Basic Information

Insect: Drosophila picticornis
Gene Symbol: zfh1
Assembly: GCA_035043845.1
Location: JAWNMR010000156.1:5145904-5165954[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0033 0.2 12.1 1.2 2 23 66 88 65 88 0.95

2 9 0.0042 0.26 11.7 1.4 1 23 288 310 288 310 0.97

3 9 2.7e-05 0.0017 18.6 2.7 2 23 325 346 324 346 0.97

4 9 4.1e-05 0.0025 18.1 6.4 1 23 355 377 355 377 0.99

5 9 5.3e-05 0.0033 17.7 1.6 1 21 383 403 383 404 0.95

6 9 0.031 1.9 9.0 0.4 2 21 694 713 693 714 0.92

7 9 1.6e-05 0.00096 19.4 0.5 1 23 1070 1092 1070 1092 0.94

8 9 5.8e-05 0.0036 17.6 7.4 1 23 1098 1120 1098 1120 0.98

9 9 0.0029 0.18 12.2 4.3 1 21 1126 1146 1126 1147 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0033	0.2	12.1	1.2	2	23	66	88	65	88	0.95
2	9	0.0042	0.26	11.7	1.4	1	23	288	310	288	310	0.97
3	9	2.7e-05	0.0017	18.6	2.7	2	23	325	346	324	346	0.97
4	9	4.1e-05	0.0025	18.1	6.4	1	23	355	377	355	377	0.99
5	9	5.3e-05	0.0033	17.7	1.6	1	21	383	403	383	404	0.95
6	9	0.031	1.9	9.0	0.4	2	21	694	713	693	714	0.92
7	9	1.6e-05	0.00096	19.4	0.5	1	23	1070	1092	1070	1092	0.94
8	9	5.8e-05	0.0036	17.6	7.4	1	23	1098	1120	1098	1120	0.98
9	9	0.0029	0.18	12.2	4.3	1	21	1126	1146	1126	1147	0.96

