Basic Information

Insect: Drosophila subpulchrella
Gene Symbol: zfh1
Assembly: GCA_014743375.2
Location: NC:15127068-15132787[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.9e-05 0.0023 18.0 1.1 1 23 140 162 140 162 0.97

2 15 0.00082 0.047 13.9 1.2 3 23 170 190 168 190 0.94

3 15 0.00027 0.015 15.4 0.2 1 23 342 364 342 364 0.98

4 15 0.00052 0.03 14.5 0.8 1 23 370 392 370 392 0.98

5 15 2.4e-05 0.0014 18.7 2.4 1 23 423 445 423 445 0.98

6 15 0.0015 0.089 13.0 0.1 1 23 475 497 475 497 0.94

7 15 0.011 0.61 10.4 1.3 1 23 503 526 503 526 0.97

8 15 0.026 1.5 9.2 0.4 3 19 535 551 534 552 0.95

9 15 0.00015 0.0089 16.2 5.6 1 23 561 583 561 583 0.97

10 15 0.046 2.6 8.4 0.4 2 23 589 610 588 610 0.96

11 15 9e-06 0.00052 20.0 1.0 1 23 619 641 619 641 0.98

12 15 0.001 0.059 13.6 0.1 3 23 649 669 647 669 0.97

13 15 5.5e-05 0.0032 17.6 0.5 1 23 675 697 675 698 0.95

14 15 0.036 2.1 8.7 0.3 1 23 708 730 708 730 0.97

15 15 0.0054 0.31 11.3 0.2 1 23 1251 1273 1251 1273 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.9e-05	0.0023	18.0	1.1	1	23	140	162	140	162	0.97
2	15	0.00082	0.047	13.9	1.2	3	23	170	190	168	190	0.94
3	15	0.00027	0.015	15.4	0.2	1	23	342	364	342	364	0.98
4	15	0.00052	0.03	14.5	0.8	1	23	370	392	370	392	0.98
5	15	2.4e-05	0.0014	18.7	2.4	1	23	423	445	423	445	0.98
6	15	0.0015	0.089	13.0	0.1	1	23	475	497	475	497	0.94
7	15	0.011	0.61	10.4	1.3	1	23	503	526	503	526	0.97
8	15	0.026	1.5	9.2	0.4	3	19	535	551	534	552	0.95
9	15	0.00015	0.0089	16.2	5.6	1	23	561	583	561	583	0.97
10	15	0.046	2.6	8.4	0.4	2	23	589	610	588	610	0.96
11	15	9e-06	0.00052	20.0	1.0	1	23	619	641	619	641	0.98
12	15	0.001	0.059	13.6	0.1	3	23	649	669	647	669	0.97
13	15	5.5e-05	0.0032	17.6	0.5	1	23	675	697	675	698	0.95
14	15	0.036	2.1	8.7	0.3	1	23	708	730	708	730	0.97
15	15	0.0054	0.31	11.3	0.2	1	23	1251	1273	1251	1273	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGCGATATGGCGGAATCCAGTGGATACAGCACCACGTCTCCGCGGGCGATTCCTCCGAGGTGGACATCCTGGAGTCGGATGGTGGAGCGGGGGCGACGGGCGAGGATCTGGACCATGTGGCAGCCGAGAATTTGATCTTTATGGCGCGTGACGGCCAGCTGAGCGAAATAATGGCGGCCAACGAGGCGGGCGGAACGGTCCTGGTCACCGCCGATGGCACCACGGTGGCCTATGCGGAATCCTTCGACGACGATGCCCAAGTGGTCACCGAGGAGGTCATCACGGACGATTGGGTGCAGCACCAGGGCGCCGAGCGAGTGGAAATCGCCGCGGAGCAGATAGCTGGGATCAGTAGCTCACAGGAATTGCTGGACATGGAGCAGGATCAGTACACTACGTTGAGGCCCTATCCCTGCGACTTTTGCAGCCGTCGCTTTCGGAAGAAGGCCACGTTGAACAACCACATGCTGGCCCACCAGAATGACCGACCGCATCTCTGCAAGCTGTGTGGAGCGCGGTTCTCTCGCCGGGCCGAGCTCATCAGTCACTTTAAGGCCCACGCAGAGGCCCAAGATGCAGCCGATGCCGAGGCAGCGGCCGCCGCAGCCGATTCCTCTTCCGCCATCAAGTTTGAGCATCAGTCGCAGCGACAGCTGGACGATCACTATTACGAGCAGGACTGGCCACTctaccagcagcagcaggaacaGGAGCAGGCGCAACAGGAGATGCAGCAGCATCATCAGATCGTGGATGAGAGCGAGGTTCAGCTGGTGTCCAGCTATCCGGCCACCGTGATCCCACCAGCAGCTCCGTCGCGGGGCAGAATCAGTCGGCTGAAGCCCAAGGAGGAGAGCAGCCAGTTCATCGTGATTTCCGACAAGCCAGCGGTCACCGAGTTGAGGCAGTACATGGAGGCTGATGCGTCTCAGCCTGTGGTCACCACGTCGCAGCCCATTGCCGTCGACCCGCCTCCTCAACCAATCTTTCCGGTGCTGGACGACAGCAAACCCTTTGTTTGCCAGCAGTGCGGATTGGCCTTTGCGCGGGAAAAGGCACTCGTCTCACACACGAAGAACCACCGCGTGGACTCGCCCTTCGAGTGCAACCAGTGCCAGGAGATGTTCTGGGACAACACCAGCCTACAGGAACACCAGAAGACGCATCAGTTCGAGGAGAGTAACTCGGAGTACGATCCTGCCTCGGCAGAGGATAGCGCCAGCGAATCGGAAAACGAGGAGCAGTTGTATGGCGAGTTCTATTGCTACGAATGCGGGATTTCTTTCCATCGCCAGGATCTGCTTCGACGCCATGCCAAGATGCACTACAAGGAAACGGATCAGGCAGCCGGCGAGAGCAATTCCGATGTCACTGCTGGCGGTGATGTGGAGATTGCCAAAGATTCTACGGGTCACTCTTGTACCACATGCGGAAAGTCCTTCCCCAGCGCTTTGGAGATGCTCGCCCATGCCGAGATCCACGCTCGGTTCCCGCCTTTCAAGTGCGTCCTATGCGGAATTAGCTTTTACGAGGAGCAGGCAATCAAGCGGCACCTGCACACCCGCCACCCCACTGAACTGAAGGCCAACTCCTGCGTGCTGTGCGGCAAGGAGTGCCGCGATCGCAAGGCTCTGATTAAGCACGCCTGGGACCATTCGCGCGAGAAGTGCCATTCGTGCTCCAAATGCGGCAAGAACTTCCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGCGACAAGTCGGTGGTATGCGAGGTGTGCCAGGAGGAATTCCCCGACGGACGAACGCTCTCCAACCACCGGCACTCGCACAGCACCACCTCACCGGGCAAGCTGTTTCCGTGCCACGAGTGTGGCAAGACCTTTGGATCACGTAGCTCCCAGCAGATCCACGTCCGCATTCACACTGGAGAGCGTCCATATGGCTGTCGCTACTGCTGGAAGGCCTTCGCTGATGGTGGTACGCTGCGCAAGCACGAGCGGATCCACACGGGCGAGAAGCCCTACGCCTGTTCAGTCTGTCCGCGTGCCTTTAATCAACGGGTGGTGCTGCGGGAACACATCCGCTCCCATCATTCTGGTCTGGATGTGGCGCGAAATACGTACCACTGCACGGTCTGCTCCGAGGACCTGGCCTCGTCCAATGACCTCATCCAGCACCTTATCCAACACAGTGACTCCAACACCGCCAAGCAGCGGCAACCCATTACGGGGCCGCGCAAGTACAAGCGTCGACGTAAACTGCAGCCGTTCGAGATTGCTCACATGCGTGCATCGCACAACGAGGCAAACGGCGAAGAGGAGGAGGCCACTGGAGATGGTGAAGCCGAGGAGTATGCCAGTGACATCGACCTTTGCGACTTTGATGTGGAGAATGTGGACGATCTGTTTGACATGGCCGAGTCGCCCAAGAAGGAGAAGCGAAAGAGGGGATCGACAGCCCCGAAGGCTGATTCTAAACCCATGACCAATGGCAAAGCGGTGAAAGCTGCCCAGGAAAAGAGCAAAGCCAAGCCGAGATATGACTCCACCAGCAGTCAGCAATCAGATCGCATCTGGGAGGAGAAGTTTATGCACGACAGCCAAGTGGGTCTCTTTCAAATCGATTCGCTGGTGGTGGTCAACGATACGCATCTGCAGCCTGCCACCTCCACTGGGTCTTTAGGCGTACCCAACACAAGAGCTGGTGCCAAGCAGCAGGCAAAACTGCAGGCAAAATCAGCAGAAGGAGCTGGATCTTTCAACAACTCCTCTGCCACATCTGTTTCCACATCGTCTGCCTCCACTTCTAGCAGTCGCAGCAGGAAGAAGGCAGCAACCAACAAGACTGCCAACAAAGCACCACCTGCCAGCAATTCGCGACCCCGAATGATTCACACAGAGAAGGCCAAGGTGACGAGGGGCGCTAGCGGAGACTCCTCTGGCAGTGCGGCTAAGAAGTCGCGCTCCAAGACCTACATTAGTCGCACGGAGACCAGTAATCTGAGCCTGGACAAGTCCCGCAGCAGTGCCTCAAACATGGTGGATGACTATGAGATCATTTCTCCAGCCACTCATCCACCGAATCAAATCAGCTCCAGCCCCTTGCATATAAAACAGGaacaggagcagcagcagcgggtCCAGCTGATGTACGATGATAATCTGCTGATAGATGCTGCTTTGCTTAGGGAGAAGACGTACGACCTGGAGCAGATTTTGCGCTCGCCACTGAAACACGAGAGGAACTCCCGTCTACGCTTTACCAGCGAATCTTCAATCACCCCACAGTTTTTGCCTGAGGAAGAGCAAAATCTGATCAAGATCGAGCCAACATCTCCTGATTTGCGGGAGATGGTGGAGAGTCAGCAGAGGGTCACTGCTCATAGTGGGAGCACTCCGtcgtcgtcctcctcctctGCCAGAACTTCCAGACATCTGCGACAGATCACTGCCAATGGAACACGGGCAGGAAGCAAAAGATCTGCGGGAGACGTGGCCAGCAAATCGTCACAGGCTCCTGGTGCAGCGTCCAAAAAAGCTAACACTGCCACCAAGGTCAGCAGTAGCTCATCCTCCTCCTACCTCAGTTACGGGGTAGATTCTTACAACGTAAACGTACCTGCCAGCGCCAACAATGCCGATGTGGGTGGTGGATTCTTTTCCATCTCGGAGGTCGTGTCCGCAGCCGATGCCGCGGATGCGGCTGCGAAGGCAGCGGCAGCTGGTAAATCGGAGCGGAAAACCCGCAGCTTCGAGTGCGAAATGTGCTCGGCCATCTTTTATGATCGAGCCCAACTGCTGGAACATGTACACATCCACATTTAG
Protein Sequence: MNNQRYGGIQWIQHHVSAGDSSEVDILESDGGAGATGEDLDHVAAENLIFMARDGQLSEIMAANEAGGTVLVTADGTTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDQYTTLRPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQSQRQLDDHYYEQDWPLYQQQQEQEQAQQEMQQHHQIVDESEVQLVSSYPATVIPPAAPSRGRISRLKPKEESSQFIVISDKPAVTELRQYMEADASQPVVTTSQPIAVDPPPQPIFPVLDDSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNTSLQEHQKTHQFEESNSEYDPASAEDSASESENEEQLYGEFYCYECGISFHRQDLLRRHAKMHYKETDQAAGESNSDVTAGGDVEIAKDSTGHSCTTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPTELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPFEIAHMRASHNEANGEEEEATGDGEAEEYASDIDLCDFDVENVDDLFDMAESPKKEKRKRGSTAPKADSKPMTNGKAVKAAQEKSKAKPRYDSTSSQQSDRIWEEKFMHDSQVGLFQIDSLVVVNDTHLQPATSTGSLGVPNTRAGAKQQAKLQAKSAEGAGSFNNSSATSVSTSSASTSSSRSRKKAATNKTANKAPPASNSRPRMIHTEKAKVTRGASGDSSGSAAKKSRSKTYISRTETSNLSLDKSRSSASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYDLEQILRSPLKHERNSRLRFTSESSITPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTAHSGSTPSSSSSSARTSRHLRQITANGTRAGSKRSAGDVASKSSQAPGAASKKANTATKVSSSSSSSYLSYGVDSYNVNVPASANNADVGGGFFSISEVVSAADAADAAAKAAAAGKSERKTRSFECEMCSAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00605719;
90% Identity: iTF_00581679;
80% Identity: -