Dspr012665.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila sproati
Gene Symbol
-
Assembly
GCA_018904355.1
Location
JAEIFY010000122.1:1998659-2005649[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 1.4e-05 0.00095 19.3 2.1 1 23 107 129 107 129 0.97
2 18 4.7e-06 0.00031 20.8 0.4 1 23 135 157 135 157 0.97
3 18 0.00069 0.046 14.0 0.9 1 23 163 185 163 185 0.95
4 18 9.9e-06 0.00066 19.8 3.1 1 23 191 213 191 213 0.97
5 18 2.2e-05 0.0015 18.6 4.7 1 23 219 241 219 241 0.99
6 18 4.1e-05 0.0028 17.8 5.7 1 23 247 269 247 269 0.97
7 18 2e-07 1.4e-05 25.1 4.3 1 23 275 297 275 297 0.98
8 18 7.2e-08 4.8e-06 26.5 2.4 1 23 303 325 303 325 0.97
9 18 4.2e-05 0.0028 17.8 6.7 1 23 332 354 332 354 0.97
10 18 7.3e-05 0.0049 17.0 6.5 1 23 360 382 360 382 0.98
11 18 6.5e-06 0.00044 20.3 4.5 1 23 388 410 388 410 0.98
12 18 4.7e-06 0.00032 20.8 8.1 1 23 416 438 416 438 0.98
13 18 3.8e-06 0.00026 21.0 7.6 1 23 444 466 444 466 0.97
14 18 4.3e-07 2.9e-05 24.0 7.7 1 23 472 494 472 494 0.98
15 18 0.00013 0.009 16.2 9.5 1 23 500 523 500 523 0.95
16 18 4.8e-05 0.0032 17.6 0.9 1 23 529 551 529 551 0.98
17 18 1.6 1.1e+02 3.4 0.4 13 23 576 586 573 586 0.87
18 18 5.9e-06 0.0004 20.5 1.6 1 23 592 615 592 615 0.96

Sequence Information

Coding Sequence
ATGCAGCACGTGAGCGCTGCCAGTTCGGCACCTTCGGTGGTTTCAGCACCGGTGGTGACCACTGGCGGTGGCACCACCATCACCTTGGGCGGACCGCCGTCATTGCCCGGTGTAAAATCGACGGAATCATCTCATAAAGAGGACGGCGGCAAGCAGCCGCCACACGGCATTGAAATGTATAAAGTGAACATTGAGGATATATCGCAGTTATTCACGTATCACGAGGTCTTTGGCAAAATCCACGGCGATGTGGTTAATCATGTGGCGGCGTCGAGCGTTGCGTTGGCGCCGGATGGCACGCCCATTGCGACTGGTACGCATGTGTGCGACATTTGTGGCAAGATGTTCCAGTTTCGCTATCAGCTGATTGTGCACCGCCGCTACCACAGCGAGCGCAAGCCGTTCATGTGTCAGGTGTGCGGTCAGGGTTTTACCACATCGCAGGATTTGACCCGTCATGGCAAGATCCACATTGGTGGTCCCATGTTCACGTGCATTGTCTGCTTCAATGTGTTTGCCAATAACACGAGTCTGGAGCGCCATATGAAACGGCATTCAACGGACAAGCCATTCGCCTGCACCATTTGCCAAAAGACTTTCGCACGCAAAGAGCATCTGGACAATCATTTTCGTTCGCATACGGGCGAAACGCCGTTCCGTTGCCAGTACTGCGCCAAGACGTTTACGCGCAAGGAGCACATGGTCAATCATGTGCGCAAACACACGGGTGAGACGCCACATCGTTGCGATATTTGTAAGAAGTCCTTCACGCGCAAGGAACACTATGTTAACCACTACATGTGGCACACTGGTCAAACACCGCATCAGTGCGATGTCTGCGGCAAGAAATACACGCGCAAGGAGCACCTAGCCAACCATATGCGCTCCCACACCAACGAGACGCCGTTCCGTTGCGAAATCTGCGGCAAGAGCTTTAGTCGCAAGGAGCACTTCACCAATCACATACTCTGGCATACAGCAGGTGAGACGCCGCATCGGTGCGACTTCTGCTCCAAGACGTTTACGCGCAAGGAGCATTTGTTAAATCATGTGCGCCAGCACACGGGAGAGTCGCCGCATCGCTGCTCCTACTGCATGAAGACGTTCACGCGCAAGGAGCATCTGGTGAATCATATACGCCAGCACACGGGTGAGACACCGTTCAAGTGCACGTACTGCACGAAAGCGTTCACACGCAAAGATCACATGGTTAATCATGTACGGCAACATACAGGCGAATCGCCGCACAAGTGCACATATTGCACCAAGACGTTTACGCGCAAGGAGCACCTCACCAATCATGTGCGACAGCATACGGGCGATTCGCCGCATCGCTGCTCCTACTGTAAGAAGACGTTCACCCGCAAGGAGCACCTGACGAATCATGTGCGTCTGCACACGGGCGACTCGCCGCACAAGTGCGAGTACTGTCAGAAGACGTTTACGCGCAAGGAGCATCTCAATAATCATATGCGCCAGCACTCCAGCGACAATCCCCATTGTTGCAACGTCTGCAACAAGCCCTTCACACGCAAGGAGCATCTGATCAATCATATGTCACGCTGCCACACCGGCGATCGTCCCTTCACCTGCGAGACGTGTGGCAAATCCTTCCCACTCAAGGGCAATCTGCTGTTCCATCAGCGCAGCCACACCAAGGGGCAGGAGTGCGAGCGTCCATTCGCCTGCGAGAAATATCTTCATGTCGCTTCCATTGTCCGTTTCGCAGGTCACTTGGTCTCGCACATGCGCTCCCATTCGGGAGAGAAACCGCACGCGTGCACACTGTGCAGCAAGGCGTTCGTCGAGCGCGGCAATTTGAAGCGCCACATGAAGATGAATCACCCGGATGCTATGATGCCGCCACCACCCGTGCATCCGCATCCGCAAATACCGGCTGGTGTGCTGACCCAAGTCAAGCAGGAAGTGAAACCGATCATAATTCCCCATCATTCGGCGACGACGACGATGCACACCATCCAGCAGATAACAGCGGGCGCCGCAGCGGCGGGCGCCGGGGCCGTCCAGTTAGCGCCAGGCCTGGTGCCGCTGGTCACCAGCTCGCTCATCTCGCACAATGCACAGCATGATCCGAGTGTGCTGGCACGTGCCGCCATGCAGCTGCAACATCTGCCCACAAATGTCGAACAGCATCCGGTGGTTTACTAA
Protein Sequence
MQHVSAASSAPSVVSAPVVTTGGGTTITLGGPPSLPGVKSTESSHKEDGGKQPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHVAASSVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTAGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQECERPFACEKYLHVASIVRFAGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAAAGAGAVQLAPGLVPLVTSSLISHNAQHDPSVLARAAMQLQHLPTNVEQHPVVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00599001; iTF_00915491; iTF_00514309; iTF_00585350; iTF_01556966; iTF_00600463; iTF_00579408; iTF_01555537; iTF_00475346; iTF_00587540; iTF_01551862; iTF_00586810; iTF_01548988; iTF_00541885;
90% Identity
iTF_00599001; iTF_00514309; iTF_00587540;
80% Identity
iTF_00599001;