Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8.9e-20 3e-16 58.4 0.0 1 58 9 87 9 105 0.91

2 2 1e-07 0.00035 19.7 0.0 27 76 181 241 128 242 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8.9e-20	3e-16	58.4	0.0	1	58	9	87	9	105	0.91
2	2	1e-07	0.00035	19.7	0.0	27	76	181	241	128	242	0.83

Coding Sequence: ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCAAAGGGTTGGCAGCGCGACGAGGTCCGAAAGTCCGGCAGCAGCGCCAATAGCaacgccagcagcaacaacaacagcagcagtgccacagccagcagcaacaacaacaataacaaggtGGATGTTTTCTACTACAGCAGTCCCACAGGAAAAAGGGCGGAGGGAAAGCCGCAGGACATTGCAATCCCTGATTTCCAGTCTGGCAAGATGCCACACCGCGCCCTGCCCTCGCCCTCCATTTCACTGTACCGCTGCAGCGCCATGCCGCTGCCCATAGCGAGCGGGGGCGGTAATGGGGCCACCAGCGGATCAGCGGCCAATGCCCTCAAGCGCAAATTCGCTCGGAGTCAAGGAGCCagtgctgcagcagcagcaggaggagctgcTCCCCCGGCAGCGGCCGCCTcgtcagcagcaacagcagcatcagcatctGCTTCACCATCAACGGCCAatcgccagcagcaacagatcGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTACCGCCCATTCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGTGATTCGCAACCACAAGCAGGATCCCGCCAAAGCGAAGAATGATCCCAAGCATGGCACCCGGGAGAAGCCGAAACAGCTGTTCTGGGAGAAGCGACTGGAACGACTACGCGCCTGCCACGACAGCGGCGAGGAGCTAGACGACATTTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACGGCGCTGCATATGCTCAACGCCGGTGTACACGGCCAGAGTTCTACGAAGGCTGATTTGACCAAGAATGCCATGGCGTTTATGAATCCTGAACAGCCGCTCATGCACGCGGTGATCATTTCGGAGGACGACATACGCAAACAGGAGGATAGGGTTGGAGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
Protein Sequence: MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANSNASSNNNSSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDIAIPDFQSGKMPHRALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGASAAAAAGGAAPPAAAASSAATAASASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNDPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2