Basic Information

Gene Symbol
MBD2
Assembly
GCA_932273905.1
Location
CAKNZR010000530.1:835174-836509[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-24 1.4e-20 74.0 0.0 1 75 7 76 7 78 0.94
2 2 1.5e-05 0.14 13.1 0.0 28 74 165 220 136 223 0.82

Sequence Information

Coding Sequence
ATGAATCCCAACATCACTATCGAACGTAAACGCATTGAATGCAATTCACTTCCAAAAGGATGGCAGCGAGAAGAAGTGCTTCGCAAATCTGGGATTTCAGCCGGAAAAGTTGATGTTTATTATTACAGTCCCAGTGGTAAGAAATTTGATAGTAAACCCCAACTAGCACGACAACTAGGTGAAACTATTGATATATCAGCATTTGACTTCCAATCTGGCAAGACCATTCATAGTCTGCCACCGCCATCCATATCCTTACATCGCTGTAGCGGCTCATCATCGAGCTCATTGAAACGCAAATATAAGTCTCAATTTGGAGTTGGAGCAGGAGCAGCACCAGCGATTCCATCACCGACAATACCAACATCTTCATCGCCCGGTGGATTTGTTGGATCACCGTCCTCTAGTTTCTCCCATAACATCTCAGCCACCAGTAGCGGTAGTTCCTCACTTCCACCATCGACTTTAAGACAACATCTTGAGTTCAGCCGTGTTATTCGCACAGATGTATCTCTTGTGCCTCCTATAAGACAGACAGCGTCTATTTTCAAACAACCTGTTACTGTTGTCCGTAACCATGAAAATGGCAAAGTGAAACATGATCTAAAGAATGGCAATCAAGAAAAACCAAAGCAACTATTCTGGGAAAAACGTCTAGAAGGCCTACGAGCTTGCAATATTACCGGCGAAGAGTTTGATAACATTGAGCTGCCTCGTGGTATAAGGTCTGTGGGACCGAACGTAGACGAGCAAACCGTATTGCAGTCCGTAGCCACAGCACTCCATGTGCATAATCAACCGGTAACTGGCCAGACATCTTCAAAAACAGAGTTGACAAAGAACTCTGGAGCGTTTTTGAATCCCGATCAACCTTTAATGCAGTCAATTGTAATATCAGAAGATGATATTCGTCGTCAGGAGGACCGCGTCAGTGTAGCCAGACGAAAACTTCAAGAAGCTTTAAAGACTTAA
Protein Sequence
MNPNITIERKRIECNSLPKGWQREEVLRKSGISAGKVDVYYYSPSGKKFDSKPQLARQLGETIDISAFDFQSGKTIHSLPPPSISLHRCSGSSSSSLKRKYKSQFGVGAGAAPAIPSPTIPTSSSPGGFVGSPSSSFSHNISATSSGSSSLPPSTLRQHLEFSRVIRTDVSLVPPIRQTASIFKQPVTVVRNHENGKVKHDLKNGNQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIRSVGPNVDEQTVLQSVATALHVHNQPVTGQTSSKTELTKNSGAFLNPDQPLMQSIVISEDDIRRQEDRVSVARRKLQEALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00694636;
90% Identity
iTF_00694636;
80% Identity
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