Dboq015114.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila bocqueti
Gene Symbol
MBD2
Assembly
GCA_018151655.1
Location
JAECXF010000001.1:20107889-20109522[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.1e-22 9.3e-19 66.8 0.0 1 74 8 96 8 99 0.94
2 2 2e-06 0.0089 15.6 0.0 27 76 195 255 176 256 0.92

Sequence Information

Coding Sequence
ATGCAGAACCCTAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCGAAAGGATGGCAGCGCGAAGAGGTCCGCAAGTCCGGCAGCAGCTCCAATAGCAACGCCAGCGCCACCAACACCAACACCACCACCGCCAGCAACAACAACAACAATAACAAGGTGGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAGAGCAAGCCGCAGTTGGCGCGCCAATTGGGCGGCGAGTCCTTTGACATCGCCAGCTTTGATTTCCAGTCCGGCAAGATGCAGCAGCAGCAGCAACAACCACACCACCAGCGGGCGCTGCCCTCCCCTTCCATTTCGCTTTACCGCTGCAGCGCCATGCCGCTGCCGCTGACGGGCGGCGGTGGCAGCGGTGGCCACGGATCTGCGGCAAACGCCCTCAAGCGCAAGTTGGCCCGCTCGCAGCTGGGCAGCCAGGCCAATGCGGGATCTGGCTCGGGATTAGCTCCAATAACAGCGGCGGCGGCAGCAGCAGCCGCCTCCTCCTCCTCCTCGCCCACGGCAGCCAACCGCCAGCAGCAGCAGATTGAACTCAGCCGGGCGCTTCGCACAGACGTCTCCCTGGTGCCACCCATCCGACAGACTGCCTCGATCTTCAAGCAACCCGTGACGGCTATTCGAAACCACAGCCAGGACCCTGCGAAGGCGAAACCAGACGCCAAGCATGGCACTCAGGAGAAGCCCAAACAGTTGTTCTGGGAGAAACGATTGGAGCGACTGCGCGCATGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAAACCATACGCACTGTTGGCCCCAATGTCAACGAACAGACCGTCCTGCAATCGGTGGCCACAGCTCTGCACATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGACTTGACCAAGAATGCGATGGCGTTCATGAATCCCGAACAGCCGCTGATGCATGCGGTGATCATCTCCGAAGACGATATACGGAAGCAGGAGGATCGTGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTTAAGACATGA
Protein Sequence
MQNPSVTIERKRVDCSVLPKGWQREEVRKSGSSSNSNASATNTNTTTASNNNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDIASFDFQSGKMQQQQQQPHHQRALPSPSISLYRCSAMPLPLTGGGGSGGHGSAANALKRKLARSQLGSQANAGSGSGLAPITAAAAAAAASSSSSPTAANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPAKAKPDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT