggcaactcTTTACTTTGCCCCACCCTCACCGACGGCGGGCCCCTTACACAGCGCCACGCCCCCTTTGGCAGCACAGCGAGGCACGCCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGGGAATATGCGCCCAATCCTCTGATGAACAGTATTAAATTGCCGGACTATCATCGCGGCACCAGCCTCAGTCCGGGTGGCTCCGAGAAGCGTTCGTGGCGCGACGATGACTCGCGCATCTCCCACGAGGATGACTATGTCCTGTCCACGGGCGGTCTGCTGGCGCCCAAGCCGAGGCGCGCCAAGGCCGAGACTCATGGACATGCCGGCGATCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCAGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGACTGCCCGAAGGCGTTCAAGCACAAGCACCATTTGACGGAGCACAAGCGATTGCATTCCGGTGAGAAACCGTTCCAGTGTTCCAAGTGCCTGAAGCGCTTCTCGCACTCGGGCAGCTACAGTCAGCACATGAACCACCGCTACTCCTACTGCAAGCCATACAGGGAATAG
Protein Sequence: MPISQRQLPAEGEGIPSLASSLHHHQTTTHNNSQASNVAAASTEHVPHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPESEPEAEQEEEDEDEEEEHSNLSSSSQQRYVKSPSNNNNNNNNNSSHNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPGDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQQQQLQQQQQHQQQQQQQQQLQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQTSPVGVGVAGGAAAAAPPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQQQREQEEHHREQQELNREQELEREQEQEREQQLQREQEQQQREREREHEREKAHREQLKLVPSKQEDYADEPKLVMDLEQDAEHLNRAAAAAAAETRAAVKMEISRESTPHPAEAVKAIKQEREQEQEQEEQMELDMQMDLEKEQQQQSSPVAMPQSSPELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQHYQQQQQQQLQQQQQQLQQTPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTSAGAGNTETVTVSMASSAALPPARGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSNSAASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLAAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLSTGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00592989;