Rros014037.1
Basic Information
- Insect
- Rhingia rostrata
- Gene Symbol
- MBD2
- Assembly
- GCA_949824845.1
- Location
- OX463756.1:123542170-123543481[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.3e-24 1.4e-20 73.4 0.0 1 75 7 76 7 78 0.94 2 2 1e-05 0.061 13.7 0.0 26 74 161 218 141 221 0.88
Sequence Information
- Coding Sequence
- ATGAATCCTAACATCACCATCGAACGTAAACGTGCCGAATGCAATTCCCTTCCAAAAGGATGGCAACGAGAAGAAGTCCTACGAAAGTCTGGCCTTTCTGCAGGGAAAGTTGATGTTTACTACTACAGtCCCAGTGGTAAGAAATTTGATAGTAAACCCCAACTAGCCCGTCAACTAGGCGACGCAATTGATATCTCAACGTTTGACTTTCAATCGGGTAAGACTATACAAAATTTACCACCGCCATCAATTTCTTTACATCGCTGTAGTAGCTCTTCACTGAGCTCTCTTAAGCGTAAATACAAGCCGCCAGTTACGGCAACAGCAACGGCAGCGACGCCGTCAACAACGCCTCCATCTACGTGTGCTGGTGGATTTGGTGGAGTGCCATCCTCTTGTACCTCCCATAGCATAACAGCATCAAGTAGTAGTGGTAGTTCCTCGCTTTCGTCGTCGACTTTAAGACAGCATCTTGAGTTCAGTCGTGCTATCCGCACAGATGTCTCATTGGTTCCGCCTATCAGGCAGACTGCATCCATTTTCAAGCAACCCGTCACGGTGGTTCGAAATCACGAGAACGGCAAAGTGAAGCATGACCTGAAGAACGGTAACCAAGAGAAGCCAAAGCAGCTATTCTGGGAGAAACGCTTGGAGGGCTTGCGTGCGTGCAATATTACCGGCGAGGAGTTCGATAACATCGAACTGCCACGTGGAATTCGATCCGTTGGACCAAATGTCGATGAACAAACAGTTTTGCAGTCGGTGGCGACTGCGTTACATGTACAAAATCAACCCGTAACCGGTCAGACCTCATCAAAGACAGAGTTGACCAAAAATTCTGGAGCATTTCTTAATCCCGACCAGCCACTGATGCAGTCAGTTGTTATATCAGAAGATGATATCCGCCGACAGGAGGATCGTGTCATTATGGCCAGACGAAAACTACAAGACGCCCTAAAAGCTTAG
- Protein Sequence
- MNPNITIERKRAECNSLPKGWQREEVLRKSGLSAGKVDVYYYSPSGKKFDSKPQLARQLGDAIDISTFDFQSGKTIQNLPPPSISLHRCSSSSLSSLKRKYKPPVTATATAATPSTTPPSTCAGGFGGVPSSCTSHSITASSSSGSSSLSSSTLRQHLEFSRAIRTDVSLVPPIRQTASIFKQPVTVVRNHENGKVKHDLKNGNQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIRSVGPNVDEQTVLQSVATALHVQNQPVTGQTSSKTELTKNSGAFLNPDQPLMQSVVISEDDIRRQEDRVIMARRKLQDALKA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00694636;
- 90% Identity
- iTF_01541440;
- 80% Identity
- -