Esab002226.1
Basic Information
- Insect
- Eumerus sabulonum
- Gene Symbol
- MBD2
- Assembly
- GCA_951905685.1
- Location
- OX645060.1:31780657-31782049[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.3e-25 1.1e-21 77.4 0.0 1 75 7 76 7 78 0.95 2 2 1.1e-05 0.088 13.6 0.0 26 74 162 219 143 222 0.87
Sequence Information
- Coding Sequence
- ATGAATCCAAATATAACTATCGAACGTAAGCGCGTCGACTGCAATTCCCTTCCCAAAGGATGGCAACGAGAAGAGGTCCTACGAAAATCCGGCATCTCAGCGGGCAAAGTTGATGTTTACTATTACAGTCCCAGTGGTAAGAAAATTGATAGTAAACCCCAACTAGTACGTCAACTAGGCGACACGATTGATATTTCGGCATTTGACTTTCATACGGGTAAGACCATACAAAATCTGCCCCCGCCGTCGATTTCATTACAACGCTGTACCGGCTCGTCGACGAGCTCGCTCAAGCGTAAATATAAGCCTATGGTGACGGCAACGGCTACATCGAGCACCGCGTCAATGCCACCATGTTCGTCGGCAACCGGTGGATTTGGTGGAATATTATCCTCTAGTTCCTCCTATAGCATCTCAGCATCAAGCACTAGTAGTGGTAGTTCCTCACTTCCACCGTCGACACTCCGACAACAGCTTGAGTTCAGTAGGGCCATCCGGACGGATGTATCACTAGTGCCACCGATTCGACAGACTGCCTCGATATTCAAACAACCAGTTACTGTAGTGCGTAATCACGAGAATGGCAAGGTCAAGCATGATCTGAAGAATGGCAGTCAGGAGAAACCAAAACAACTCTTCTGGGAGAAACGGCTCGAAGGTCTGCGTGCGTGCAATATAACTGGCGAGGAATTTGATAATATTGAACTGCCGCGCGGGATAAAATCCGTTGGACCGAATGTCGACGAACAGACAGTTCTACAATCGGTGGCCACTGCTTTGCATGTACATAATCAGCCTGTGACCGGTCAAACATCATCGAAATCAGAATTGACGAAGAACTCCGGAGCGTTTCTCAATCCTGACCAGCCACTGATGCAATCAGTGGTCATATCAGAGGATGACATACGTCGGCAGGAGGATCGTGTAAATGTGGCCAGACGAAAACTTCAAGACGCACTGAAGTATTAG
- Protein Sequence
- MNPNITIERKRVDCNSLPKGWQREEVLRKSGISAGKVDVYYYSPSGKKIDSKPQLVRQLGDTIDISAFDFHTGKTIQNLPPPSISLQRCTGSSTSSLKRKYKPMVTATATSSTASMPPCSSATGGFGGILSSSSSYSISASSTSSGSSSLPPSTLRQQLEFSRAIRTDVSLVPPIRQTASIFKQPVTVVRNHENGKVKHDLKNGSQEKPKQLFWEKRLEGLRACNITGEEFDNIELPRGIKSVGPNVDEQTVLQSVATALHVHNQPVTGQTSSKSELTKNSGAFLNPDQPLMQSVVISEDDIRRQEDRVNVARRKLQDALKY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00694636;
- 90% Identity
- iTF_01541440;
- 80% Identity
- -