Dkik005757.1
Basic Information
- Insect
- Drosophila kikkawai
- Gene Symbol
- MBD2
- Assembly
- GCA_018152535.1
- Location
- NW:26507061-26509035[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.8e-22 1.1e-18 66.3 0.0 1 74 8 92 8 95 0.93 2 2 2.6e-06 0.0074 15.6 0.0 27 76 192 252 174 253 0.92
Sequence Information
- Coding Sequence
- ATGCAGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGCCCTGCCGAAAGGATGGCAGCGTGAAGAGGTCCGCAAGTCCGGCAGCAGCTCCAATAGCAACGCCAGCGCTAccaacaccaccaccgccagcaacaacaataacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAGAGCAAGCCGCAGTTGGCGCGCCAATTGGGCGGCGAGTCCTTTGACCTCGCCAGCTTTGATTTCCAGTCCGGcaagatgcagcagcagcagcagcaacatcaccaGCGGGCGCTGCCGTCGCCCTCCATTTCGCTGTACCGCTGCAGCGCCATGCCGTTGCCTTTGACGGGCGGCGGTGGCAGCGGTGGCCACGGATCGGCGGCCAATACCCTCAAGCGCAAGTTGGCCCGTTCGCAGCTGGGCAGCCAGGCGGGCAGTGGGGGATCTGGCTCGGGATCAGCTCCAatagcagcagcggcggccgcagcagcagccgtctcctcctcgtcctcgccCACGGCAACCaaccgccagcagcagcagattgAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCACCCATCCGACAGACTGCCTCGATATTCAAGCAACCGGTGACGGCGATTCGAAACCACAGCCAGGATCCCGGAAAGGTGAAACCGGACGCCAAGCATGGCACTCAGGAGAAGCCCAAACAGTTGTTTTGGGAGAAGCGACTGGAGCGACTGCGCGCCTGCCACGACAATGGCGAGGAGCTCGATGACATCTCACTGCCCAAGACCATACGCACTGTTGGTCCCAATGTCAATGAACAGACCGTCCTCCAATCGGTGGCCACCGCTCTGCACATGCTCAATGCCGGCGTGCACGGCCAGAGTTCGACAAAGGCTGATCTGACCAAAAATGCGATGGCATTCATGAATCCCGAACAGCCGCTCATGCATGCGGTGATCATCTCCGAGGACGACATACGGAAGCAGGAGGATCGTGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
- Protein Sequence
- MQNPSVTIERKRVDCSALPKGWQREEVRKSGSSSNSNASATNTTTASNNNNKVDVFYYSPTGKRVESKPQLARQLGGESFDLASFDFQSGKMQQQQQQHHQRALPSPSISLYRCSAMPLPLTGGGGSGGHGSAANTLKRKLARSQLGSQAGSGGSGSGSAPIAAAAAAAAAVSSSSSPTATNRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPGKVKPDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00480158;
- 90% Identity
- iTF_00490074;
- 80% Identity
- -