Dsup008933.1
Basic Information
- Insect
- Drosophila subpulchrella
- Gene Symbol
- MBD2
- Assembly
- GCA_014743375.2
- Location
- NC:14755452-14757279[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.5e-19 1.6e-15 56.2 0.0 1 49 9 80 9 101 0.94 2 2 1.2e-06 0.0034 16.7 0.0 27 76 181 241 132 242 0.86
Sequence Information
- Coding Sequence
- ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCCAAAGGATGGCAGCGCGACGAGGTCCGCAAGTCCGGCAGCAGCTCCAATAGCaacgccagcagcaacaacaacaacaacagcagcagcagtgccacagccagcagcaacaacaacaataacaaggTGGATGTTTTCTACTACAGTCCCACAGGAAAAAGGGCGGAGGGAAAGCCGCAGCAGGACCTTGTTATCCCCGATTTCCAAACCGGCAAGATGCAGCAACGGGCCCTGCCCTCGCCATCCATATCGCTGTACCGCTGCAGCGCCATGCCGCTCCCGCTGACCAGTGGCGGCGGAAATGGGGCCACCACCGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTCGCCCGCAGCCAAGGAGgcactgcagcagcaacagcagcaggaggaggagctgcTCCTCAGGCGTTGACTGCCTCATcagcagcggcggcagcaTCATCTGCGGTCAAtcgccagcagcaacagattGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCTTGGTGCCTCCCATCCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGCGATTCGCAACCATACCCAGGATCCCGCCAAGGTGAAGCACGACGCCAAGCATGGCACTCGGGAGAAGCCCAAGCAGCTGTTTTGGGAAAAGCGGCTGGAACGACTGCGCGCCTGCCACGACAGCGGCGAGGAGCTGGATGATATCTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAATGAACAGACCGTCCTCCAGTCTGTGGCCACGGCGCTGCACATGCTCAATGCCGGTGTCCACGGCCAGAGTTCCACGAAGGCTGACTTGACCAAGAATGCCATGGCATTCATGAATCCCGAACAGCCCCTCATGCACGCGGTCATCATCTCCGAGGACGACATTCGTAAGCAGGAGGATCGGGTCGGTGTGGCGCGGCGGAAGCTGCAGGATGCACTCAAGACATGA
- Protein Sequence
- MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSSNSNASSNNNNNSSSSATASSNNNNNKVDVFYYSPTGKRAEGKPQQDLVIPDFQTGKMQQRALPSPSISLYRCSAMPLPLTSGGGNGATTGSAANALKRKFARSQGGTAAATAAGGGAAPQALTASSAAAAASSAVNRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHTQDPAKVKHDAKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00480158;
- 90% Identity
- iTF_00548058;
- 80% Identity
- -