Basic Information

Gene Symbol
Mbd3
Assembly
GCA_905340225.1
Location
HG996501.1:7119285-7122587[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5e-28 2.2e-24 85.2 0.1 1 72 8 74 8 78 0.95
2 2 0.00026 1.2 9.1 0.0 29 74 96 149 81 152 0.86

Sequence Information

Coding Sequence
ATGAGTACTATGAATATATCTATAGAAAAAAAAAGATCGGACTGCCCTGCCTTACCCAAGGGTTGGCAGAGGGAAGAAGTTTTAAGGAAAACGGGGCTATCTGCCGGCAAAGTTGATGTTTACTATTACAGCCCAACAGGTAAAAAGTTTCGCAGTAAAGCTGAGCTAGTTCGTTATCTGGGTGATAGTATGGACCTGTCGTGTTTCGACTTTCAGCAAGGTCAGATAAACACAATGCTGCTGTGCAAGGCCAAGAAAGCACGAGCGCAGTTTGACTACAGGGGCGTCCGTTCTGATGCGTCTTTGGTACCGCCAATACGTCAGACAGCGTCAATTTTTAAGCAACCTGTAACTGTGTACAAAACACAGGAAAGCAAAGTGAAAACTGATCTGAAACATGGCACGCAGGAGAAACCTAAACAATTGTTTTGGGAAAAGAGATTGGAAGGTTTGACGGCGTGTGACGCAGACGGAGTTAGAGGTACTACTTCCTTACCAAAATACATCAAGCCCTTGGGCCCATACAACTCTGATGCCACGATCATTCAGTCGCTAGCAACAGCTCTTCATGTATCTTCACAGCCCATTACTGGTCAAACTGGTTCCAAGCAATCTATTTTAGAGAACCCAGGAGTTTTTTTAAACCCTGAACAGCCGCTCATCGCGGCTGTGACAATAACTAAGGATGACGTCAGGCGCCAGGAGGAACGCGTGCGGCGCGCGCGTCAGAGACTGCAGCAGGTCTTGGCGGTGGCATAG
Protein Sequence
MSTMNISIEKKRSDCPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKAELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDADGVRGTTSLPKYIKPLGPYNSDATIIQSLATALHVSSQPITGQTGSKQSILENPGVFLNPEQPLIAAVTITKDDVRRQEERVRRARQRLQQVLAVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090793;
90% Identity
iTF_00654305; iTF_00622850; iTF_01192738; iTF_01387618; iTF_01386724; iTF_01388488; iTF_01385771; iTF_01341296; iTF_00007107; iTF_00634499; iTF_00761700; iTF_01437067; iTF_01251756; iTF_01083348; iTF_01415860; iTF_01416800; iTF_00622019; iTF_01073635; iTF_00834651; iTF_01425953; iTF_00042657; iTF_00786018; iTF_01093122; iTF_01490146; iTF_00043523; iTF_00235875; iTF_01533955; iTF_00907908; iTF_00256933; iTF_01176197; iTF_00041798; iTF_00049926; iTF_00124294; iTF_00236646; iTF_00345830; iTF_01487718; iTF_00123400; iTF_01062824; iTF_00018185; iTF_00036745; iTF_00114121; iTF_00449129; iTF_01076522; iTF_00709259; iTF_01180331; iTF_00038796; iTF_00375244; iTF_00771949; iTF_01094061; iTF_01153997; iTF_00144590; iTF_00300238; iTF_01064686; iTF_01331598; iTF_00017359; iTF_00055439; iTF_00726383; iTF_00831247; iTF_00973807; iTF_00783504; iTF_00850768; iTF_00851824; iTF_01230608; iTF_00364049; iTF_01538769; iTF_01312242; iTF_01173299; iTF_01316371; iTF_00122420; iTF_00185332; iTF_00302132; iTF_00390388; iTF_00446164; iTF_00667508; iTF_00255925; iTF_01377493; iTF_00407606; iTF_01117238; iTF_01179510; iTF_00186199; iTF_00928727; iTF_01363127; iTF_00147480; iTF_00818360; iTF_00121465; iTF_01061913; iTF_00666554; iTF_01221594; iTF_00039835; iTF_00821851; iTF_00374140; iTF_00907068; iTF_01285564; iTF_00177149; iTF_00701085; iTF_00736637; iTF_01094941; iTF_00327102; iTF_00784414; iTF_00237599; iTF_01118335; iTF_01342239; iTF_00425408; iTF_00906176; iTF_00952736; iTF_01317312; iTF_00195184; iTF_00837554; iTF_01026212; iTF_01340135; iTF_00785226; iTF_01029290; iTF_00951858; iTF_01027349; iTF_00745720; iTF_01028316; iTF_01031166; iTF_00888288; iTF_00072165; iTF_00858566; iTF_00859489; iTF_01429957; iTF_00820104; iTF_01010377; iTF_00290730; iTF_01358890; iTF_00819185; iTF_00341336; iTF_00787673; iTF_00063612; iTF_00072836; iTF_00674311; iTF_00705031; iTF_00702920; iTF_00703