Dpor023326.1
Basic Information
- Insect
- Deilephila porcellus
- Gene Symbol
- Mbd2
- Assembly
- GCA_905220455.1
- Location
- LR999986.1:5342006-5345984[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.4e-27 6.5e-24 83.7 0.0 1 72 5 71 5 75 0.95 2 2 0.00027 1.3 9.1 0.0 29 74 93 146 79 149 0.87
Sequence Information
- Coding Sequence
- ATGAATATCTCTATTGAGAAAAAGAGGTCTGACTGTGCAGCTTTGCCGAAAGGCTGGCAAAGAGAAGAGGTATTAAGAAAAACGGGCCTCTCCGCAGGGAAACTTGATGTTTACTATTACAGCCCAACAGGTAAAAAGATTCGCAGCAAGCCCGAGCTTGTGCGTTATCTTGGTGATAGTGTCGACCTGTCGTGTTTCGACTTCCAACAGGGTCAGATAAACACAGTGCTGCTGTGCAAGGCCAAGAAAGCACGAGCGCAGTTTGATTACAGGGGTGTCCGATCTGATGCATCCCTGGTGCCTCCAATCCGTCAGACTGCATCAATATTCAAGCAACCAGTGACGGTGTACAAGACACAGGAGAGTAAAGTAAAAACCGATCTAAAACACGGTACACAAGAGAAACCGAAGCAACTGTTTTGGGAAAAGCGGCTAGAAGGTCTAACAGCCTGTGATGCAAATGGAGTAATTGGAACAACTAGTTTACCCAAATACATCAAGTCACTGGGGCCGTACATATCTGACGCAACGACGATTCAGTCTTTGGCTACTGCCCTGCATGTGTCTTCGCAGTCCATTACGGGACAGACGGGTTCCAAACAAGCGATCATGGAGAACCCGGGAGTTTTTCTAAATCCTGAGCAGCCGCTCATCGCTGCCGTGACAATAACTAAAGAAGACGTCAGACGCCAGGAAGAGCGTGTGCGCCGCGCGCGCCAACGTCTGCAGGACGCGCTGGCGGTTGCCTAG
- Protein Sequence
- MNISIEKKRSDCAALPKGWQREEVLRKTGLSAGKLDVYYYSPTGKKIRSKPELVRYLGDSVDLSCFDFQQGQINTVLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDANGVIGTTSLPKYIKSLGPYISDATTIQSLATALHVSSQSITGQTGSKQAIMENPGVFLNPEQPLIAAVTITKEDVRRQEERVRRARQRLQDALAVA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01090793;
- 90% Identity
- iTF_00000356;
- 80% Identity
- iTF_00428144;