Basic Information

Insect: Drosophila eugracilis
Gene Symbol: zfh1
Assembly: GCA_018153835.1
Location: NW:67792-72347[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.4e-05 0.0022 18.0 1.1 1 23 140 162 140 162 0.97

2 15 0.00071 0.045 13.9 1.2 3 23 170 190 168 190 0.94

3 15 0.00023 0.015 15.4 0.2 1 23 339 361 339 361 0.98

4 15 0.00011 0.0071 16.4 0.7 1 23 367 389 367 389 0.98

5 15 9.9e-06 0.00063 19.7 2.0 1 23 420 442 420 442 0.97

6 15 0.0025 0.16 12.2 0.7 1 23 472 494 472 494 0.93

7 15 0.0093 0.59 10.4 1.3 1 23 500 523 500 523 0.97

8 15 0.023 1.4 9.2 0.4 3 19 532 548 531 549 0.95

9 15 0.00013 0.0085 16.2 5.6 1 23 558 580 558 580 0.97

10 15 0.04 2.5 8.4 0.4 2 23 586 607 585 607 0.96

11 15 7.9e-06 0.0005 20.0 1.0 1 23 616 638 616 638 0.98

12 15 0.00089 0.057 13.6 0.1 3 23 646 666 644 666 0.97

13 15 4.8e-05 0.003 17.6 0.5 1 23 672 694 672 695 0.95

14 15 0.032 2 8.7 0.3 1 23 705 727 705 727 0.97

15 15 0.0047 0.3 11.3 0.2 1 23 1253 1275 1253 1275 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.4e-05	0.0022	18.0	1.1	1	23	140	162	140	162	0.97
2	15	0.00071	0.045	13.9	1.2	3	23	170	190	168	190	0.94
3	15	0.00023	0.015	15.4	0.2	1	23	339	361	339	361	0.98
4	15	0.00011	0.0071	16.4	0.7	1	23	367	389	367	389	0.98
5	15	9.9e-06	0.00063	19.7	2.0	1	23	420	442	420	442	0.97
6	15	0.0025	0.16	12.2	0.7	1	23	472	494	472	494	0.93
7	15	0.0093	0.59	10.4	1.3	1	23	500	523	500	523	0.97
8	15	0.023	1.4	9.2	0.4	3	19	532	548	531	549	0.95
9	15	0.00013	0.0085	16.2	5.6	1	23	558	580	558	580	0.97
10	15	0.04	2.5	8.4	0.4	2	23	586	607	585	607	0.96
11	15	7.9e-06	0.0005	20.0	1.0	1	23	616	638	616	638	0.98
12	15	0.00089	0.057	13.6	0.1	3	23	646	666	644	666	0.97
13	15	4.8e-05	0.003	17.6	0.5	1	23	672	694	672	695	0.95
14	15	0.032	2	8.7	0.3	1	23	705	727	705	727	0.97
15	15	0.0047	0.3	11.3	0.2	1	23	1253	1275	1253	1275	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGCGATATGGCGGAATCCAGTGGATACAGCACCACGTCTCCGCGGGCGACACCTCAGAGGTGGACATCTTGGAGTCGGATGGCGGAGGCGGGAATACAGGAGAGGATCTGGATCATATGGCGGCtgagaatttaatttttatggctcGCGACGGCCAGCTGAGCGAGATAATGGCGGCCAATGAGTCGGGCGGAACGGTCTTGGTCACCGCCGATGGAACAACTGTGGCTTATGAGGAATCTTTCGACGATGACGCCCAAGTGGTCACCGAGGAGGTTATTACAGACGACTGGGTGCAGCATCAGGGAGCCGAACGTGTGGAGATTGCCGCTGAGCAAATAGCTGGAATAAGCAGCTCACAGGAACTTCTGGACATGGAACAGGATGAATACACCGCTCTCAGGCCGTATCCCTGCGACTTCTGTAGTAGACGCTTTCGGAAGAAGGCCACCTTGAATAATCACATGCTGGCCCACCAAAACGATAGACCGCATCTCTGCAAACTGTGTGGAGCTCGATTCTCAAGACGGGCGGAGCTAATTAGCCACTTCAAGGCCCACGCCGAGGCCCAGGATGCAGCGGATGCAGAGgcagcagctgccgctgctgatTCCTCCTCCGCCATTAAGTTTGAGCACCAGTCGCAGCGGCAGTTGGACTACGAGCATGATTGGCCAATctatcaacagcaacaggaacCAGATCAGGTGCAACAGGAGATACAGGAACACCACCATATTGCGGAAGAGGGTGAAGTTCAGTTGGTGGCCAGCTACCCGGCCCCTGTTGCTCCACCGCCAGCTCCTTCACGAGGTAGAATTAGTCGTCTAAAGCCCAAGGAGGAGAGCAGCCAGTTCATCGTGATTTCTGATAAGTCGGGGCAAAGCGAGTTGAGGCAGTACATGGATACTGAGCCAGCTCAGCCTGTGGTCACCACGTCACAGCCCATCGCCGTTGAACCTCCTCCCCAACCAAACTTCCCAGTGCTTGACGACAGCAAACCCTTTGTGTGCCAGCAGTGCGGATTAGCGTTTGCGCGGGAAAAGGCACTCGTCTCACACACGAAGAACCACCGAGTGGACTCGCCTTTCGAGTGTAACCAGTGTCAGGAAATGTTTTGGGACAACAGCAGTCTTCAAGAACACCAGAAGACGCACCAGTTCGAGGAGAGTAATTCGGAGTACGATCCTGCCTCGGCTGAAGATTCCGCCAGCGAATCTGAACCCGAGGAGCAGTTATATGGCGAATTCTATTGCAACGAATGCGGGATATCTTTCCATCGACAGGATCTGCTGCGACGCCATGCCAAACTTCACTACAAGCAAACGGATACGGCCGCCGTAGAAAACAATTCCGATGTCACTGCTGGCGGAGATGTGGAGCTTGCCAAAGATTCTACCGGCCACTGTTGCAACACATGCGGAAAGTCATTTCCCAGCGCGTTGGAGATGTTGGCTCATGCCGAAATCCACGCTCGGTTCCCGCCCTTTAAgTGCGTCCTATGTGGTATCAGCTTTTACGAAGAGCAGGCCATTAAGCGGCACCTGCACACCCGCCATCCAAGTGAATTGAAAGCTAACTCCTGCGTGTTATGCGGCAAGGAGTGCCGCGATCGAAAGGCCCTGATTAAGCACGCCTGGGATCATTCACGGGAAAAGTGTCATTCGTGCTCTAAGTGCGGCAAGAACTTCCACAATAAGGCGCGCCTAAAGCGGCACATGGCATCACATCGCGACAAGTCGGTAGTGTGCGAGGTGTGCCAGGAAGAATTTCCCGATGGGCGAACGCTCTCCAACCATAGGCACTCGCACAGCACCACATCTCCGGGTAAGCTTTTTCCGTGCCACGAGTGCGGAAAGACTTTTGGCTCGCGTAGCTCTCAGCAGATTCATGTTCGTATTCATACTGGCGAGCGGCCATATGGGTGCCGGTATTGCTGGAAGGCTTTCGCAGACGGCGGCACACTGCGAAAGCATGAGCGCATCCACACGGGCGAGAAGCCGTACGCATGTTCCGTTTGCCCGCGAGCCTTTAATCAGCGGGTGGTGCTACGAGAACACATCCGCTCCCATCATTCTGGGTTGGATGTAGCACGGAATACGTACCATTGCACGGTCTGCTCCGAGGATTTGGCATCGTCCAACGACCTTATCCAACACCTTATTCAACACAGTGACTCAAACACCGCCAAACAGCGACAACCCATTACTGGTCCACGCAAGTACAAGCGCCGTCGCAAACTGCAGCCGCACGAGATCGCTCACATGCGAGCCGAGCACAAAGGCGCCGACGGCGAAGAGGAAGAGGCCGCAGATGGGGGTGAAGCCGAGGAGTATGCCAGTGACATCGACCTTTGCGACTTTGATGTAGAGAACGTAGACGATATATTTGACATGGCAGATTCACCCAAAAAGGAGAAGCGAAAAAGAGGATCGGCAGCGCCAAAGCCTGATAACAAACCCGTTACCAATGGAAAAACAGTGAAGCCTGCCCAAGACAAGTATAAGGGTAAGACCCGTTACGACTCCACCAGCAGCCAACATTCGGATCGGATCTGGGAAGAAAAGTTCCTGCAAGACAGCCAAGTTGCTTTATTTCAAATCGATTCGCTGGTAGTGGTCAACGATACTCATCTGCAGCCCGCTAGCTCCTCCTTGACAGCAACCATACCCAATACaagaaacagcagcaggcaTCAGGGAAAAGTTCAGACAAAGCCTGTAGAACAGGCTGGAAATTTGAATACCTCTGCAACTACTTCCGTTACGACATCCTCGGCATCCACTTTTAATAGTCGGAGCAGGAAGAAGGCAGGAAACACAAAGACTGCCAGCAAAGCTTCACCTGTCAGCAATTCGCGACCGAAAATGATTCACACGGAGAAGGCTAAGGTTCCCAGGGGAACGAGCTCAGAATATTCCAGCAGTGCGGCAAAGAAAACGCGCTCGAAGACCTATATCAATCGCACGGAGACTAGTAATCTGGGCCTGGACAAATCTCGCAACAGTGCCTCAAACATGGTGGATGACTACGAGATCATTTCGCCAGCCACCCATCCACCGAATCAAATCAGCTCTAGCCCTTTGCACATCAAACAGGaacaggagcaacagcagcgtGTCCAACTGATTTATGATGACAATCTCCTAATAGACGCTGGTCTTCTTCGGGAGAAATACGAGAAATACAACCAGCCGATTGTTAATGATCTTGAGGAGATTCTGCGATCTCCATTAAAGCACGAGAGAAATTCTCGACTGCGATTCACTAGCGAATCGTCAACCACGCCACAGTTTATCCACGAAGAAgaacaaaatttaatcaagATCGAGCCCACGTCACCAGATTTGCGAGATATGGTAGAGAGCCAGCAAAGAGTCACAGCTCATAGTGGAAGCACGCCTTCGTCTTCTTCTGCGAGAACTTCCAGACATCTCCGACAGATCACAGCCAATGGTACACGGGCAGGAAGCAAGAGATCTGCTGGAAGCATCGCCAGCAAATCCTCACCAGTCTCGCAGGTATTGCCGAAAAAGGCTAACACTGCCTCAAAGGTCAACAACAGTTCATCTTCGTACCTCAGTTACGGAGTGGATTCCTACAATGTGAACGTACCTGCCAGCGCCAATAATGCCGATGTGGGCAGCGGATTCTTTTCCATTTCGGAAGTGGTCTCTGCAGCTGATGCCGCAGATGCGGCAGCCAAGGCGGCGGCAGCTGGTAAATCAGAGCGGAAAACTCGTAGCTTTGAATGCGAAATGTGCTCGGCTATTTTCTATGATCGCGCCCAACTGCTGGAACATGTCCATATCCACATTTAG
Protein Sequence: MNNQRYGGIQWIQHHVSAGDTSEVDILESDGGGGNTGEDLDHMAAENLIFMARDGQLSEIMAANESGGTVLVTADGTTVAYEESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQSQRQLDYEHDWPIYQQQQEPDQVQQEIQEHHHIAEEGEVQLVASYPAPVAPPPAPSRGRISRLKPKEESSQFIVISDKSGQSELRQYMDTEPAQPVVTTSQPIAVEPPPQPNFPVLDDSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNSSLQEHQKTHQFEESNSEYDPASAEDSASESEPEEQLYGEFYCNECGISFHRQDLLRRHAKLHYKQTDTAAVENNSDVTAGGDVELAKDSTGHCCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKGADGEEEEAADGGEAEEYASDIDLCDFDVENVDDIFDMADSPKKEKRKRGSAAPKPDNKPVTNGKTVKPAQDKYKGKTRYDSTSSQHSDRIWEEKFLQDSQVALFQIDSLVVVNDTHLQPASSSLTATIPNTRNSSRHQGKVQTKPVEQAGNLNTSATTSVTTSSASTFNSRSRKKAGNTKTASKASPVSNSRPKMIHTEKAKVPRGTSSEYSSSAAKKTRSKTYINRTETSNLGLDKSRNSASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLIYDDNLLIDAGLLREKYEKYNQPIVNDLEEILRSPLKHERNSRLRFTSESSTTPQFIHEEEQNLIKIEPTSPDLRDMVESQQRVTAHSGSTPSSSSARTSRHLRQITANGTRAGSKRSAGSIASKSSPVSQVLPKKANTASKVNNSSSSYLSYGVDSYNVNVPASANNADVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRSFECEMCSAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00605719;
90% Identity: -
80% Identity: -