Mtil015520.1
Basic Information
- Insect
- Mimas tiliae
- Gene Symbol
- Mbd3
- Assembly
- GCA_905332985.1
- Location
- HG995254.1:6493390-6498484[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.8e-28 1.3e-24 85.9 0.0 1 72 5 71 5 75 0.95 2 2 0.0013 6.2 6.9 0.0 29 74 93 146 80 149 0.87
Sequence Information
- Coding Sequence
- ATGAACATCTCGATAGAGAAAAAAAGGTCGGATTGTGCTGCTTTGCCTAAGGGCTGGCAAAGAGAAGAGGTAATAAGAAAATCAGGCCTATCCGCGGGGAAACTTGATGTTTACTATTACAGTCCAACAGGTAAAAAGTTTCGCAGTAAGCCCGAGCTTGTGCGTTATCTCGGTGATAGTATGGACCTGTCGTGTTTCGACTTCCAACAGGGTCAGATAAACACAATGCTGCTGTGTAAGGCCAAGAAAGCACGAGCGCAGTTTGATTACAGGGGTGCACGAACCGACTCGTCCCTAGTGCCACCAATTCGTCAGACTGCATCTATTTTCAAACAACCTGTGACTGTATACAAAACGCAGGAGAGTAAAGTTAAAACTGATTTGAAACACGGTACACAGGAAAAACCGAAACAACTATTTTGGGAAAAGCGCCTGGAAGGCCTAACAGCGTGTGATGCGAATGGAGTTCTAGGAACAACCAGTTTGCCCAAGTACATCAAGTCCTTGGGACCATATACATCTGATGCCACGACGATACAATCCTTGGCGACTGCTCTACATGTGTCTTCGCAACCTATCACGGGACAGACCGGCTCCAAACAAGCCATAATGGAAAATCCGGGTGTTTTTCTAAATCCTGAGCAGCCGCTCATCGCGGCCGTGACCATAACTAAGGATGACGTGAGACGACAAGAGGAACGCGTACGTCGTGCGCGTCAGAGACTACAGAACGCGCTCGCCGTCGCATAG
- Protein Sequence
- MNISIEKKRSDCAALPKGWQREEVIRKSGLSAGKLDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGARTDSSLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDANGVLGTTSLPKYIKSLGPYTSDATTIQSLATALHVSSQPITGQTGSKQAIMENPGVFLNPEQPLIAAVTITKDDVRRQEERVRRARQRLQNALAVA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01090793;
- 90% Identity
- iTF_00000356;
- 80% Identity
- -