Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2e-27 8.6e-24 83.2 0.0 1 72 5 71 5 75 0.94

2 2 0.00026 1.1 9.2 0.0 29 74 93 146 78 149 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2e-27	8.6e-24	83.2	0.0	1	72	5	71	5	75	0.94
2	2	0.00026	1.1	9.2	0.0	29	74	93	146	78	149	0.86

Coding Sequence: ATGAACATATCTATCGAAAAGAAGAGGACCGATTGTCCTGCGTTACCTAAAGGATGGCAACGAGAAGAAGTTCTAAGAAAAAGCGGCCTTTCTGCTGGAAAAGTAGATGTGTATTATTATAGCCCAACAGGTAAAAAGTTTCGCAGTAAAGCTGAACTAGTTCGGTTTCTTGGTGATAGTATGGACCTGTCGTGTTTCGACTTCCAACAGGGTCAGATAAACACTATGCTGCTGTGCAAGGCCAAGAAAGCACGGGCTCAATTTGACTACAGGGGTGTAAGATCCGATGCGTCATTGGTGCCTCCAATACGTCAAACTGCATCCATTTTTAAACAACCGGTTACTGTATACAAAACACAAGAAAGCAAAGTAAAAACTGACTTAAAACATGGCACTCAAGAGAAACCTAAGCAATTATTTTGGGAGAAGAGATTGGAAGGACTGACGGCATGTGACGCAGATGGAGTCATAGGCACTACAACACTTCCCAAGTACATAAAGCCATTGGGACCATTTATATCAGATTCAACCACCATACAGTCGCTGGCCACAGCATTGCATGTATCTTCGCAACAAATAACAGGTCAGAGCGGACCGAAGCAAGTGATCCAAGACAATCCGAGCGTATTTTTGAATCCGGAACAGCCGCTGATAGCCGCGGTGACTATAACGAAGGAGGACGTGCGCAGACAGGAGGAGCGCGTGAAGCGCGCCCGACAGCGTCTGCAGGACGCTCTGGCGGTCTCGTAG
Protein Sequence: MNISIEKKRTDCPALPKGWQREEVLRKSGLSAGKVDVYYYSPTGKKFRSKAELVRFLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDADGVIGTTTLPKYIKPLGPFISDSTTIQSLATALHVSSQQITGQSGPKQVIQDNPSVFLNPEQPLIAAVTITKEDVRRQEERVKRARQRLQDALAVS

Sequence clustering based on sequence similarity using MMseqs2