Basic Information

Insect: Drosophila heteroneura
Gene Symbol: zfh1
Assembly: GCA_035042245.1
Location: JAWNLO010000681.1:18515-40923[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0069 0.44 11.0 1.5 2 23 54 76 53 76 0.95

2 9 0.004 0.25 11.7 1.4 1 23 297 319 297 319 0.97

3 9 2.6e-05 0.0017 18.6 2.7 2 23 334 355 333 355 0.97

4 9 3.9e-05 0.0025 18.1 6.4 1 23 364 386 364 386 0.99

5 9 5.1e-05 0.0032 17.7 1.6 1 21 392 412 392 413 0.95

6 9 0.03 1.9 9.0 0.4 2 21 691 710 690 711 0.92

7 9 1.5e-05 0.00095 19.4 0.5 1 23 1052 1074 1052 1074 0.94

8 9 5.6e-05 0.0035 17.6 7.4 1 23 1080 1102 1080 1102 0.98

9 9 0.0028 0.18 12.2 4.3 1 21 1108 1128 1108 1129 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0069	0.44	11.0	1.5	2	23	54	76	53	76	0.95
2	9	0.004	0.25	11.7	1.4	1	23	297	319	297	319	0.97
3	9	2.6e-05	0.0017	18.6	2.7	2	23	334	355	333	355	0.97
4	9	3.9e-05	0.0025	18.1	6.4	1	23	364	386	364	386	0.99
5	9	5.1e-05	0.0032	17.7	1.6	1	21	392	412	392	413	0.95
6	9	0.03	1.9	9.0	0.4	2	21	691	710	690	711	0.92
7	9	1.5e-05	0.00095	19.4	0.5	1	23	1052	1074	1052	1074	0.94
8	9	5.6e-05	0.0035	17.6	7.4	1	23	1080	1102	1080	1102	0.98
9	9	0.0028	0.18	12.2	4.3	1	21	1108	1128	1108	1129	0.96

