Msca060206.1
Basic Information
- Insect
- Melanostoma scalare
- Gene Symbol
- MBD2
- Assembly
- GCA_949752695.1
- Location
- OX456986.1:167578251-167579570[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.4e-24 6.2e-20 72.5 0.0 1 74 7 75 7 78 0.94 2 2 2.6e-06 0.031 15.8 0.0 26 74 159 216 141 219 0.88
Sequence Information
- Coding Sequence
- ATGAATCCCCATATAACCATCGAACGTAAACGCATTGAGTGCAATTCTCTCCCTAAAGGATGGCAAAGAGAAGAGGTCCTACGAAAATCCGGTCTTTCTGCGGGAAAAGTTGATGTTTACTATTACAGTCCCAGTGGTAAGAAATTTGATAGTAAACCCCAACTAGCACGTCAACTAGGCGACACTGTTGATATATCGGCGTTTGATTTTCAATCGGGTAAGACCATACAAAACCTGCCACCGCCATCGATATCCTTGCATCGTTGTGGCGGCTCTTCGAGCTCACTTAAACGCAAGTATAAGACCCAATTCGGAATAGCAGCACCACCGGCCCCACAGACTACGCCACCATCTTCATGTGCCGGTGGATTTGGTGGGCCACCATCCTCTAGTTCCTCCCATAGCATCTCAGCATCCAGTAGTAGCGGTAGCTCCTCACTTGCACCATCGACTCTAAGACAGCATCTTGAGTTCAGCCGTGCTATTCGGACAGATGTCTCACTGGTACCGCCCATTAGACAAACCGCTTCTATCTTCAAGCAACCCGTAACCGTTATTCGTAACCACGAGAACGGCAAAGTAAAACATGATATGAAGAATGGCAATCAAGAAAAGCCGAAGCAACTCTTCTGGGAGAAACGCTTAGAGGGCCTTCGTGCATGCAATATTACTGGCGAAGAATTTGACAACATCGAACTACCCCGAGGCATAAGATCTGTGGGACCTAACGTCGACGAGCAGACAGTGCTTCAATCTGTAGCTACTGCTCTTCATGTGCTTAGCCAACCGGTAACAGGCCAGACTTCATCAAAGGTAGAGCTTACTAAGAATTCCGGGGCATTTCTTAACCCCGATCAGCCACTGATGCAGTCTATAGTCATCTCAGAAGACGACATCCGCCGCCAAGAAGACCGTGTCAATGTTGCCAGACGAAAACTTCAAGATGCCTTGAAGGTTTAG
- Protein Sequence
- MNPHITIERKRIECNSLPKGWQREEVLRKSGLSAGKVDVYYYSPSGKKFDSKPQLARQLGDTVDISAFDFQSGKTIQNLPPPSISLHRCGGSSSSLKRKYKTQFGIAAPPAPQTTPPSSCAGGFGGPPSSSSSHSISASSSSGSSSLAPSTLRQHLEFSRAIRTDVSLVPPIRQTASIFKQPVTVIRNHENGKVKHDMKNGNQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIRSVGPNVDEQTVLQSVATALHVLSQPVTGQTSSKVELTKNSGAFLNPDQPLMQSIVISEDDIRRQEDRVNVARRKLQDALKV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00694636;
- 90% Identity
- iTF_01541440;
- 80% Identity
- -