Dasa002927.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila asahinai
Gene Symbol
MBD2
Assembly
GCA_008042795.1
Location
VNJZ01009592.1:22562-24205[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.4e-22 1.4e-18 66.5 0.0 1 74 8 98 8 101 0.94
2 2 2.6e-06 0.011 15.6 0.0 27 76 201 261 183 262 0.91

Sequence Information

Coding Sequence
ATGCAAAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCGAAAGGATGGCAGCGCGAGGAGGTCCGCAAGTCCGGCAGCAGCTCCAATAGCAACGCCAGCGCacccaacaccaacaccaacaccaccaccgccagcaacaacaacaacaacaacaaggtgGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAGAGCAAGCCGCAGCTGGCGCGCCAATTGGGCGGCGAGTCCTTCGACATCGCCAGCTTTGATTTCCAGTCCGGcaagatgcagcagcagcagcagcagccacaccaCCAAAGGGCGCTGCCCTCCCCCTCCATTTCGCTGTACCGCTGCAGCGCCATGCCGCTGCCGTTGacgggcggcggtggcagtggCGGCCACGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTGGCCCGCTCGCAGCTGGGCAGCCAGGTGGGCAGTGCGGGATCTGGCTCGGGAACAgtagccacagcagcagcggcggcggcagcagccgcctcctcctcctccacatCCTCCTCGCCCACGGCAGCCaaccgccagcagcagcagattgaACTCAGCCGGGCGCTGCGCACAGATGTCTCCCTGGTGCCACCCATCCGACAGACTGCCTCAATCTTCAAGCAACCGGTGACGGCGATTCGCAACCACAGCCAGGACCCGGCGAAGGTGAAACACGACGCCAAGCATGGCACTCAGGAGAAGCCCAAGCAGTTGTTCTGGGAGAAGCGACTGGAGCGACTGCGCGCCTGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAAACCATACGCACTGTCGGCCCCAATGTCAATGAACAGACCGTCCTGCAATCGGTGGCCACCGCCCTGCACATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGACTTGACCAAGAATGCGATGGCATTCATGAATCCCGAACAGCCGCTCATGCATGCCGTGATCATCTCTGAGGACGATATACGAAAGCAGGAGGATCGGGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCCCTCAAAACATGA
Protein Sequence
MQNPSVTIERKRVDCSVLPKGWQREEVRKSGSSSNSNASAPNTNTNTTTASNNNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDIASFDFQSGKMQQQQQQPHHQRALPSPSISLYRCSAMPLPLTGGGGSGGHGSAANALKRKLARSQLGSQVGSAGSGSGTVATAAAAAAAAASSSSTSSSPTAANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPAKVKHDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT