Basic Information

Gene Symbol
MBD2
Assembly
GCA_018153835.1
Location
NW:645914-647650[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.4e-21 1.8e-17 62.4 0.0 1 58 9 85 9 104 0.89
2 2 1.1e-06 0.0032 16.7 0.0 26 76 174 235 127 236 0.87

Sequence Information

Coding Sequence
ATGCAAATGAACCCGAGCGTTACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCAAAAGGATGGCAGCGCGAGGAGGTCCGCAAATCGGGCAATAGCTCCAATAGCAacgccagcagcaacaacaacagcagcaccaccacagccagcaacaacaacaataacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAAAGGGCGGAGGGAAAGCCGCAGGATATTACAATCCCTGATTTCCAATCCGGAAAGATGCAACAACGGGCCCTGCCCTCGCCATCTATTTCACTGTATCGCTGCAGTGCCATGCCGCTACCCTTGACCAGTGGCGGTGGAAATGGTTCCACTACCGGATCGCAGGCCAATGCTCTCAAGCGCAAGTTTGCCAGGAGCCAAGGAGGCACTGCTACAGCAGGAGGTGCTGCTCCTCCGGCCGTGGTCCCGTTATCAACAGCTGCAGCCTCATCTGCATCACCATCAACGACCAAtcgccagcagcaacagaacgAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCGCCAATCCGACAGACTGCATCGATCTTCAAGCAACCGGTGACGGCAATTCGCAATCACAGTCAGGATCCTGCCAAAGTGAAGCATGATACCAAGCATGGCACTCGAGAGAAGCCCAAACAGCTCTTCTGGGAGAAGCGGCTGGAAAGACTCCGCGCCTGCCACGACAGCGGGGAGGAGCTTGACGACATCTCACTGCCCAAGACCATACGCACCGTTGGCCCGAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCTACGGCACTACATATGCTCAATGCCGGCGTCCACGGCCAGAGCTCCACGAAGGCTGACTTGACCAAGAATGCGATGGCATTCATGAATCCCGAACAGCCGCTAATGCACGCGGTAATCATCTCAGAGGACGACATACGCAAGCAGGAGGACCGGGTCGGTGTGGCGCGGCGAAAGCTGCAGGACGCGCTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQREEVRKSGNSSNSNASSNNNSSTTTASNNNNNKVDVFYYSPTGKRAEGKPQDITIPDFQSGKMQQRALPSPSISLYRCSAMPLPLTSGGGNGSTTGSQANALKRKFARSQGGTATAGGAAPPAVVPLSTAAASSASPSTTNRQQQQNELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPAKVKHDTKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480158;
90% Identity
iTF_00548058;
80% Identity
-