Basic Information

Insect: Drosophila mimetica
Gene Symbol: zfh1
Assembly: GCA_037075245.1
Location: JBAMCH010000026.1:5658768-5662891[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4e-05 0.0031 18.0 1.1 1 23 140 162 140 162 0.97

2 15 0.00083 0.064 13.9 1.2 3 23 170 190 168 190 0.94

3 15 0.00027 0.021 15.4 0.2 1 23 346 368 346 368 0.98

4 15 0.00063 0.048 14.3 0.8 1 23 374 396 374 396 0.98

5 15 1.2e-05 0.00089 19.7 2.0 1 23 427 449 427 449 0.97

6 15 0.0012 0.095 13.3 0.1 1 23 479 501 479 501 0.94

7 15 0.011 0.83 10.4 1.3 1 23 507 530 507 530 0.97

8 15 0.027 2 9.2 0.4 3 19 539 555 538 556 0.95

9 15 0.00016 0.012 16.2 5.6 1 23 565 587 565 587 0.97

10 15 0.047 3.6 8.4 0.4 2 23 593 614 592 614 0.96

11 15 9.2e-06 0.00071 20.0 1.0 1 23 623 645 623 645 0.98

12 15 0.001 0.081 13.6 0.1 3 23 653 673 651 673 0.97

13 15 5.6e-05 0.0043 17.6 0.5 1 23 679 701 679 702 0.95

14 15 0.015 1.2 9.9 0.5 1 23 712 734 712 734 0.97

15 15 0.0055 0.42 11.3 0.2 1 23 1253 1275 1253 1275 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4e-05	0.0031	18.0	1.1	1	23	140	162	140	162	0.97
2	15	0.00083	0.064	13.9	1.2	3	23	170	190	168	190	0.94
3	15	0.00027	0.021	15.4	0.2	1	23	346	368	346	368	0.98
4	15	0.00063	0.048	14.3	0.8	1	23	374	396	374	396	0.98
5	15	1.2e-05	0.00089	19.7	2.0	1	23	427	449	427	449	0.97
6	15	0.0012	0.095	13.3	0.1	1	23	479	501	479	501	0.94
7	15	0.011	0.83	10.4	1.3	1	23	507	530	507	530	0.97
8	15	0.027	2	9.2	0.4	3	19	539	555	538	556	0.95
9	15	0.00016	0.012	16.2	5.6	1	23	565	587	565	587	0.97
10	15	0.047	3.6	8.4	0.4	2	23	593	614	592	614	0.96
11	15	9.2e-06	0.00071	20.0	1.0	1	23	623	645	623	645	0.98
12	15	0.001	0.081	13.6	0.1	3	23	653	673	651	673	0.97
13	15	5.6e-05	0.0043	17.6	0.5	1	23	679	701	679	702	0.95
14	15	0.015	1.2	9.9	0.5	1	23	712	734	712	734	0.97
15	15	0.0055	0.42	11.3	0.2	1	23	1253	1275	1253	1275	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGCGATATGGCGGAATCCAGTGGATACAGCACCACGTCTCCGCGGGCGACTCCTCTGAGGTGGACATCCTGGAGTCGGACGGTGGAGCTGGGGCGACGGGCGAGGATTTGGACCATATGGCGGCCGAGAATTTGATCTTCATGGCGCGCGACGGCCAACTGAGCGAGATAATGGCGGCCAATGAGGCCGGCGGAACGGTCCTGGTCACCGCCGATGGCACAACGGTGGCCTATGCGGAATCCTTCGACGATGACGCCCAAGTGGTCACCGAGGAGGTCATCACGGACGACTGGGTGCAGCACCAAGGCGCCGAGCGTGTGGAAATCGCCGCCGAGCAGATAGCCGGGATTAGTAGCTCCCAGGAACTGTTGGACATGGAGCAGGATGAGTACACCGCCCTGAGGCCGTATCCCTGCGACTTTTGCAGCCGTCGCTTTCGCAAGAAGGCCACGTTGAATAACCACATGCTGGCCCATCAGAATGATCGACCTCATCTCTGCAAGCTGTGCGGAGCGCGTTTCTCTCGGCGGGCAGAGCTCATTAGTCATTTTAAGGCCCATGCAGAGGCGCAGGATGCAGCCGATGCCGAGGCAGCGGCCGCCGCAGCCGATTCCTCTTCCGCCATCAAGTTTGAGCAACAGACGCAGCGGCAGTTGGACGATCACTATTATGAGCAGGACTGGCCACtttaccagcagcagcaggaacaggagcaggcgcagcaggagatgcagcagcatcatcatcatcagatTGTGGATGAGAGCGAGGTTCAGCTTGTGGCGAGCTACCCGGCTACGGTGGCTCCGCCAGCAGCTCCGGCACGCGGCAGAATCAGTCGGCTGAAGCCCAAGGAGGAGAGCAGCCAGTTCATCGTGATTTCCGACAAGCCGGCGAGCAGCGACTTGAGGCAGTACATGGACACTGAGCCGGCTCAGCCTATGGTCGCCCCTTCGCAGACAATAGCAGTCGACCCCCCTCCGCCTCCTCAGCCAAACTTTCCGGTGATCGACGACAGCAAACCATTCGTTTGCCAGCAGTGCGGATTGGCCTTTGCGCGGGAAAAGGCTCTGGTCTCGCACACGAAGAACCACCGCGTGGACTCGCCGTTCGAATGCAACCAGTGCCAGGAAATGTTCTGGGACAACAACAGCCTGCAGGAACACCAGAAGACGCATCAGTTTGAGGAGAGCAACTCGGAGTACGATCCCGCCTCTGCAGAGGATAGCGCTAGCGAATCGGAGCCCGAGGAGCAATTGTATGGCGAATTCTATTGCAACGAATGCGGGATCTCTTTCCATCGCCAAGATCTGCTGCGCCGTCATGCCAAACTACACTACAAGCAAACGGATCAGGCGGCCGCAGAGAGCAATTCCGACGTCACTGCTGGCGGGGATGTGGAGCTTGCCAAAGATTCTGGGGGTCACTCTTGTAACACATGCGGAAAGTCCTTCCCCAGCGCTTTGGAGATGCTCGCCCATGCCGAAATCCACGCTCGGTTCCCGCCCTTCAAATGCGTCCTTTGCGGAATAAGCTTTTACGAGGAGCAGGCAATCAAGCGGCACCTGCACACCCGCCACCCCAGTGAACTGAAGGCCAACTCCTGCGTGCTGTGCGGCAAGGAGTGCCGCGATCGCAAGGCTCTTATCAAGCACGCATGGGACCATTCGCGCGAGAAGTGTCACTCGTGCTCCAAGTGCGGCAAGAACTTCCATAACAAGGCGCGCCTGAAGCGGCATATGGCCTCGCATCGCGACAAGTCGGTGGTGTGCGAGGTGTGCCAGGAGGAGTTCCCCGACGGACGAACACTCTCCAACCACCGGCACTCGCACAGCACTACCTCACCTGGCAAGCTGTTTCCGTGCCACGAGTGCGGGAAGACCTTCGGATCGCGTAGCTCTCAGCAGATCCACGTTCGCATTCACACTGGAGAGCGTCCTTATGGCTGCCGCTACTGCTGGAAGGCCTTCGCTGATGGTGGCACGCTGCGCAAACACGAGCGGATCCACACGGGCGAGAAGCCATATGCCTGCTCTGTCTGTCCTCGTGCCTTTAATCAAAGGGTGGTGCTGCGGGAACACATCCGCTCCCACCACTCTGGTCTTGATGTGGCGCGAAATACGTACCACTGCACTGTCTGCTCCGAGGATCTGTCCTCGTCTAATGACCTCATCCAGCACCTCATTCAACACAGTGACTCAAACACCGCCAAACAGCGACAACCGATTaCTGGTCCGCGCAAGTACAAACGTAGACGAAAGCTGCAGCCGCACGAGATTGCTCACATGCGGGCGGAAAACAAAGACGCCAACGGCGAAGAGGAGGACGCCATTCTAGAAGGCGAAGCTGAGCAGTACGGCAGTGATATCGACCTTTGCGACTTTGATGTGGAGAATGTTGACGATCTGTTTGACATGGCCGAATCGCCCAAGAAGGAGAAACGAAAGAGGGGCCCGGCAGCACCGAAGGTTGATACTAAGCCCGTGACCAATGGCAAAGCTGCGAAACCTGCCCAGGAAAAGAGCAAGGCAAAGCCGAGATACGATTCTACCAGCAGTCAGCAATCGGATCGCATCTGGGAGGAGAAGTTTCTGCACGACAGTCAAGGTGGTCTCTTTCAGATCGATTCGCTGGTGGTGGTCAACGATACTCATCTGCAGCCCGCCACCTCCGCTGGTTCTTCAGCTATACCCAACACAAGGAGTGGGGCCAAGCAGCAGGGAAAACAGCAGGCAAACCCTGCAGAAGGATCTGGGAATTTCAATGCCTCCGGTGCGACATCTGTTTCCACATCCTCCGCCTCCACTTCCAGCAGTCGCAGCCGAAAAAAGGCTGCAACCAACAAGACTGCCAGCAAAGCACCACCTGCCGGCAATTCGCGACCCCGAATGATACACACAGAAAAGGCCAAGGTTCCGAAGGGAGCTGGCGCCGACTCCTCTGGCAGTGCGGCCAAGAAGTCGCGCTCCAAGACCTACATCAGTCGCACGGAGACTAGCAATTTGGGACTTGACAAGTCTCGCAGCAGTGCCTCAAACATGGTGGATGACTATGAGATAATTTCTCCAGCCACCCATCCACCGAATCAAATCAGCTCCAGTCCATTGCACATTAAACAAGAgcaggagcaactgcagcggGCCCAGCTAATGTACGATGATAATCTCCTGATAGATGCTGGTTTGCTTAGGGAAAAGACTTACGATCTGGAGGATATTCTGCGCTCGCCACTGAAGCACGAGAGGAATTCCCGTCTGCGCTTCACCAGCGAATCGTCGACTACGCCACAGTTTTTGCCCGAGGAAGAGCAAAATCTGATCAAGATCGAGCCAACGTCTCCAGACTTGCGGGAGATGGTGGAGAGCCAGCAGAGAGTCACAGCTCATAGCGGTAGCACTCCTTCGTCCTCTTCCTCTGCCAGAACTTCCAGACATCTGCGACAGATCACTGCCAACGGTGCACGGGCAGGGAGCAAGAGATCTGCAGGAGGAGAAGCTAGCAAATCTTCACCAGCCACGGGAGTAGCggcaaaaaaagcaaacactGCCACCAAGGTCAGCAGCAGCTCTTCCTCGTACCTCGGCTATGGTGTGGATTCTTACAACGTTAACCAGCGTCAGCTGGCCAGCAATGCCGATGTAGGTAGCGGATTCTTTTCCATCTCGGAAGTCGTATCCGCAGCAGATGCCGCCGATGCGGCGGCCAAGGCGGCGGCTGCTGGTAAATCGGAACGGAAAACCCGCAGCTTTGAGTGCGAAATGTGCTCGGCCATCTTTTATGATCGCGCCCAACTGCTGGAACATGTACACATCCACATTTAA
Protein Sequence: MNNQRYGGIQWIQHHVSAGDSSEVDILESDGGAGATGEDLDHMAAENLIFMARDGQLSEIMAANEAGGTVLVTADGTTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEQQTQRQLDDHYYEQDWPLYQQQQEQEQAQQEMQQHHHHQIVDESEVQLVASYPATVAPPAAPARGRISRLKPKEESSQFIVISDKPASSDLRQYMDTEPAQPMVAPSQTIAVDPPPPPQPNFPVIDDSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNNSLQEHQKTHQFEESNSEYDPASAEDSASESEPEEQLYGEFYCNECGISFHRQDLLRRHAKLHYKQTDQAAAESNSDVTAGGDVELAKDSGGHSCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLSSSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDANGEEEDAILEGEAEQYGSDIDLCDFDVENVDDLFDMAESPKKEKRKRGPAAPKVDTKPVTNGKAAKPAQEKSKAKPRYDSTSSQQSDRIWEEKFLHDSQGGLFQIDSLVVVNDTHLQPATSAGSSAIPNTRSGAKQQGKQQANPAEGSGNFNASGATSVSTSSASTSSSRSRKKAATNKTASKAPPAGNSRPRMIHTEKAKVPKGAGADSSGSAAKKSRSKTYISRTETSNLGLDKSRSSASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQLQRAQLMYDDNLLIDAGLLREKTYDLEDILRSPLKHERNSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTAHSGSTPSSSSSARTSRHLRQITANGARAGSKRSAGGEASKSSPATGVAAKKANTATKVSSSSSSYLGYGVDSYNVNQRQLASNADVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRSFECEMCSAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00605719;
90% Identity: iTF_00581679;
80% Identity: -