985; iTF_00111688; iTF_00648008; iTF_00833023; iTF_01463272; iTF_00462409; iTF_00323530; iTF_01090793; iTF_00432219; iTF_00810091; iTF_00001196; iTF_00361644; iTF_00377126; iTF_01528311; iTF_01085260; iTF_00301197; iTF_00711886; iTF_00037839; iTF_01533072; iTF_00120532; iTF_01527252; iTF_01439958; iTF_00447164; iTF_01526044; iTF_01441117; iTF_01361645; iTF_01362448; iTF_00660335; iTF_00074529; iTF_01245955; iTF_00156260; iTF_00208900; iTF_00288068; iTF_00772900; iTF_01193606; iTF_00657223; iTF_00076552; iTF_00010089; iTF_00148489; iTF_00149417; iTF_00342218; iTF_01125484; iTF_00412527; iTF_00680560; iTF_01464178; iTF_00409300; iTF_00960948; iTF_01134807; iTF_00411480; iTF_00006297; iTF_00325401; iTF_01359772; iTF_01503900; iTF_00410301; iTF_01135773; iTF_00752095; iTF_01071647; iTF_01222496; iTF_01075460; iTF_00706979; iTF_00908867; iTF_00794628; iTF_00931428; iTF_00281349; iTF_00157223; iTF_00636423; iTF_00637672; iTF_00441513; iTF_01436107; iTF_00823916; iTF_00282414; iTF_00404943; iTF_01197745; iTF_01152179; iTF_00823060; iTF_01491957; iTF_00869654; iTF_01332728; iTF_01166715; iTF_00932572; iTF_01360637; iTF_01502109; iTF_00197381; iTF_01115718; iTF_01495792; iTF_01494325; iTF_01130046; iTF_01544903; iTF_01545769; iTF_01542987; iTF_01546669; iTF_01543954; iTF_01144552; iTF_00677645; iTF_00795727; iTF_01438951; iTF_01438001; iTF_01153042; iTF_00887415; iTF_00166936; iTF_00970427; iTF_01082459; iTF_00971390; iTF_01140214; iTF_01156470; iTF_01158979; iTF_01337766; iTF_01155211; iTF_01157805; iTF_00114967; iTF_00771101; iTF_00913626; iTF_00032930; iTF_00926626; iTF_00207011; iTF_00206089; iTF_00044522; iTF_00826986; iTF_01209291; iTF_00143084; iTF_00250478; iTF_01208207; iTF_01204914; iTF_00125139; iTF_01205717; iTF_00249720; iTF_00895960; iTF_00942841; iTF_01203257; iTF_00180509; iTF_00825757; iTF_00033823; iTF_00935744; iTF_01141691; iTF_01148828; iTF_01140936; iTF_00403826; iTF_00383681; iTF_00164386; iTF_00925735; iTF_01334919; iTF_00405928; iTF_00429033; iTF_01217513; iTF_01279273; iTF_00650027; iTF_01172396; iTF_00744654; iTF_00933775; iTF_00428144; iTF_00433170; iTF_00710226; iTF_01248147; iTF_00288885; iTF_01178583; iTF_01280311; iTF_01020313; iTF_00261882; iTF_00786810; iTF_00649115; iTF_00786811; iTF_00934779; iTF_00027772; iTF_00711037; iTF_00635424; iTF_01021248; iTF_01202482; iTF_01206565; iTF_00699187; iTF_00706034; iTF_00878868; iTF_00923700; iTF_00161558; iTF_00172982; iTF_00273623; iTF_00809162; iTF_00274451; iTF_00685463; iTF_01063784; iTF_01204055; iTF_00450137; iTF_00663097; iTF_00662241; iTF_00909729; iTF_00267202; iTF_01182915; iTF_00856646; iTF_00638663; iTF_00811047; iTF_01429066; iTF_00700141; iTF_01219791; iTF_00321616; iTF_00661299; iTF_01161395; iTF_01335955; iTF_00697365; iTF_00702006; iTF_00026871; iTF_01509625; iTF_01170618; iTF_01529210; iTF_00686363; iTF_00737499; iTF_00119616; iTF_00318112; iTF_01171488; iTF_00806746; iTF_01124608; iTF_00876188; iTF_00874480; iTF_00875324; iTF_00947910; iTF_00356218; iTF_00355175; iTF_00077501; iTF_00150568; iTF_01260125; iTF_01247006; iTF_01338782; iTF_01119357; iTF_00207935; iTF_00790283; iTF_00698335; iTF_00696490; iTF_00289632; iTF_00827968; iTF_01084288; iTF_01030260; iTF_01564672;
80% Identity
iTF_00001196;