Basic Information

Gene Symbol
MBD2
Assembly
GCA_008042635.1
Location
VNJV01014296.1:27974-29560[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.8e-22 2.3e-18 66.0 0.0 1 74 8 94 8 97 0.94
2 2 1.9e-06 0.012 15.7 0.0 27 76 187 247 167 248 0.92

Sequence Information

Coding Sequence
ATGCAGAACCCCAGCGTCACAATCGAGCGCAAACGCGTAGACTGCAGTGCCCTGCCGAAAGGATGGCAGCGCGAAGAGGTTCGCAAGTCCGGCAGCAGCTCCAATAGCAACGCCAGCGccaccaacaccaccaccgccagcaacaacaacaacaataacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAAAGCAAGCCGCAGTTGGCGCGCCAATTGGGCGGCGAGTCCTTTGACATCGCCAGCTTTGATTTCCAGTCCGGcaagatgcagcagcagcaacaaccacaCCACCAGCGggcgctgccgccgccttcCATTTCGCTGTACCGCTGCAGCGCCATGCCGCTGCCGTTGACGGGCGGCGGTGGCCACGGATCTGCGGCCAACGCCCTCAAGCGCAAGTTGGCCCGCTCGCAGCTGGGCAGCCAGGCCAATGTGGGATCTGGCTCGGGATCAGCTCCAAtaacagcggcggcagcagcagccgccagtTCCTCATCGCCCACCACAGCCAaccgtcagcagcagcagattgAACTCAGCCGGGCCCTTCGCACAGACGTCTCCCTGGTGCCACCCATCCGACAGACTGCCTCGATCTTTAAGCAACCCGTAACGGCTATTCGAAACCACAGCCAGGACCCTGGGAAGGCGAAACCAGACGCCAAGCATGGCACTCAGGAGAAGCCCAAACAGTTGTTCTGGGAGAAACGACTGGAGCGACTGCGCGCATGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAAACCATACGCACTGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAATCGGTGGCCACAGCTCTGCACATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGACTTGACCAAGAATGCGATGGCGTTCATGAATCCCGAACAGCCGCTCATGCATGCGGTTATCATCTCCGAAGACGATATAAGGAAGCAGGAGGATCGTGTTGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTTAAGACATGA
Protein Sequence
MQNPSVTIERKRVDCSALPKGWQREEVRKSGSSSNSNASATNTTTASNNNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDIASFDFQSGKMQQQQQPHHQRALPPPSISLYRCSAMPLPLTGGGGHGSAANALKRKLARSQLGSQANVGSGSGSAPITAAAAAAASSSSPTTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPGKAKPDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480158;
90% Identity
iTF_00490074;
80% Identity
-