Basic Information

Gene Symbol
Mbd3
Assembly
GCA_949315895.1
Location
OX438879.1:13231830-13242429[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7.5e-29 4.2e-25 88.4 0.0 1 72 5 71 5 75 0.95
2 2 0.00046 2.6 9.0 0.0 29 73 93 145 78 148 0.86

Sequence Information

Coding Sequence
atgaataTTTCAATAGAAAGGAAAAAAATGGATTGCCCAGCTTTGCCTAAAGGATGGCAAAGAGAAGAAGTATTAAGGAAAACGGGTCTTTCTGCTGGAAAAGTAGATGTGTATTATTACAGCCCAACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTAGTCCGTTATCTCGGTGATAGTATGGACTTGTCGTGTTTCGACTTTCATCAGGGTCAGATAAACACAATGCTACTATGTAAGGCCAAGAAAGCACGGGCGCAGTTCGATTACAGGGGTGTTCGTTCTGATGCATCTCTGGTGCCACCAATACGCCAAACTGCATCTATTTTCAAGCAACCAGTCACAGTATATAAAACCCAAGAGAGCAAGGTTAAAACCGATTTAAAACATGGTACACAAGAAAAACCCAAACAGTTGTTTTGGGAAAAAAGATTGGAAggATTGTCTGCGTGTGACGCAAATGGTGTGATTGGCACCTCAACACTACCTAAATACATAAAACCATTGGGTCCATACACATCTGATGCCACCACCATACAGTCACTAGCTACTGCTCTGCATGTATCATCACAGCCTATAACAGGCCAAACAGGCGCAAAGCAGGTGATACTCGAGAACCCGGGTGTTTTTTTAAACCCTGAACAGCCGCTGATCGCAGCGGTGACCATTACTAAAGACGATGTCCGGCGGCAAGAGGAGCGCGTTAAACGCGCGCGGATGCGACTACAGGAGGCTTTAGCAGCCGCGTAG
Protein Sequence
MNISIERKKMDCPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFHQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLSACDANGVIGTSTLPKYIKPLGPYTSDATTIQSLATALHVSSQPITGQTGAKQVILENPGVFLNPEQPLIAAVTITKDDVRRQEERVKRARMRLQEALAAA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090793;
90% Identity
iTF_00000356;
80% Identity
-