Dtan012769.1
Basic Information
- Insect
- Drosophila tani
- Gene Symbol
- MBD2
- Assembly
- GCA_008042535.1
- Location
- VNJO01003685.1:60543-62195[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.6e-22 1.4e-18 66.5 0.0 1 74 8 98 8 101 0.94 2 2 3.5e-06 0.011 15.6 0.0 27 76 197 257 179 258 0.91
Sequence Information
- Coding Sequence
- ATGCAAAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCGAAAGGATGGCAGCGCGAGGAGGTCCGCAAGTCCGGCAGCAGCTCCAATAGCAACGCCAGCGCacccaacaccaacaccaccaccaccaccgccagcaacaacaacaacaacaacaaggtgGATGTTTTCTACTACAGTCCCACAGGAAAGCGGGTCGAGAGCAAGCCGCAGCTGGCGCGCCAATTGGGCGGCGAGTCCTTCGACATTGCCAGCTTTGATTTCCAGTCCGGcaagatgcagcagcagcagcagcaacaccaccaAAGGGCGCTGCCCTCCCCCTCCATTTCACTGTACCGCTGCAGCGCCATGCCGCTGCCGTtgacaggcggcggcggtggcagtggcGGCCACGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTGGCCCGCTCGCAGCTGGGCAATGCGGGATCTGGCTCGGGATcagtagcaacagcagcggcggcagcagcagcagccgcctccgcctcctcatcctcctcgccCACGGCAGCAGCCaaccgccagcagcagcagatagAACTCAGCCGGGCGCTGCGCACAGATGTCTCCCTGGTGCCACCCATCCGACAGACTGCCTCGATCTTTAAGCAACCGGTGACGGCGATTCGCAACCACAGCCAGGACCCGGCGAAGGTAAAACACGATGCCAAGCATGGCACTCAGGAGAAGCCCAAGCAGTTGTTCTGGGAGAAGCGACTGGAGCGACTGCGTGCCTGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAAACCATACGCACTGTTGGCCCCAATGTCAATGAACAGACCGTCCTGCAATCGGTGGCCACCGCCCTGCATATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGACTTGACCAAGAATGCCATGGCATTCATGAATCCCGAACAGCCGCTCATGCATGCCGTGATCATCTCTGAGGATGATATACGAAAGCAGGAGGATCGGGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCCCTCAAAACATGA
- Protein Sequence
- MQNPSVTIERKRVDCSVLPKGWQREEVRKSGSSSNSNASAPNTNTTTTTASNNNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDIASFDFQSGKMQQQQQQHHQRALPSPSISLYRCSAMPLPLTGGGGGSGGHGSAANALKRKLARSQLGNAGSGSGSVATAAAAAAAAASASSSSSPTAAANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPAKVKHDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00480158;
- 90% Identity
- iTF_00490074;
- 80% Identity
- -