Dtak004961.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila takahashii
Gene Symbol
lov
Assembly
GCA_018152695.1
Location
JAECXN010000110.1:10509166-10518457[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.1e-24 4.4e-22 78.1 0.0 1 100 128 223 128 228 0.94

Sequence Information

Coding Sequence
ATGTTAAAGGACGCCGACCAGGAGTTGATTAAACGTCGCCAACAGACGACGCTCCCCATGACCGACTTCGCTCGTCAGGTGGCGCCCGTTCAGCTGCCTCTGCCTCTGTCTATGCCGCTACCGCTTTTGGCCAAAACACCGACTACCGATCACGCCCCCATGCACTCCACGCCCCCCACGACGCCGCCCACACCGCCACCTCTGCCCCTAAACATGAGTCAAGCGGCAACGGCGGCAGCCACAGAAGCGGCGACTCCCTCAGAGCACAGTCCACCTGCCACGCCCCCCTCAGGGGGAGCAGGGGCACCAGGTGCAATCGCGGCCCCACAGGATCACTACAGCCTGCGCTGGAACAACCATCAGAATCACATCCTGCGAGCCTTCGATGCACTGCTGCAGACCAAGACGCTGGTGGACGTGACCCTGGTCTGCGCAGAGACCTCGATCCGGGCCCACAAAATGGTGCTTTCCGCCTGCTCGCCCTTCTTCCAGCGCGTCTTCGCGGAGACGCCCTGCAAGCATCCGGTTATCGTGCTCAAGGACTTCCGGGGCTGGGTGGTGCAGGCCATCGTGGACTTCATGTACCGCGGCGAGATCAGCGTCCCGCAGCGGCGTCTCCAGACCCTAATTCAGGCGGGAGAGTCGCTTCAAGTGCGGGGTTTGGTGGAGAGCTCAGTGCCGGAGCACACGCCCACGCCAGCCGCCTCGCCCGATGACTTTGACATGATGGAAGCATCGATGCTGTCCTCCAGCTTCGAGGACGAGTCGCCGTCAATGGTCCGACCATCGACGGCCGGGAAGCTAATGATGCCCTCCGCCTCCGCCCGACTGTTCGGCAACGCGTCGAACGCCATGGCAGCGCTAAGTCTCCGACGAAAGCGGGAGCCGGATTGCGACCGCGAGATGGAGAGCGACCAGGAGCTGGGTGGGAGTTCGCCCATGCCCCGACGCAAGCAAGCCCGACCACGCCGTCGATCCGGCGATGTTCCCCACGACTTTGCCCTGAACAAGACCGATACCGAATCCTTGCAAACTGTGATCAAGCACGAGCTGCTCGAACGAGCGGATAGGGATCACGACGACGAGGATCATGATCGAGAAGCAGAGAAAAACGGTTCCTCGCCAGCGGAAACGTCGATGGACCAGGCCAAGGAGAAGCAGTCGCTGAAGCCAGAAGTACCCGATCAACCCCTCAACCCCAACGATAGCCACCATCGGCTCGAGCTGGACGATGAGGACGACGACGACGATCAGGATCGGGATCACGAGGAGGAGGAGGAGGAGCAGGACATTGAAGAGCTTATTCACACGACCAACGAGCTGAGGCGTCAGGCTGCCGCAGCTGCTGCCAATGCGGCCGCCATGTCGCCCGTCCCCTCGCCCTGTCCCAGCGACGGGCCCGAGGACCTCTGCACCACAAAGAAGGCCAAGGACGGCAACACCAGTGTCACCCACTCCTCCGACTGTGAGTCCAACAACAACAACAACAGCAGCAAGCTGCAGGACAACAACCAACGCATAATGCTGTCCCTAAAGGACATACGCCAACTAAACGCCAATCCGAACCCCACAGCCATCCACACGCCCACCAGCTGCTCCGGCGGCAACAACGGACTGCTTAGCTTTCCGCCGCCAGGACTTCGACCACCAGGACTCCCAGACAGCCCGCCCTGCCACATGGAAGCCCTTGAAGCGCAGATGCACGCTGCCGCGGCTGCGGCCGTCGCTGCAGCCGGAGCCGGGGAACATCCCTTCCACCACATGGAGCACCAGATGGAGATGTCCTTGGCGGCAGCAGCGGCTGCGGCTGCAATGCATCAGCGGGAGCCCCGAGATCCCCGTGATCCGCGCGACCACAACGCATTCGCCAGCAATCTGCTGGGACCCATGGGGATGCCCCCCTTCGGAGGACATAACGGCGGTCATCCGGGCAGCGGTGGTCCAGGAAACGGATGTTCGGGACAGGCTGCGCACGAACGGCTCGAGGAGAGCATGAATCGACTGAGCAAGGAGCTTGGCAAGGAGTTCGGCAAGGACTTTGGCAAGGAGTTCGGGAAGGAGTTTGCCCCGGCATCGCCGATGAGTTTGCCGGGACACTTCAATGCACCGGATGGACCTCCGCATCCGCCGTCACCACTGCCCTTTCCCGGCATGTCCTCTGCGATGACTCTGACGCCGCCGCACATGTTTGGCCTGGACTCCCCACTCGGACTCTTTCCACCCGGAATGGATCCTGGCAAGCTCTACAACCCACTAATGGAAATGAGCGATCCAAGGGACATGCCTGGCGGCCCGCCACCGTTTCTTAAGAAGAAAATGCCACGACCAAAGGGACAACACTCGGCTCCCCGCGGCGGTCCTCCGCGCTCCTGGACCAACACAGAACTGACGGAGGCCCTGCAGCACGTGTGGAACAAGAAGATGACCACGTCGCAGGCCTCGCGCATCTTCGGCATCCCCTACAACTCCCTACTCATGTACGTGCGGGGCAAGTATGGCAAGAGCTTGAAGCTGGAACAGCTGCGCAAGGACTGCATCAGTGGACCACCGATCGAGATGTTGCAGATGGGGATCGGCGGAAATAGCGGGGGCGGAGGCGGCTCCAATAAGAGCGAGAAGAGCAAGGAGCGCAAGGAGAAGGAGAAGGACAAAAACTCCGGCGGCAACAACGGCTCGGGTGGGTCGAACAATAGCCAAGGCCCTTCGTCTGGCAACGGATCTTCAATGCCACATCCCGGTGATGGAATGGGCCCCTTGGGTCCGCTGGATCTGGAGCTGGGTCTTCCCCTAGGACCACCTGGCGGCCCACGCAGCGGCAGCTCCGAGCCGGATCTGCTAAGCGGCCCCAACGCCCTCTTCAATCCCTTCAACCCGCAGGGCTTCTACCCGGACTTTTCCGGAGGCTTTCCCGGCCTCCCCCTGAGCATGCTGAACCTGCTGCCACCGGCGGAGCGCCATCATGCAGCGGCTGCCATGCATCACCTGGGCGTGACCATGGACGAGGACTGCAAGTCTGTGGGATCGAAGCAGTCCTCGTCCATGGACGATGACTTTGCGGGCCCAGGGATGCCCCTGTCGCTGGAGCAGCGTCGGGAGATGAGTGCGACAGGCCCACCACTGACTCAGTCGAACGGCGGAGCTGGGCAGGATTGA
