Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.1e-24 3.2e-20 72.6 0.0 1 74 7 75 7 78 0.94

2 2 9.2e-06 0.07 13.8 0.0 26 74 164 221 143 224 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.1e-24	3.2e-20	72.6	0.0	1	74	7	75	7	78	0.94
2	2	9.2e-06	0.07	13.8	0.0	26	74	164	221	143	224	0.86

Coding Sequence: ATGAATCCCAACATAACCATCGAAAGAAAGCGCATTGAATGCAATTCACTTCCTAAAGGATGGCAGCGGGAAGAAGTGCTTCGCAAGTCTGGCATTTCAGCCGGAAAAGTTGATGTTTATTATTACAGtccCAGTGGTAAGAAATTTGATAGTAAACCCCAACTAGCACGACAACTAGGTGACACTATCGATATATCGGCATTTGACTTCCAATCTGGCAAGACCATACAAAGTCTGCCACCGCCATCCATATCCTTACATCGTTGTGGCGGCTCATCATCGAGCTCATTGAAACGCAAGTATAAGTCTCAATTTGGAGCTGGAGCAGGAGCGGCACCAGCGATTCCATCACCGACAATACCACCATCTTCATCGGCCGGTGGATTTGTTGGCTCACCATCCTCTAGTTTCTCCCATAACATATCAGCCACCAGTAGTAGCGGTAGTTCCTCACTTCCACCATCGACTCTAAGACAACATCTTGAGTTCAGCCGTGCCATTCGCACAGATGTATCTCTTGTACCCCCTATTAGACAAACAGCATCTATTTTCAAACAACCTGTCACTGTTGTTCGGAATCATGAGAACGGCAAAGTGAAGCATGATCTCAAGAATGGCAATCAAGAAAAACCCAAACAACTATTCTGGGAAAAACGTCTAGAAGGCCTCCGGGCGTGCAACATCACCGGCGAAGAGTTTGATAACATTGAATTGCCTCGTGGTATAAGATCTGTGGGACCAAACGTAGACGAGCAAACCGTATTACAATCGGTAGCCACAGCACTGCATGTGCATAACCAGCCGGTAACTGGTCAAACATCGTCCAAAACTGAATTGACAAAGAATTCTGGAGCATTTTTGAATCCAGATCAGCCGTTAATGCAGTCGATTGTAATATCAGAAGATGATATTCGACGTCAGGAGGACCGGGTCAGTGTGGCCAGACGAAAACTTCAAGAAGCCTTGAAGATTTAA
Protein Sequence: MNPNITIERKRIECNSLPKGWQREEVLRKSGISAGKVDVYYYSPSGKKFDSKPQLARQLGDTIDISAFDFQSGKTIQSLPPPSISLHRCGGSSSSSLKRKYKSQFGAGAGAAPAIPSPTIPPSSSAGGFVGSPSSSFSHNISATSSSGSSSLPPSTLRQHLEFSRAIRTDVSLVPPIRQTASIFKQPVTVVRNHENGKVKHDLKNGNQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIRSVGPNVDEQTVLQSVATALHVHNQPVTGQTSSKTELTKNSGAFLNPDQPLMQSIVISEDDIRRQEDRVSVARRKLQEALKI

Sequence clustering based on sequence similarity using MMseqs2