Pfla012797.1
Basic Information
- Insect
- Perizoma flavofasciatum
- Gene Symbol
- Mbd3
- Assembly
- GCA_958496245.1
- Location
- OY292434.1:5270726-5274280[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 9.4e-28 3.7e-24 84.5 0.1 2 72 6 71 5 75 0.94 2 2 0.00037 1.5 8.9 0.0 29 73 93 145 78 147 0.86
Sequence Information
- Coding Sequence
- ATGAACATATcaattgaaaagaaaaaatctgAATGTCCTGCTTTGCCCAAAGGCTGGCAAAGAGaggaaattataagaaaaacggGTCTATCTGCTGGAAAAGTTGATGTTTATTACTACAGCCCTACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTTGTGCGTTATCTCGGTGATAGTATGGACCTGTCGTGTTTCGACTTCCAACAGGGTCAGATAAACACAATGCTGCTGTGCAAGGCCAAGAAAGCACGCGCGCAGTTCGATTACAGAGGGGTCCGATCTGACGCGTCCCTAGTGCCGCCTATTCGCCAAACCGCATCCATATTCAAGCAGCCGGTCACTGTGTACAAAACTCAGGAAAGCAAGGTCAAAACGGACTTGAAACATGGCACACAGGAGAAGCCCAAACAGCTGTTTTGGGAGAAGCGCTTAGAAGGAATTACAGCTTGTGACGCGAATGGTGTGTTAGCCACAACCTCACTCCCCAAGTACATCAAGCCCCTGGGTCCTTATAACTCTGATGCAACTACTATCCAGTCCCTGGCAACTACTCTGCATGTCTCCTCACAACCTATAACAGGGCAGCAAGGCTCAAAGCAAGCCATCATAGAGAACCCGGGGGTTTTCCTGAACCCTGAGCAGCCGTTGATCGCGGCCGTCACCATCACGAAAGACGACGTGCGCAAACAGGAGGAGCGCGTGTTGCGCGCGCGCAAGCGCTTGCAAGAGGCGCTCGCGGCCGCCTAG
- Protein Sequence
- MNISIEKKKSECPALPKGWQREEIIRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGITACDANGVLATTSLPKYIKPLGPYNSDATTIQSLATTLHVSSQPITGQQGSKQAIIENPGVFLNPEQPLIAAVTITKDDVRKQEERVLRARKRLQEALAAA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01090793;
- 90% Identity
- iTF_00000356;
- 80% Identity
- iTF_01170618;