Basic Information

Gene Symbol
MBD2
Assembly
GCA_016746395.1
Location
NC:16530338-16532143[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.9e-20 3e-16 58.4 0.0 1 58 9 87 9 105 0.91
2 2 1.3e-07 0.00043 19.5 0.0 27 76 181 241 129 242 0.89

Sequence Information

Coding Sequence
ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCAAAGGGATGGCAGCGCGACGAAGTCCGAAAGTCCGGCAGCAGCGCCAATAGtaacgccagcagcaacaacaacagcagcagtgccacagccagcagcaacaacaacaataacaaggtGGATGTTTTCTACTACAGCAGTCCCACAGGAAAAAGGGCGGAGGGAAAGCCGCAGGACATTGCAATCCCTGATTTCCAGTCTGGCAAGATGCCACACCGCGCCCTGCCCTCGCCCTCCATTTCACTGTACCGCTGCAGCGCCATGCCGCTGCCCATAGCGAGCGGGGGCGGTAATGGGGCCACCAGCGGATCAGCGTCCAATGCCCTCAAGCGCAAGTTCGCCCGGAGTCAAGGAGGcaatgctgcagcagcagcaggaggagctgctccCCCGGCAGCGGCTGCCTcgtcagcagcaacagcagcatcagcatctgcTTCACCATCAACGGCCAatcgccagcagcaacagatcGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCGCCCATTCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGTGATTCGCAACCACAAACAGGATCCCGCCAAGGCGAAGAATGATCCCAAGCATGGCACTCGGGAGAAGCCGAAACAGCTGTTCTGGGAGAAGCGACTGGAACGACTACGCGCCTGCCACGACAGCGGCGAGGAGCTAGACGACATCTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACGGCCCTGCATATGCTCAACGCCGGCGTACACGGCCAGAGTTCTACGAAGGCTGATTTGACCAAGAATGCCATGGCGTTTATGAATCCTGAACAGCCGCTCATGCACGCGGTGATCATTTCGGAGGACGACATACGCAAACAGGAGGATAGGGTCGGAGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANSNASSNNNSSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDIAIPDFQSGKMPHRALPSPSISLYRCSAMPLPIASGGGNGATSGSASNALKRKFARSQGGNAAAAAGGAAPPAAAASSAATAASASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNDPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480158;
90% Identity
iTF_00548058;
80% Identity
-