Basic Information

Gene Symbol
MBD3
Assembly
GCA_905404095.1
Location
FR990058.1:8203647-8211238[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.9e-28 2.4e-24 85.9 0.1 1 72 5 71 5 76 0.95
2 2 0.00048 3.9 8.3 0.1 28 73 88 145 72 149 0.81

Sequence Information

Coding Sequence
ATGAATATATCAATCGAAAAGAAACGTTCTGACTGTGCAGCATTACCAAAAGGTTGGCAAAGAGAAGAAGTGATTAGAAAGACTGGCCTTTCTGCCGGAAAAGTAGATGTTTATTATTACAGCCCAACAGGTAAAAAGTTCCGCAGTAAGCCGGAACTAGTCCGTTATCTCGGTGATAGTATGGACCTATCATGTTTCGACTTCCAACAGGGTCAATTTAACACTATGATGCTGTGCAAGGCCAAGAAAGCTCGAGCGCAGTTTGATTACAGGGGTGTGCGTTCCGACGCTTCTCTCGTGCCTCCAATACGACAAACTGCATCTATTTTCAAGCAGCCTGTAACTGTATATAAAACACAAGAGAGCAAAGTGAAGACTGATCTCAAACATGGCTCACAGGAGAAGCCCAAACAACTTTTTTGGGAAAAGCGATTAGAAGGACTAACAGCCTGTGATGCAAACGGAGTCATTGGAAGTACTTCTCTCCCCAAGTACATCAAGTCTTTGGGCCCATACATATCAGATGCTACAACTATACAGTCTCTAGCAACTGCACTGCACGTATCATCACAACCTATTACAGGTCAGACAGGATCGAAGCAGACAATTTTGGAGAATCCTGGTGTTTTTTTAAACCCTGAGCAGCCGTTGATTGCGGCTATTACCATCACAAAGGAGGATGTCCGTAAGCAGGAGGAGCGAGTTAAGAAGGCCCGGCAAAGGCTGCAAAAAGCTCTGGTAGTTGCGTAG
Protein Sequence
MNISIEKKRSDCAALPKGWQREEVIRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQFNTMMLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGSQEKPKQLFWEKRLEGLTACDANGVIGSTSLPKYIKSLGPYISDATTIQSLATALHVSSQPITGQTGSKQTILENPGVFLNPEQPLIAAITITKEDVRKQEERVKKARQRLQKALVVA*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090793;
90% Identity
iTF_00000356;
80% Identity
-