Sequence Information

Coding Sequence: ATGATCACTAAAgTTCCCTCTTTGGCGTCCAGTTTACACCATCACCaaagcacaacacacagcaacagccaggCGAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCCCCAGTGCCACAAGCGCTTCAACGAGTTTCAGTCATTTAGCGAGCACATTGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCATCCAGGCGCAGCTCAGCCCGACAGCGAGCCCGAGGCGGAgcccgaggaggaggaggaggacgaggaggaggagcacaGCAatctgagcagcagcagcaatcctCGCTATGCCAAGTccccaagcaacaacaacaacaacaataacaacaacagtcacaacaataacaacaaccacaacaaccataacaataataataataataataataatagtgaaACGGCAAAGAATCAAAATAAACGCATTTCACATTCACCTGCCTCGTTGGGCTCCCCCGTCGCCCCCGCCACGCCCAGTGATCTGTTCGCCCACCTGCCGCATCCTGCCGcccatttgcaatttgtggcagCCGCTGCGATGGCCATGCAATCGGCACGCTCAGCCAACTCAcccaacaaccaacagcagcagttgcaacaacaacagcaacagcagcaacagttgcaacaacagcagcagcagcaacagttgcaacaacagcagcagcagcaacagcagcagcagcaacagaagccgagcagcaacagcagcagcatcggcagCAATTCCGCCTACGATCTGGATCTGAGTGCCCATCGTTCCACCTCCAGTCCGGGCTCCACGGCTGGCGGAGATCTCCCAGCTGCTGGCTTCCCCTGCATGCAGTGCACAGCCACCTTCCACAGTCGCGAGCAGCTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAACGTCAAACAGACCTGCAAGATCTGCCACAAGACATTCGCGAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCGGCGCTGCTGCGCAAATTCAAGTGCAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAGCTGAACAACAATCGCCAGCTGCTCAAAACGCTGGACAAGAATGCCGAGCAGCTGCCTCCGGCTAAGCGTTCGGCCTGCAAACAGTTGGTGGACCCAGTTCTCCCAAATCTGCCCATGAACTATTTCGCTGGCGATTCACAGTCATCGccagttggagttggagttggagttgctggtgccgctgcagctgctgctgctgctccgcctCCTCCCTTTTATTCCAATTATAGTGCAATGAATGCGGCTCTGCTGGCGTTTCCCAATGCTTTCATGGCGGCTGCCTTGGATCCACGCATGCATCCCTACAGCATACAGAGATTGCTGGAGCTGACAGCGGccggacagcagcagcagcagcagagggagcaggaggagcagcacagagagcagcaggagctgaaGAGGGAGcaggagcgggagcgggagcagGAGTTGGAAagggagcaggagcaggagcaggagcgggagcagcagctgcaaagagagcagcagcagcagcaggagcaggcgcAGCGGgagcagttgcaattgctgcccAGCAAACAGGATGATTATGCAGAGGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCACCCAAatagcgcagcagcagccgcagcagcaggagcagaaacGAGAACAGCTGTCAAAATGGAGATGAGTCGCGAGACAACGCCACAGCCCGTGGAAGCACTCGCAGCCATCAAGCAGGAGCGGGAACAGGAGCAGgaacagcaggagcagcagcagcagcagcagctgctgcaatccTCCCCCCAGCCAAGCCAGGAACTGCGCTGCAGTCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcagcagcaacactatcaacaacagcagcagcagcagcaacagcagcagcagctgcagcagcaagctCCTCGCTCCCTTTCCGActtcgatgatgatgaggatgtgGAGGAGCTGCTGGAGGAGCCGCGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTCCGCACCGCCATCaacgaggagcagcagcagcagctgaagcagcacTATGCCCACAATCCGCGACCAAGTCGCGACGAGTTCCGCCGGATTGCAGCGCACCTCCAGCTGGATGCGCGGGTTGTCCAGGTCTGGTTCCAGAACAATCGCTCGCGGGAACGCAAGCTGCAGAGCTATACGGGTGGCGGGGCTGGCAGCGCTGAGCCAGCATTGCTGGCCAGCTCTGCTGCACTGCCGCCGACACGTGGCGAGGATCAGCCGCTGGACTTGTCGCTGAAGCGGGACGCAACGCCGCCCCagtcgcagctgcagctacCACCGGACTACAGTGAGGCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCGGCTCGACGGCGTCCGCCATGTCGCCGGCTTCCCtcgcggcggcggcggcggccaCGCTCTACTTTGCCCCGCCCTCGCCGACGGCGGGCCCCTTGCACAGTGCCACGCCCCCGTTGGGGGCACAGCGTGGCACACCCTTCGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCGATGGAGGCGCTCTTCCAGATGCGCCCGGGCGGTGAATACGCACCCAATCCGCTGATGAACAGTATTAAATTGCCGGACTATCATCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCCCACGAGGACGACTACGTCCTGGCCACGGGCGGTCTGCTGGCGCCGAAGCCGCGGCGCGCCAAGGCCGAGACCCATGGCCATGCCGGCGACCCCGATCTGCCCTTCGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCTTGGCCCGGCACAAATACGAGCATTCCGGTCAGCGACCGTACCAGTGCATGGACTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGACTGCATTCCGGCGAGAAGCCGTTCCAGTGCTCCAAGTGCCTGAAACGGTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MITKVPSLASSLHHHQSTTHSNSQASNVAAASTEHVAHATSAATANAADECLVKCPQCHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEAEPEEEEEDEEEEHSNLSSSSNPRYAKSPSNNNNNNNNNSHNNNNNHNNHNNNNNNNNNSETAKNQNKRISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNNQQQQLQQQQQQQQQLQQQQQQQQLQQQQQQQQQQQQQKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPAKRSACKQLVDPVLPNLPMNYFAGDSQSSPVGVGVGVAGAAAAAAAAPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQREQEEQHREQQELKREQEREREQELEREQEQEQEREQQLQREQQQQQEQAQREQLQLLPSKQDDYAEEPKLVMDLEQDAEHPNSAAAAAAAGAETRTAVKMEMSRETTPQPVEALAAIKQEREQEQEQQEQQQQQQLLQSSPQPSQELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQQQQQQQQQQQLQQQAPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGGGAGSAEPALLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSGSTASAMSPASLAAAAAATLYFAPPSPTAGPLHSATPPLGAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00518340;