Elun011158.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Eupeodes luniger
Gene Symbol
MBD2
Assembly
GCA_951509635.1
Location
OX608073.1:165129461-165130810[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.3e-24 4.6e-20 72.5 0.0 1 74 7 75 7 78 0.94
2 2 1.1e-05 0.12 13.6 0.0 27 74 171 227 149 230 0.85

Sequence Information

Coding Sequence
ATGAATCCCAACATAACTATTGAACGAAAGCGCATTGAATGCAATTCCCTCCCAAAAGGATGGCAACGAGAAGAAGTTCTTCGCAAATCTGGCATTTCAGCTGGAAAAGTTGATGTTTATTATTACAGtcCCAGTGGTAAGAAATTTGATAGTAAACCCCAACTAGCCCGACAACTAGGTGATACTATTGATATATCGGCATTTGACTTCCAATCTGGCAAGACAATACAAAGTCTGCCACCGCCATCCATATCTTTAAATCGTTGTAGCGGCTCATCGTCGAGCTCATTGAAACGCAAGTATAAGTGTCAATTTGGGGCTGGAGTTGGAGTTGGAGCTGGAACCGGAGCAGCACCAGCGACTCCATCACCGACAATACCACCAATTACATCGGCAGGTGGATTTGTTGGATCGACATCCTCTAGTTTCTCCCATAACATCTCAGCCACCAGTAGTAGCGGTAGTTCCTCACTTCCACCATCGACTCTAAGACATCATCTTGAGTTCAGCCGTGCTATTCGCACAGATGTATCTCTTGTACCTCCTATAAGACAGACAGCGTCAATTTTCAAGCAACCCGTCACTGTTGTTCGAAATCATGAAAACAGTAAAGTGAAGCATGATCTTAAGAATGGTAACCAAGAAAAACCAAAGCAGCTGTTCTGGGAAAAACGTCTAGAGGGCCTACGAGCATGCAATATTACGGGTGAGGAATTTGATAACATTGAGCTGCCGCGGGGTATAAGGTCCGTGGGACCGAACGTAGACGAGCAAACTGTTTTGCAGTCCGTAGCAACAGCACTACATGTACATAACCAACCTGTAACTGGACAAACATCTTCAAAGACAGAACTGACAAAGAACTCTGGAGCATTTTTGAACCCCGATCAGCCGTTAATGCAATCTATTGTCATATCAGAAGATGATATCCGTCGTCAAGAAGACCGCGTGAGTGTAGCCAGACGAAAGCTTCAGGAAGCTTTAAAGACTTAA
Protein Sequence
MNPNITIERKRIECNSLPKGWQREEVLRKSGISAGKVDVYYYSPSGKKFDSKPQLARQLGDTIDISAFDFQSGKTIQSLPPPSISLNRCSGSSSSSLKRKYKCQFGAGVGVGAGTGAAPATPSPTIPPITSAGGFVGSTSSSFSHNISATSSSGSSSLPPSTLRHHLEFSRAIRTDVSLVPPIRQTASIFKQPVTVVRNHENSKVKHDLKNGNQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIRSVGPNVDEQTVLQSVATALHVHNQPVTGQTSSKTELTKNSGAFLNPDQPLMQSIVISEDDIRRQEDRVSVARRKLQEALKT