Sequence Information

Coding Sequence: ATGAGATCATCGCCTTTTACGTGGAAACGTTGCGTGAAGGCAACGCCAAGCCACAATGCCAATAAGTCAAAGGCTTTGGCAACTGAGGGGGGAGAGGGcaacagccaggCGAGCAATGTGGCCGCAGCCAGTACGGAGCATGTGGCACATGCAACCAGTGCCGCCACAGCGAATGCGGCCGATGAGTGTCTGGTCAAATGCCCCGAGTGCCACAAGCGCTTCAACGAGTTTCAGTCCTTTAGCGAGCACATCGCCAGCGAGCATCCGCTGGACAAGCTGAACTATGAGCAGCCGCACCCAGGCGCAGCTCAGCCCGACAGCGAGCCCGAGGCGGAgcccgaggaggaggaggaggaggatgaggaggaggagcacaGCAAtctaagcagcagcagcaatcctCGCTATGCCAAGTccccaagcagcaacaacaacaacaacatcaacagtcacaataacaacaacaacaacaacaacaacaacaataatagtgAAACGGCAaagaatcaaaacaaacacatttcacattcaCCTGCCTCGTTGGGTTCCCCCGTTGCCCCCGCCACGCCCAGTGATCTGTTCGCCCATCTGCCGCATCCTGCCGcccatttgcaatttgtggcagCCGCTGCGATGGCCATGCAATCGGCACGCTCGGCCAACTCtcccaacagccaacagcaacagttgcaacaacagcagcagcagcaacagcagcaacagcagcagcagcagcaacggaagccgagcagcaacagcagcagcatcggcagcaaTTCCGCCTACGATCTGGATTTGAGTGCCCATCGTTCCACCTCCAGTCCGGGCTCCACGGCTGGCGGAGATCTGCCAGCCGCTGGCTTCCCCTGCATGCAGTGCACGGCCACCTTCCACAGTCGCGAGCAACTCGAGCAACACCAGCTGCTGCACTCGCCGACGCGGCAGCACACAATCGCCCAGAATGTCAAACAGACCTGCAAAATCTGCCACAAGACGTTTGCAAATGTGTATCGCCTGCAGCGGCACATGATTAGCCACGATGAGTCCGCGCTGCTGCGCAAATTCAAGTGCAATCAGTGCGAGAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTCAGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCGGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATCAGCATGTGCCTCAAACTGAATAACAATCGCCAGCTGCTCAAGACGCTGGACAAGAATGCGGAGCAACTGCCTCCGGTGAAGCGTTCGGCCTGCAAACAGTTGGTGGAACCTGTTCTCCCAAATCTGCCCATGAATTACTTTGCTGGGGACTCACAGTCATCGccagttggagttggagttggagttgctggtggtgctgcagctgctgctgctcctcctcctcccttTTATTCCAATTATAGTGCAATGAATGCGGCTCTGTTGGCATTTCCCAATGCTTTTATGGCCGCTGCTTTGGATCCACGCATGCATCCCTATAGCATACAGAAGCTGCTGGAGCTGACGGCGGcaggacagcagcagcagcagcaacagcagcagagggagcaggaggagcagcaggagctgaaAAGGGAGCAGAATCGGGAGCGGGAGCAGGAGTTGGAAAgggagctggagcaggagcaggagagggagcagcagctgctaagagagcaggagcagcagcagcagcaggagcagttTGAGCAGGAACGGAAGCGggagcaattgcaattgctgcccAGCAAACAGGATGATTATGCAGAGGAGCCCAAGCTGGTCATGGATCTGGAACAGGATGCAGAGCACCTAAatagcgcagcagcagcagcagcagcagaaacgaGAACAGCTGTCAAAATGGAGATCAGTCGCGAGACAACGCCACAGCCGCTGGAAGCACTCGCAGCCATCAAAGAGGAGcgggaacaggaacaggagcaggaggagcaaATGGAGCTCGACATACAGATGGATCTGGAGAaggagcagcaccagcagcaggaaTCCTCCCCCCAGTCAAGCCAGGAACTGCGCTGCAGCCGCTGTGCCAAACAATTCAATCATCCCACCGAGCTGGTGCAGCACGAGAAAGTGCTCTGTGGCCTGATCAAGCaggagctgcaacagcaacagcaacactatcaacaacaccaacagcagcagcagcagcaactgcagcagcagcaactgcagcaacagcaactgcagcaacagcaactgcagcagcagcagcaagctcCTCGCTCCCTTTCCGACTTCGATGACGACGAGGATGTGGAGGAGCTGCTGGAGGAGCCACGCCACGCGGACTACGCCGCCGGCAGCAGTGATAGCAATGAGCGCAAGGTGCGCGTTCGCACCGCCATCaacgaggagcagcagcagcagctcaagcaGCACTATGCCCACAATCCGCGACCAAGTCGCGATGAGTTCCGCCGGATTGCAGCGCATCTCCAGCTGGACGCGAGGGTTGTCCAGGTGTGGTTCCAAAACAATCGTTCGCGGGAACGCAAGCTGCAAAGCTACACGGGTGTCGGGGCTGGCAGCACTGAGACAGCTTTGCTTGCCAGCTCTGCTGCACTGCCTCCGACACGTGGCGAGGATCAGCCGCTGGATTTGTCGCTGAAGCGGGATGCAACGCCgccgcagtcgcagctgcagctgccgccggATTACAGTGAGGCCAGCATGGCCATCAATCTGAGTCGCCGCCAGTTGTCCAGCTCGACGGCGTCTGCCATGTCGCCGGCTTCTCtcgcggcggcggcggcggccaCCCTCTACTTTGCCCCACCCTCGCCGACGGCGGGCCCCTTGCACAGTGGCACGCCCCCCTTGGGGGCACAGCGTGGCACACCCTTTGCCGGCCTGCCGCCCTTTCCCATGATGGCCCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGTCCGGGCGGCGAATACGCACCCAATCCACTGATGAACAGTATTAAATTGCCGGATTACCATCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGATTCGCGCATCTCCCACGAGGACGACTACGTCCTGGCCACGGGTGGCCTGCTGGCGCCGAAGCCGCGGCGTGCCAAGGCCGAGACCCATGGCCATGCCGGGGATCCCGATCTGCCCTTTGTGTGTGATCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCCCGGCACAAATACGAGCATTCCGGTCAGCGACCGTATCAGTGCATGGATTGCCCGAAGGCGTTCAAGCACAAGCACCACTTGACGGAGCACAAGCGATTGCATTCCGGCGAGAAGCCGTTCCAGTGCTCCAAGTGCCTGAAGCGGTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MRSSPFTWKRCVKATPSHNANKSKALATEGGEGNSQASNVAAASTEHVAHATSAATANAADECLVKCPECHKRFNEFQSFSEHIASEHPLDKLNYEQPHPGAAQPDSEPEAEPEEEEEEDEEEEHSNLSSSSNPRYAKSPSSNNNNNINSHNNNNNNNNNNNNSETAKNQNKHISHSPASLGSPVAPATPSDLFAHLPHPAAHLQFVAAAAMAMQSARSANSPNSQQQQLQQQQQQQQQQQQQQQQRKPSSNSSSIGSNSAYDLDLSAHRSTSSPGSTAGGDLPAAGFPCMQCTATFHSREQLEQHQLLHSPTRQHTIAQNVKQTCKICHKTFANVYRLQRHMISHDESALLRKFKCNQCEKAFKFKHHLKEHVRIHSGEKPFSCDNCGKRFSHSGSFSSHMTSKKCISMCLKLNNNRQLLKTLDKNAEQLPPVKRSACKQLVEPVLPNLPMNYFAGDSQSSPVGVGVGVAGGAAAAAAPPPPFYSNYSAMNAALLAFPNAFMAAALDPRMHPYSIQKLLELTAAGQQQQQQQQQREQEEQQELKREQNREREQELERELEQEQEREQQLLREQEQQQQQEQFEQERKREQLQLLPSKQDDYAEEPKLVMDLEQDAEHLNSAAAAAAAETRTAVKMEISRETTPQPLEALAAIKEEREQEQEQEEQMELDIQMDLEKEQHQQQESSPQSSQELRCSRCAKQFNHPTELVQHEKVLCGLIKQELQQQQQHYQQHQQQQQQQLQQQQLQQQQLQQQQLQQQQQAPRSLSDFDDDEDVEELLEEPRHADYAAGSSDSNERKVRVRTAINEEQQQQLKQHYAHNPRPSRDEFRRIAAHLQLDARVVQVWFQNNRSRERKLQSYTGVGAGSTETALLASSAALPPTRGEDQPLDLSLKRDATPPQSQLQLPPDYSEASMAINLSRRQLSSSTASAMSPASLAAAAAATLYFAPPSPTAGPLHSGTPPLGAQRGTPFAGLPPFPMMARLPMEALFQMRPGGEYAPNPLMNSIKLPDYHRGTSLSPGGSEKRSWRDDDSRISHEDDYVLATGGLLAPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00497631;
90% Identity: iTF_00577278;
80% Identity: iTF_00576240;