Dtak004199.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila takahashii
Gene Symbol
zfh1
Assembly
GCA_018152695.1
Location
JAECXN010000101.1:1816352-1822004[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 3.9e-05 0.0024 18.0 1.1 1 23 140 162 140 162 0.97
2 15 0.00081 0.05 13.9 1.2 3 23 170 190 168 190 0.94
3 15 0.00027 0.016 15.4 0.2 1 23 347 369 347 369 0.98
4 15 0.00061 0.038 14.3 0.8 1 23 375 397 375 397 0.98
5 15 1.1e-05 0.00069 19.7 2.0 1 23 428 450 428 450 0.97
6 15 0.0012 0.074 13.3 0.1 1 23 480 502 480 502 0.94
7 15 0.011 0.65 10.4 1.3 1 23 508 531 508 531 0.97
8 15 0.026 1.6 9.1 0.4 3 19 540 556 539 557 0.95
9 15 0.00015 0.0094 16.2 5.6 1 23 566 588 566 588 0.97
10 15 0.046 2.8 8.4 0.4 2 23 594 615 593 615 0.96
11 15 9e-06 0.00055 20.0 1.0 1 23 624 646 624 646 0.98
12 15 0.001 0.063 13.6 0.1 3 23 654 674 652 674 0.97
13 15 5.4e-05 0.0034 17.6 0.5 1 23 680 702 680 703 0.95
14 15 0.036 2.2 8.7 0.3 1 23 713 735 713 735 0.97
15 15 0.0054 0.33 11.3 0.2 1 23 1262 1284 1262 1284 0.97

Sequence Information

Coding Sequence
ATGAACAACCAGCGATATGGCGGCATCCAGTGGATACAGCACCACGTCTCCGCGGGCGACTCCTCCGAGGTGGACATCCTGGAGTCGGACGGCGGAGCGGGGGCGACGGGCGAGGATCTGGACCATATGGCGGCCGAGAATCTGATCTTCATGGCGCGCGACGGCCAGCTGAGCGAGATAATGGCGGCCAACGAGGCCGGCGGAACGGTCCTGGTGACCGCCGATGGCACCACGGTGGCCTATGCGGAATCCTTCGACGATGACGCGCAGGTGGTCACCGAGGAGGTCATCACGGACGACTGGGTGCAGCACCAAGGTGCCGAGCGTGTGGAAATCGCCGCGGAGCAGATAGCCGGGATTAGTAGCTCCCAGGAGCTGCTGGACATGGAGCAGGATGAGTACACCGCCCTCAGGCCATATCCCTGCGACTTCTGCAGTCGGCGCTTTCGGAAGAAGGCCACGTTGAATAACCACATGCTGGCCCACCAGAATGATCGACCGCATCTCTGCAAGCTGTGCGGAGCGCGCTTCTCTCGGCGGGCGGAGCTTATCAGTCACTTCAAGGCCCACGCAGAGGCCCAGGATGCAGCCGATGCCGAGGCAGCAGCAGCCGCCGCCGCCGCCGTGGATTCCTCTTCCGCCATCAAGTTTGAGCAGCAGACGCAGCGGCAGTTGGATGATCACTACTACGAGCATGACTGGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATTGTGGATGAGAGCGAGGTTCAGCTGGTGGCCAGCTACCCGGCGACGGCGACTGCTCCAGCAGCTCCGGCACGCGGCCGAATCAGCCGGCTGAAGCCCAAGGAGGAGAGCAGCCAGTTCATCGTGATTTCCGACAAGCCGGCGGGCAGCGAGTTGAGGCAGTACATGGACCCTGAGCCGACTCAGCCTATGGTCGTCACCACGTCGCAGGCAATTGCCGTTGACCCGCCTCCTCCTCCTCCTCCTCAGCCAAACTTTCCGGTGCTGGACGAGAGCAAACCCTTTGTTTGCCAGCAGTGCGGCCTGGCCTTTGCGCGGGAAAAGGCACTCGTCTCGCACACGAAGAACCACCGCGTGGACTCGCCGTTCGAGTGCAACCAGTGCCAGGAGATGTTCTGGGACAACAACAGCCTGCAGGAGCACCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAGTACGATCCCGCCTCGGCAGAGGATAGCGCCAGTGAATCGGAGCCCGAGGAGCAGCTGTATGGCGAATTCTATTGCAACGAGTGCGGGATCTCTTTCCATCGCCAGGATCTTTTGCGACGCCATGCCAAACTGCACTACAAGCAAACCGATCAGGCGGCCGCAGAAAGTAATTCCGATGTCACTGCTGGCGGTGATGTGGAGCTTGCCAAAGATTCTGCGGGTCACTCCTGCAACACATGCGGAAAGTCCTTTCCCAGCGCTTTGGAGATGCTCGCCCATGCTGAAATTCACGCTCGATTCCCGCCCTTCAAATGCGTCCTTTGTGGAATTAGCTTTTACGAGGAGCAGGCAATCAAGCGGCACCTGCACACCCGCCACCCCAGTGAACTGAAGGCCAACTCGTGTGTGCTGTGCGGCAAGGAGTGCCGCGATCGCAAGGCTCTGATTAAGCACGCCTGGGACCATTCGCGCGAGAAGTGCCACTCGTGCTCGAAATGCGGCAAGAACTTCCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGCGACAAATCGGTGGTGTGCGAGGTGTGCCAGGAGGAATTCCCCGACGGAAGGACTCTCTCCAACCACCGGCACTCGCACAGCACCACCTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAAACCTTTGGATCGCGTAGCTCCCAGCAGATCCACGTTCGCATTCACACCGGAGAGCGTCCATATGGCTGCCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGAACGCTGCGCAAGCACGAGCGGATCCACACGGGCGAGAAGCCATACGCTTGTTCCGTCTGTCCACGTGCCTTTAATCAACGGGTAGTGCTGCGCGAACACATTCGCTCCCATCATTCTGGGCTGGATGTGGCGCGAAATACGTACCACTGCACGGTCTGCTCCGAGGACCTGGCCTCGTCCAACGACCTCATCCAGCACCTCATCCAGCACAGTGACTCGAACACCGCCAAACAGCGACAGCCCATTACGGGGCCGCGCAAGTACAAGCGTCGACGAAAACTGCAGCCGCACGAGATTGCTCACATGCGGGCGGAGCACAAGGAGGCCAACGGTGAAGAGGAGGAGACAATCCTAGAGGGCGATGCCGAGGAATATGGCAGTGACATCGACCTCTGCGACTTTGATGTGGAGAATGTGGACGATCTGTTCGACATGGCCGAGTCGCCCAAAAAGGAGAAGCGAAAGAGGGGTTCGGCAGCCCCGAAGGCTGATCCCAAACCAGTGGCCAATGGCAAAGCGTCGAAAGCTGCCCACGAAAAGAACAAGGCCAAGCCGAGATACGATTCCACCAGCAGCCAGCAATCGGATCGCATCTGGGAGGAGAAGTTTCTGCACGACAGCCAAGTGGCTCTGTTTCAGATCGATTCGCTGGTGGTGGTCAATGATACTCATCTGCAGCCCGCTACCTCCGCTGTGTCTTCAAGCGTGCCCAACACAAGAGGCGGGGCCAAGCAGCAGCAGGCAAAACTGCAGGCAAAGCCTTCAGACGCAACTGCGACATCTGTTTCCACATCCTCCGCCTCCACTTCCACTTCCAGCAGTCGCAGCCGGAAGAAGGCAGCCACCAACAACAAGACTGTCAGCAAGGCACCACCGGCCAGCAACTCGCGGCCCCGAATGATTCACACAGAGAAGGCCAAGGTGCCAAGGGCTGCTGGCGGTGACTCCTCCAGCAGTGCGGCCAAAAAGTCGCGCACCAAGACCTACATCAGTCGCACGGAGACCAGCAAATTGGGCCTGGACAAGTCCCGCAGCAGTGCCTCAAACATGGTGGATGACTATGAGATCATTTCTCCAGCCACCCATCCTCCGAATCAGATCAGCTCCAGTCCCTTGCATATTAAACAAGAGCAGGAGCAACAGCAGCGGGTCCAGCTGATGTACGATGATAATCTACTGATAGACGCTGGTTTGCTCAGGGAGAAGACGTACGAGAAATTCAATCCGAGCATTGTCAACGATCTGGAGGAGATTTTGCGCTCGCCGCTGAAGCACGAGAGGAATTCCCGTCTGCGCTTCACCAGCGAATCCTCGACCACGCCACAGTTTTTGCCCGAGGAAGAGCAAAATCTGATCAAGATCGAGCCAACGTCTCCGGATTTACGGGAGATGGTGGAGAGCCAGCAAAGAGTCACGGCGCATGGCGGGAGCACTCCTTCGTCCTCTTCCTCTGCCAGAACTTCCAGACATCTGCGACAGATCACTGCCAACGGTGCACGGGCAGGGAGCAAGAGATCTGCAGCAGGAGTGGCCAGCAAGTCGTCACCAGCCCCGGCTGTAGCTGCAAAAAAGGGAAATACTGCCACCAAGGTCAGCAGCAGCAGCAGCTCTTCCTCGTACCTTAATTACGGTGTGGATTCCTACAACGTTAACCAGCGCCAGCTGGCCAGCAATGTCGATTTGGGGGGCGGATTCTTTTCCATCTCGGAGGTCGTGTCCGCAGCAGATGCCGCGGATGCGGCGGCCAAGGCGGCGGCTGCTGGTAAATCGGAGCGCAAATCCCGCAGCTTCGAGTGCGAAATGTGCTCGGCCATCTTTTATGATCGCGCCCAACTGCTGGAACATGTACACATCCACATTTAA
Protein Sequence
MNNQRYGGIQWIQHHVSAGDSSEVDILESDGGAGATGEDLDHMAAENLIFMARDGQLSEIMAANEAGGTVLVTADGTTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAAAAVDSSSAIKFEQQTQRQLDDHYYEHDWXXXXXXXXXXXXXXXXXXIVDESEVQLVASYPATATAPAAPARGRISRLKPKEESSQFIVISDKPAGSELRQYMDPEPTQPMVVTTSQAIAVDPPPPPPPQPNFPVLDESKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNNSLQEHQKTHQFEESNSEYDPASAEDSASESEPEEQLYGEFYCNECGISFHRQDLLRRHAKLHYKQTDQAAAESNSDVTAGGDVELAKDSAGHSCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKEANGEEEETILEGDAEEYGSDIDLCDFDVENVDDLFDMAESPKKEKRKRGSAAPKADPKPVANGKASKAAHEKNKAKPRYDSTSSQQSDRIWEEKFLHDSQVALFQIDSLVVVNDTHLQPATSAVSSSVPNTRGGAKQQQAKLQAKPSDATATSVSTSSASTSTSSSRSRKKAATNNKTVSKAPPASNSRPRMIHTEKAKVPRAAGGDSSSSAAKKSRTKTYISRTETSKLGLDKSRSSASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAGLLREKTYEKFNPSIVNDLEEILRSPLKHERNSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTAHGGSTPSSSSSARTSRHLRQITANGARAGSKRSAAGVASKSSPAPAVAAKKGNTATKVSSSSSSSSYLNYGVDSYNVNQRQLASNVDLGGGFFSISEVVSAADAADAAAKAAAAGKSERKSRSFECEMCSAIFYDRAQLLEHVHIHI