Aeph009288.1
Basic Information
- Insect
- Acentria ephemerella
- Gene Symbol
- Mbd2
- Assembly
- GCA_943193655.1
- Location
- CALPDL010000053.1:1034687-1040653[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.4e-28 9.2e-25 86.3 0.1 2 73 6 72 5 76 0.94 2 2 0.0011 3.1 7.7 0.1 29 73 93 145 72 148 0.81
Sequence Information
- Coding Sequence
- ATGAATATTTCAATAGAGAAAAAAAGAATTGATTGTACGGCTTTACCAAAAGGCTGGCAAAGAGAAGAGGTTCTGAGAAAATCAGGTCTTTCTGCTGGCAAAGTTGATGTTTATTATTATAGCCCAACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTAGTTCGTTATCTCGGTGATAGTATGGACCTGTCGTGTTTCGACTTCCATCAAGGTCAAATAAACACTATGATGCTGTGCAAGGCCAAGAAAGCACGAGCGCAGTTCGATTACAGGGGTGTTCGGTCCGATGCATCACTTGTGCCGCCAATACGCCAAACTGCATCAATTTTCAAACAACCAGTTACTGTTTACAAGACCCAGGACAGTAAAGTGAAAACTGATTTGAAGCATGGCTCACAAGAAAAACCCAAACAACTATTTTGGGAGAAGAGATTAGAGGGTCTTTCAGCTTGTGATGCAAACGGTGTTATAGGAACTACATCATTACCTAAATACATAAAGCCTTTAGGTCCATATAACTCTGATGCAACCACCATCCAGTCTTTAGCTACTGCCCTTCATGTATCATCACAGCCTATCACAGGGCAAACTGGTGCCAAACAAGCGATATTAGAAAATCCGGGGGTGTTTTTAAATCCTGAGCAGCCATTGATCGCTGCTGTGACTATTAGTAAAGATGACGTTCGCCGTCAAGAGGACCGTGTGAAGCGCGCGCGCCTGCGGCTACAGGAGGCGCTCGTGGCCGCGTAG
- Protein Sequence
- MNISIEKKRIDCTALPKGWQREEVLRKSGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFHQGQINTMMLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQDSKVKTDLKHGSQEKPKQLFWEKRLEGLSACDANGVIGTTSLPKYIKPLGPYNSDATTIQSLATALHVSSQPITGQTGAKQAILENPGVFLNPEQPLIAAVTISKDDVRRQEDRVKRARLRLQEALVAA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01090793;
- 90% Identity
- iTF_00000356;
- 80% Identity
- -