Basic Information

Gene Symbol
MBD2
Assembly
GCA_008042735.1
Location
VNKB01003245.1:12548-14170[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.7e-21 8.4e-18 63.8 0.0 1 74 8 93 8 96 0.92
2 2 3.1e-06 0.0097 15.6 0.0 27 76 192 252 174 253 0.92

Sequence Information

Coding Sequence
ATGCAGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGCCCTGCCGAAAGGATGGCAGCGTGAAGAGGTCCGCAAGTCCGGCAGCGGCTCCAATAGCAACGCCAGCgccaccaacaccaccaccgccagcaacaacaataacaacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAGAGCAAGCCGCAGTTGGCGCGCCAATTGGGCGGCGAGTCCTTTGACCTCGCCAGCTTTGATTTCCAGTCCGGcaagatgcagcagcagcagcagcagcaacatcaccagCGGGCGCTGCCGTCGCCCTCCATTTCGCTGTACCGCTGCAGCGCCATGCCGCTGCCTTTGAcgggcggcggtggcagcggTGGCCACGGATCGGCGGCCAATACCCTCAAGCGCAAGTTGGCCCGCTCGCAGCTGGGCAGCCAGGCGGGCAGTGGGGGATCTGGCTCGGGATCAGCTCCAATAGCAGCACCggctgccgcagcagcagccgcctcgTCCTCGCCCACAGCAGCCaaccgccagcagcagcagattgaACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCACCTATCCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGCGATTCGAAACCACAGCCAGGAGCCCGAAAAGGTGAAACCCGACGCCAAGCATGGCACTCAGGAGAAGCCCAAACAGTTGTTTTGGGAGAAGCGACTGGAGCGACTGCGCGCCTGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAGACCATACGCACTGTTGGTCCCAATGTCAATGAACAGACCGTCCTCCAATCGGTGGCCACCGCTCTGCACATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGATCTGACCAAAAATGCGATGGCATTCATGAATCCCGAACAGCCGCTCATGCATGCGGTGATCATCTCCGAGGATGACATACGGAAGCAGGAGGATCGGGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
Protein Sequence
MQNPSVTIERKRVDCSALPKGWQREEVRKSGSGSNSNASATNTTTASNNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDLASFDFQSGKMQQQQQQQHHQRALPSPSISLYRCSAMPLPLTGGGGSGGHGSAANTLKRKLARSQLGSQAGSGGSGSGSAPIAAPAAAAAAASSSPTAANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQEPEKVKPDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480158;
90% Identity
iTF_00490074;
80% Identity
-