Dbir017822.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila birchii
Gene Symbol
L
Assembly
GCA_008042755.1
Location
VNKA01007167.1:208278-215220[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 9.5e-06 0.00077 19.9 2.9 1 23 158 180 158 180 0.98
2 17 0.14 12 6.7 7.3 1 23 186 208 186 208 0.97
3 17 1.6e-07 1.3e-05 25.5 3.2 1 23 214 236 214 236 0.99
4 17 1.2e-05 0.00094 19.6 0.4 1 23 242 264 242 264 0.99
5 17 0.011 0.92 10.2 0.2 2 23 345 369 344 369 0.92
6 17 0.0014 0.11 13.0 0.4 2 23 391 413 390 413 0.96
7 17 0.058 4.7 8.0 0.7 1 23 501 523 501 523 0.97
8 17 0.0039 0.32 11.6 0.1 2 23 531 552 530 552 0.92
9 17 8.8e-05 0.0071 16.8 0.4 1 23 560 584 560 584 0.94
10 17 4.7 3.8e+02 2.0 0.9 2 23 620 642 619 642 0.94
11 17 0.0024 0.19 12.3 1.1 1 23 687 710 687 710 0.97
12 17 0.0047 0.38 11.4 1.2 2 23 899 921 898 921 0.96
13 17 0.038 3 8.5 0.1 1 23 927 949 927 949 0.92
14 17 0.045 3.7 8.3 0.1 2 23 957 978 956 978 0.96
15 17 0.69 56 4.6 0.5 2 23 1083 1104 1083 1104 0.94
16 17 0.009 0.73 10.5 0.0 1 23 1114 1136 1114 1136 0.96
17 17 0.00016 0.013 16.0 1.7 1 23 1143 1165 1143 1165 0.98

Sequence Information

Coding Sequence
ATGATGGCCCTAAAGATGTTATATCGCGGTCCCAGTTCGCGTTTggagaatttaattgaaaagatCCAGGCCACCAAGGAGATAACCAATAGCGACATGTATAGTACCCACACATCATCCAGCTACTCGCCCAGCATTTCGGATGGCACCATGACGCCCAATTCCCACCATTTGCCCGGAGCTCTCACCTCCGCCGCTGCCTCTGGCCAGGAGGATCATCATCATTCCGATGGCAAACTCAATGGTGGCACCGATGGCGAAGAATTGGCCAAACCAAAGCGTTTGCCACactttcatcatcatcaccatcatcattaCCACCATCAGCAGGCGCTGAAAATCGCCAACAAGCTGCGCAAAATCAATAAGGAAGCCAAAATGGGAGCTGGCGGCGGTGCTGGTGCCGGAGGAGCTGGCTCCAAGTTTGATAAGTTGACAGGCGAGGGGATTAAGGCTCGCGGCGACGGCTCCTATCAGTGTCAGTTCTGCGATAAGTCATTTCCGCGTCTCGGCTACTTGAAGCATCACGTGCAGAGCCACGCCGAACACCTGCCCTTCAAGTGCGAATACTGCTCGAAGCTGTTCAAGCACAAGCGTTCCCGGGATCGCCACAAGAAGCTGCATACCAACGAGCGTAACTACAAGTGTCCCCATTGCGAGGCGGCCTTCTCCAGGAGTGACCACCTGAAGATCCACATGAAGACCCACGACATCCAGAAGCCGTTCCAGTGCAGCATGTGCAACCGTGGCTATAATACGGCGGCTGCCCTGACCTCGCACATGCAGAAGCACAAGAAGAATGCGGCCATCCTGGCAGCTGGTGGCAATCCCAATGCCCTGAACTATAGTCCCCGTTCAACGGGATCGGCCTCGGCCTCAGTCTCCAGCAATGGCAGTCTACAAAAGAGGCGATATGCCTTGGCCCTGGCCTCGGATAGTAGTCCCAGTCGGCTGGACTTTCCCAAAAGATCCAGGAGCAGTCATGTGGGTGGTAGCAACACCACTGCAACGGCCACACCCACTCCACTGCTGAGGTGCAGCTACTGTCCCAAAGTCACGGAGTTTAGCAGCTTGGAGCAGCTGAATGCCCACCTGCAGAGTGTCcacgagcagcagcatcagcatgcAGCAAAGACTCCCACAGCTCCCGAAAGTGAAGGCTTCCAGCTGAGCTGCGAATATTGCACCATGAAGTTCGGTAATATAGCCGGATTATTCCAGCACATGAGGAGCACTCACCTGGACAGATTGAGCAGTCCAAACTCCTACTACGAGCACTTCAATCGCCTGGCCACTGCTGGCACTTTCAGCCCCCGCTTGGCTTTGGATTTGCCCAAAATCAAACCGGATTTGGGCAGCCCAGAGAGGGAAACAACTCGTGCAGCCGAGGAGGATTTGCCCACCGATTTGAGCAGCAACAAGAGGCGATCCCAGACACCCACAAATAACCAGCAGTTGCAGTCCCAACAACTGGCTCCGCCAACTGCTCCTCCCGGAGTGTTCTTTTGCAATCAATGCAACGCTGGTCTGCCGGATTTCGAGAGCTTCAGGAATCACCTAAAGAGTCACATTGCTGAGGGCATGCAAATGGTGTGTCCCCATTGCGGTTTGAGTTTGCCCGAGCAGTCGGAGTTCGAGCGCCATGTGGTGGGGCACTTCCTCATCACCGGCTCCGAGTTCAATTGCAGCTCCAGCTGCGGCAAGAGCTTTGCCAAGTCGGAGGatctgcagcagcatctgTTGTCTGACCATGTGCTCACCCTGCTGAAGTGCTCGTTATGCTCGGAGCTCTGCGAAAGTCGAATGGCCATGCAGCTGCATTTGGCCTGTGCCCACAGCCAGGAGACAAAGCTTCTACGCTGCAGCGCCTGCCTGGAGCTCTTCCGCTCGGATGCCGAGTTCCATGTGCATGTGAAGACGCGTCACCAGTTGGGCGGTCATCCCGCCATAGGCGCCACACCCAGTGCTCCTGCCAATCCCCTGCAGTGCATGTTCTGCCGGGCTGTCTGCTCCTCAGAGCTGGAGATGCATTTCCATTTGGCGGCGCACGCCAGGCAGTTTAGGTGTCCCTCCTGCCCGGAGACCTTCCATGTGGAGTTCCTGCTGGATAGGCACATGCAGAGCCAGCATGGTGGCGGCGTAAAGGACAAGGAACAGCAACGTGGCTCACCCAACATGGGCAGTCTCTATGTGAATGCGTTGCTGCCGCCTTTGgccgcagcggcggcggcagcagcggccaccaataacaacagcagcatcattGACTACAATGTGGCTTTTAAGGGTTTGTTTGGCGGCGGAGctggcggaggagcagcaTCTGGTGCGGGGTCAGGATCAGGAGGAGGCTCTGGAGCAGCCCCACCTTCAAACAACAAATTCTACAGTCCCCTGCAGGTGGACACGAATGCTTTGAAGGCTCAAGCCTCACCGCATCCCGCTCTCATGTACGGCCTGAGTCAACGATATCTGATGGAGATGTATGCCGCCAAGTCCACATCCCCAGCGGGTGGCAATGAGGGTAATCCACAGCCACCACAGGCAACGGCTCCGCCAAGTGCTCCACCGAGTGCAGCTCCAGCCACTGCCACCTTCAGTTGTGGCATGTGCGAGCGTCAGGATCTACGCAGCGAGGCGGAGCTCCATTCGCACCGCAAGCTGGCCCACAATCTCAAGACGGGTGTGAGCCTGAGATGTGCCTACTGTGCCGGGAACTTCAAGTCACGAgcggagctggagcagcacaTGAAGAGCTGCCACAATTCCACGGGCAAGCACAAGTGCCTGATCTGCGATGAAGTCTTCCCCTCGCCGGCCATCCTGGCCGAGCACAAGCTGCAGCACTCCAAGGTGGGTCAGTCTGGGAAATGCTCCCATTGCGGTCAGCCGCTGGAGGATGTGGCCGCCTTCAGGGCACATCTCTCAGAGCATGGCAGCGATGGGGCCACCCTGCCGCTGGCCTGCATCTGCTGTCGCCAGACTCTGCACTCGGAGTTCGAGCTGAGTCTGCACGCCAAGTTCCACACCAAGTCGGCCTCGAGCGGTGGTAGCCTCCAGGAGCCGGTGTGTGCTCTTTGCCTGGAGCCATTGCCCGATGTACCCGTCGAGGGTCCAGCCAAGCTGTGCGAGAAATGCTGTCGGAAGCATAATCTTAATGGAAAGCGGGGAAAGCCAAGTGACCCGCAGCTGCAGGCACCCCCATCAgccggaggagctggagcaggagctgcctTTGTGGAGAACCGCTGCAATCTGTGCAAAATGATCCTGCCGCATGCCCAGAAGCTGCAAGAACACCTGGTGGAGCACACCTTTGCGGGCACCGAGCAGCGCGGCTTCAATTGTTACATTTGCTCGGCGGTTTTCACAGCTCCCGGAGGCTTACTCAATCACATGGCAGAGCATGGAGCCCATTCGCGGCCCTATGATTGTAGCTTGTGTCCAGAGAAATTCTACTTCCGGGCGGAGCTGGAGCATCATCAGAGGAGCCACGAGCTGAGGCCACAGGCCACGAGGCCACCCATGCCCAAGGTGGAGGCACCCTCCATTAGGAATAGTTCGCCCATTTGCGAGAGTCCTCCCTCAAGGAGTCGCAGTCCCACAATTAATGTCAAGCAGGAGCTCTACGAAACGGACACTGTGGAGTCGGGAGCAGGTGAAGATGAGCCAGAGGAGAATCCACAAGAAGATGAGGAGTACATAGAAGTAGAGCAGGTGCCGCAGGAGACACGAACCAGTGAGATGGCTTCGCAAATGGAAAGGTCCACGAGTAGCGCCTAA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATKEITNSDMYSTHTSSSYSPSISDGTMTPNSHHLPGALTSAAASGQEDHHHSDGKLNGGTDGEELAKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGAGGGAGAGGAGSKFDKLTGEGIKARGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRLDFPKRSRSSHVGGSNTTATATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQQHQHAAKTPTAPESEGFQLSCEYCTMKFGNIAGLFQHMRSTHLDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERETTRAAEEDLPTDLSSNKRRSQTPTNNQQLQSQQLAPPTAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQMVCPHCGLSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSDHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPAIGATPSAPANPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGGVKDKEQQRGSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGGAGGGAASGAGSGSGGGSGAAPPSNNKFYSPLQVDTNALKAQASPHPALMYGLSQRYLMEMYAAKSTSPAGGNEGNPQPPQATAPPSAPPSAAPATATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGATLPLACICCRQTLHSEFELSLHAKFHTKSASSGGSLQEPVCALCLEPLPDVPVEGPAKLCEKCCRKHNLNGKRGKPSDPQLQAPPSAGGAGAGAAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMAEHGAHSRPYDCSLCPEKFYFRAELEHHQRSHELRPQATRPPMPKVEAPSIRNSSPICESPPSRSRSPTINVKQELYETDTVESGAGEDEPEENPQEDEEYIEVEQVPQETRTSEMASQMERSTSSA