Prub016061.1
Basic Information
- Insect
- Plemyria rubiginata
- Gene Symbol
- Mbd3
- Assembly
- GCA_963576535.1
- Location
- OY754923.1:7093588-7097523[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.5e-27 1.3e-23 82.9 0.1 2 72 6 71 5 75 0.94 2 2 0.00064 2.3 8.4 0.0 29 74 93 146 79 149 0.88
Sequence Information
- Coding Sequence
- ATGAACATATCTATTGAGAAGAAAAGAACTGAATGTGCTGCATTGCCCAAAGGCTGGCAAAGAGAAGAAATTATAAGAAAAACTGGTCTTTCTGCTGGAAAGGTTGATGTTTACTACTATAGCCCTACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTTGTACGGTATCTCGGTGATAGTATGGACCTGTCATGTTTCGACTTCCAACAGGGTCAGATAAACACTATGCTGCTGTGCAAGGCCAAGAAAGCACGAGCGCAGTTTGATTACAGAGGTGCACGCTCTGATGCATCGTTAGTGCCCCCTATCCGGCAGACAGCATCAATATTCAAGCAACCTGTAACTGTGTATAAGACTCAGGAAAGCAAAGTTAAAACAGACTTGAAACATGGCACACAGGAAAAGCCCAAACAGTTGTTCTGGGAGAAACGCTTGGAAGGACTAACAGCCTGTGACGCGAATGGGGTTCTAGCCACAACTTCGCTGCCCAAGTATATCAGGCCATTGGGCCCTTATAACTCAGATGCCACTACAATACAATCCCTGGCAACTACGCTTCACGTCTCCTCACAACCTATAACAGGTCAACAAGGCTCAAAGCAAGTGATCTTAGAGAACCCTGGGGTGTTTCTGAATCCTGAACAGCCACTGATCGCTGCTGTCACCATCACCAAGGACGACGTTCGCAAGCAGGAGGAGCGTGTTTTGCGCGCGCGTAAACGACTGCAAGACGCTCTAGCGGTTGCCTAG
- Protein Sequence
- MNISIEKKRTECAALPKGWQREEIIRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGARSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDANGVLATTSLPKYIRPLGPYNSDATTIQSLATTLHVSSQPITGQQGSKQVILENPGVFLNPEQPLIAAVTITKDDVRKQEERVLRARKRLQDALAVA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01090793;
- 90% Identity
- iTF_00000356;
- 80% Identity
- -