Basic Information

Insect: Drosophila santomea
Gene Symbol: zfh1
Assembly: GCA_016746245.1
Location: NC:16057811-16063372[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.3e-05 0.0021 18.0 1.1 1 23 140 162 140 162 0.97

2 15 0.00069 0.044 13.9 1.2 3 23 170 190 168 190 0.94

3 15 0.00023 0.015 15.4 0.2 1 23 341 363 341 363 0.98

4 15 0.00045 0.028 14.5 0.8 1 23 369 391 369 391 0.98

5 15 9.6e-06 0.00061 19.7 2.0 1 23 422 444 422 444 0.97

6 15 0.0024 0.15 12.2 0.7 1 23 474 496 474 496 0.93

7 15 0.009 0.57 10.4 1.3 1 23 502 525 502 525 0.97

8 15 0.022 1.4 9.2 0.4 3 19 534 550 533 551 0.95

9 15 0.00013 0.0083 16.2 5.6 1 23 560 582 560 582 0.97

10 15 0.039 2.5 8.4 0.4 2 23 588 609 587 609 0.96

11 15 7.7e-06 0.00049 20.0 1.0 1 23 618 640 618 640 0.98

12 15 0.00087 0.055 13.6 0.1 3 23 648 668 646 668 0.97

13 15 4.7e-05 0.003 17.6 0.5 1 23 674 696 674 697 0.95

14 15 0.0091 0.58 10.4 0.6 1 23 707 729 707 729 0.97

15 15 0.0046 0.29 11.3 0.2 1 23 1257 1279 1257 1279 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.3e-05	0.0021	18.0	1.1	1	23	140	162	140	162	0.97
2	15	0.00069	0.044	13.9	1.2	3	23	170	190	168	190	0.94
3	15	0.00023	0.015	15.4	0.2	1	23	341	363	341	363	0.98
4	15	0.00045	0.028	14.5	0.8	1	23	369	391	369	391	0.98
5	15	9.6e-06	0.00061	19.7	2.0	1	23	422	444	422	444	0.97
6	15	0.0024	0.15	12.2	0.7	1	23	474	496	474	496	0.93
7	15	0.009	0.57	10.4	1.3	1	23	502	525	502	525	0.97
8	15	0.022	1.4	9.2	0.4	3	19	534	550	533	551	0.95
9	15	0.00013	0.0083	16.2	5.6	1	23	560	582	560	582	0.97
10	15	0.039	2.5	8.4	0.4	2	23	588	609	587	609	0.96
11	15	7.7e-06	0.00049	20.0	1.0	1	23	618	640	618	640	0.98
12	15	0.00087	0.055	13.6	0.1	3	23	648	668	646	668	0.97
13	15	4.7e-05	0.003	17.6	0.5	1	23	674	696	674	697	0.95
14	15	0.0091	0.58	10.4	0.6	1	23	707	729	707	729	0.97
15	15	0.0046	0.29	11.3	0.2	1	23	1257	1279	1257	1279	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGCGATATGGCGGCATCCAGTGGATACAGCACCACGTCTCCGCGGGCGACTCCTCCGAGGTCGACATCCTGGAGTCGGATGGCGGAGCAGGGGCCTCGGGCGAGGATCTGGACCATATGGCGGCCGAGAATCTTATATTCATGGCCCGCGACGGTCAGCTGAGTGAGATAATGGCGGCCAACGAGGCGGGCAGAACCGTTCTGGTCACCGCCGACGGCACCACAGTTGCCTATGCGGAATCCTTCGACGATGACGCCCAGGTGGTCACCGAGGAGGTAATCACAGACGACTGGGTGCAGCACCAAGGCGCCGAGCGTGTGGAGATCGCTGCCGAGCAGATAGCTGGGATAAGCAGCTCACAGGAACTGCTGGACATGGAGCAGGATGAGTACACTGCGCTGAGGCCCTATCCCTGCGACTTTTGCAGTCGGCGCTTTCGCAAAAAGGCCACCCTAAATAACCATATGCTGGCCCATCAAAATGATCGACCGCATCTCTGCAAGCTGTGTGGAGCGCGATTCTCACGACGAGCAGAGCTCATCAGTCACTTCAAGGCCCACGCAGAGGCTCAGGATGCGGCCGATGCCgaagcagcagccgccgcagcCGATTCATCTTCTGCCATTAAGTTTGAGCATCAGACGCAGCGACAAATGGACGATCACTACTACGAGCAGGATTGGCCGCTTTTccaacagcaacaggagcaggaacaggcGCAACAGGAAATTCATCAACAGCATCAGATTGTGGAGGAGGGCGAGGTACAGCTGGTAGCCAGTTACCCAGCCACAGTGGCTCCACCAGCTGCTCCGTCACGGGGCAGAATCAGTCGGTTGAAGCCCAAGGAAGAGAGCAGCCAGTTCATTGTGATTTCCGACAAGTCGGCAGGCGATTCGGGGCCATACATGGAGCCTGAGCCAGCTCAGCCTGTGGTTACCACATCGCAGCCTATTGCCATCGACCCGCCTCCTCAGCCAAACTTTCCGGTGCTGGACGACAGCAAACCCTTTGTGTGTCAGCAATGCGGATTGGCGTTTGCGCGGGAAAAGGCACTCGTTTCACACACCAAGAATCACCGCGTGGATTCGCCCTTCGAATGCAACCAGTGTCAGGAGATGTTCTGGGATAATACAAGTTTGCAGGAGCACCAGAAGACCCATCAGTTCGAGGAGAGCAACTCGGAGTACGATCCTGCCTCGGCAGAGGATAGCGGCAGTGAATCGGAGCCCGACGAGCAGTTGTATGGCGAATTCTATTGCAACGAATGCGGGATCTCCTTTCATCGCCAGGATCTACTACGACGTCATGCCAAACTGCACTATAAGCCAACGGATCAGGCGGCTGGAGGAAGCAATTCCGATGTCACCGCTGGCGGAGATGAGGAGCATGCCAAAGATTCTACTGGCCACTGTTGCAACACTTGCGGAAAGTCCTTTCCTAGCGCTTTGGAGATGCTCGCCCATGCAGAAATCCACGCTAGGTTCCCGCCTTTCAAGTGCGTCCTATGCGGAATTAGCTTTTACGAGGAGCAGGCGATTAAGCGCCACCTGCACACCCGCCATCCCAGTGAACTGAAGGCCAATTCCTGCGTCCTGTGCGGCAAAGAGTGCCGCGATCGCAAGGCTCTGATAAAGCACGCCTGGGACCATTCGCGCGAGAAGTGCCATTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGTCTAAAGCGGCACATGGCTTCGCACCGCGACAAGTCGGTAGTATGCGAGGTGTGCCAGGAGGAATTCCCCGACGGACGAACGCTCTCCAACCACAGACACTCGCACAGCACTACCTCGCCCGGCAAGCTGTTCCCGTGCCACGAATGCGGCAAGACTTTCGGTTCGCGCAGCTCCCAGCAGATCCACGTGCGGATCCACACTGGCGAGCGGCCATATGGCTGCCGCTACTGCTGGAAGGCTTTCGCGGATGGTGGTACTCTGCGGAAGCACGAGAGGATCCACACCGGAGAAAAGCCGTATGCCTGCTCCGTCTGTCCACGCGCCTTTAATCAACGTGTCGTGCTGCGGGAACACATTCGTTCTCATCATTCTGGGCTGGATGTAGCGCGAAACACGTACCACTGCACAGTCTGCTCTGAAGACCTGTCAACTTCCAACGACCTTATCCAGCATCTGATCCAACATAGTGACTCGAACACAGCTAAGCAGCGACAGCCCGTCacGGGACCGCGCAAGTACAAGCGTCGCCGTAAGCTACAGCCTCACGAGATCGCTCACATGCGGGCGGAGAACAAGGATGGCAACGGTGAAGAGGAAGAGGCCGTAGGAGAAGGCGATGCAGAGGAGTATGCCAGTGACATCGATCTTTGCGACTTTGATGTGGAGAACGTGGACGATCTCTTTGACATGGCAGAATCACCTAAGAAAGAAAAGCGGAAGAGGGGCTCGACAGCCACAAAAGCTGATCCCAAAGCCATGACCAATGGGAAAGCAGTGAAACCTTCCCAGGATAAGGGCAAAGCTAAGCCAAGATATGACTCCATCAGCAGTCAGCAATCCGATCGCATTTGGGAGGAAAAGTTCCTGCACGACAGTCAAGTGGCTCTCTTTCAGATCGATTCGCTGGTAGTGGTCAATGACACTCATCTGCAACCCGCTAGCTCCGCTGTGTCTTCAAACATACCCAATACAAGAGGCGGATTGAAGCAGCAGGGAAAAGTGCAGGCGAAGTCTGTAGACGGAGCCGGAAATTTCAATAGCTCAGCTACCACATCTGTTCCTTCACTTTCCTCCTCCACTTCCAGCAGTCGGAGCAGGAAGAGGGCGGCAACCACTAAGCCAGCCAGCAAAGCACCTCCTGCCAGTAACTCGCGACCCCGAATGATTCACACAGAGAAAGCCAAGGTGCCAAGAGGTGTTGGCGGAGACTCCTCTAGTATTTCGGTAAAGAAAACGCGTTCCAAGACCTATATAAGTCGCACGGAGTCGAACAATCTAAGCCTCGACAAATCCCGCAGCAGTTCCTCAAACATGGTGGATGACTATGAAATCATTTCTCCAGCTACACATCCGCCAAATCAGATCAGCTCCAGTCCCTTACACAtcaaacaggagcaggagcaacaacagcggGTCCAACTTATGTACGATGATAACCTACTGATAGATGCTGCTCTGCTCAGGGAGAAGACGTATGAGAAGTTTAACCCGAGCATTGTTAATGATCTGGAGGAGATCCTGCGCTCTCCACTGAAGCACGAGAGAAACTCTCGCCTTCGCTTTACCAGCGAGTCTTCCACCACACCACAATATCTGCCCGAAGAGGAGCAAAACCTTATTAAAATTGAGCCAACTTCTCCAGATCTGCGGGAAATGTTGGAGAGCCAGCAAAGAGTCACAGCTCATAGCGGCGGCACTCCGTCGTCCTCTTCATCTGCCAGAACTTCCAGACATCTGCGACAAATCACTGCCAATGGTGCACGGGCAGGCAGCAAGAGATCTTCAGGTGGCGTAGCCAGCAAATCGTCAGCAGTCGCGGGAGTGGTGGCCAAAAAAGCGAACACTGCCACCAAGGTGAGCAGCAGCTCATCCTCGTACCTCTCATACGGGGTGGATTCCTACAATGTAAACGTACCTGCCAGTGCCAACAACACGGATGTGGGCAGCGGATTTTTTTCCATCTCGGAGGTTGTTTCGGCGGCCGACGCCGCAGATGCGGCTGCTAAAGCGGCGGCAGCTGGTAAATCGGAGCGGAAAACCCGCAGCTTCGAGTGCGAAATGTGCTCGGCCATCTTTTATGATCGCGCCCAGCTGCTGGAACACGTGCACATCCACATTTAA
Protein Sequence: MNNQRYGGIQWIQHHVSAGDSSEVDILESDGGAGASGEDLDHMAAENLIFMARDGQLSEIMAANEAGRTVLVTADGTTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQTQRQMDDHYYEQDWPLFQQQQEQEQAQQEIHQQHQIVEEGEVQLVASYPATVAPPAAPSRGRISRLKPKEESSQFIVISDKSAGDSGPYMEPEPAQPVVTTSQPIAIDPPPQPNFPVLDDSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNTSLQEHQKTHQFEESNSEYDPASAEDSGSESEPDEQLYGEFYCNECGISFHRQDLLRRHAKLHYKPTDQAAGGSNSDVTAGGDEEHAKDSTGHCCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLSTSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAENKDGNGEEEEAVGEGDAEEYASDIDLCDFDVENVDDLFDMAESPKKEKRKRGSTATKADPKAMTNGKAVKPSQDKGKAKPRYDSISSQQSDRIWEEKFLHDSQVALFQIDSLVVVNDTHLQPASSAVSSNIPNTRGGLKQQGKVQAKSVDGAGNFNSSATTSVPSLSSSTSSSRSRKRAATTKPASKAPPASNSRPRMIHTEKAKVPRGVGGDSSSISVKKTRSKTYISRTESNNLSLDKSRSSSSNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHERNSRLRFTSESSTTPQYLPEEEQNLIKIEPTSPDLREMLESQQRVTAHSGGTPSSSSSARTSRHLRQITANGARAGSKRSSGGVASKSSAVAGVVAKKANTATKVSSSSSSYLSYGVDSYNVNVPASANNTDVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRSFECEMCSAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00605719;
90% Identity: iTF_00592529;
80% Identity: -