Protein Sequence
MLKDADQELIKRRQQTTLPMTDFARQVAPVQLPLPLSMPLPLLAKTPTTDHAPMHSTPPTTPPTPPPLPLNMSQAATAAATEAATPSEHSPPATPPSGGAGAPGAIAAPQDHYSLRWNNHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQRRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFDMMEASMLSSSFEDESPSMVRPSTAGKLMMPSASARLFGNASNAMAALSLRRKREPDCDREMESDQELGGSSPMPRRKQARPRRRSGDVPHDFALNKTDTESLQTVIKHELLERADRDHDDEDHDREAEKNGSSPAETSMDQAKEKQSLKPEVPDQPLNPNDSHHRLELDDEDDDDDQDRDHEEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPVPSPCPSDGPEDLCTTKKAKDGNTSVTHSSDCESNNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLSFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGAGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDPRDHNAFASNLLGPMGMPPFGGHNGGHPGSGGPGNGCSGQAAHERLEESMNRLSKELGKEFGKDFGKEFGKEFAPASPMSLPGHFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGMDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGNSGGGGGSNKSEKSKERKEKEKDKNSGGNNGSGGSNNSQGPSSGNGSSMPHPGDGMGPLGPLDLELGLPLGPPGGPRSGSSEPDLLSGPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVTMDEDCKSVGSKQSSSMDDDFAGPGMPLSLEQRREMSATGPPLTQSNGGAGQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00605496; iTF_00546049; iTF_00545890; iTF_00503913; iTF_00504074; iTF_00615650; iTF_00615489; iTF_00539045; iTF_00538881; iTF_00614830; iTF_00614989; iTF_00487923; iTF_00488100; iTF_00580059; iTF_00579905; iTF_00566173; iTF_00566004; iTF_00504610; iTF_00619076; iTF_00504773; iTF_00619231; iTF_00596737; iTF_00539741; iTF_00596573; iTF_00539583; iTF_00591623; iTF_00591778; iTF_00592316; iTF_00592472; iTF_00541157; iTF_00540996; iTF_00517799; iTF_00517634; iTF_00594631; iTF_00594469; iTF_00491594; iTF_00491434; iTF_00476011; iTF_00477415; iTF_00477263; iTF_00475859; iTF_00550332; iTF_00550178; iTF_00488747; iTF_00488587; iTF_00611435; iTF_00611275; iTF_00525806; iTF_00569768; iTF_00569614; iTF_00525950; iTF_00571982; iTF_00571821; iTF_00603438; iTF_00603269; iTF_00484368; iTF_00484522; iTF_00507536; iTF_00507693; iTF_00563824; iTF_00564008; iTF_00505489; iTF_00505326; iTF_00480786; iTF_00480944; iTF_00489299; iTF_00489458; iTF_00524340; iTF_00524495; iTF_00565461; iTF_00565297; iTF_00477942; iTF_00478101; iTF_00561846; iTF_00561681; iTF_00601142; iTF_00600978; iTF_00617559; iTF_00617734; iTF_00613429; iTF_00490001; iTF_00490163; iTF_00492154; iTF_00492316; iTF_00487384; iTF_00487221; iTF_00578456; iTF_00578632; iTF_00533177; iTF_00533025; iTF_00548153; iTF_00547988; iTF_00471706; iTF_00471537; iTF_00536858; iTF_00536688; iTF_00581626; iTF_00581456; iTF_00481467; iTF_00481624; iTF_00474428; iTF_00474584; iTF_00480092; iTF_00531580; iTF_00480253; iTF_00531744; iTF_00590164; iTF_00590320; iTF_00482904; iTF_00609250; iTF_00609094; iTF_00483066; iTF_00486492; iTF_00486648; iTF_00602684; iTF_00602506; iTF_00514813; iTF_00514977; iTF_00527230; iTF_00527387; iTF_00515519; iTF_00515675; iTF_00593919; iTF_00593759; iTF_00612735; iTF_00612898;
90% Identity
iTF_00602684;
80% Identity
iTF_00605496;