BTB
- Domain
- zf-C2H2|ZBTB
- Group
- Zinc-Coordinating Group
- PFAM
- PF00651
- Desciption
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Rederence
-
- The POZ domain: a conserved protein-protein interaction motif. Bardwell VJ, Treisman R. Genes Dev. 8, 1664-77, (1994).
- Crystal structure of the BTB domain from PLZF. Ahmad KF, Engel CK, Prive GG. Proc. Natl. Acad. Sci. U.S.A. 95, 12123-8, (1998).
- The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Huynh KD, Bardwell VJ. Oncogene 17, 2473-84, (1998).
- Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. Wong CW, Privalsky ML. J. Biol. Chem. 273, 27695-702, (1998).
- The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S, Lantoine D, Kerckaert JP, Leprince D. Cell Growth Differ. 6, 1495-503, (1995).
- The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Zollman S, Godt D, Prive GG, Couderc JL, Laski FA. Proc. Natl. Acad. Sci. U.S.A. 91, 10717-21, (1994).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000480 | Abrostola tripartita | Atri009485.1 | - |
| iTF_00000438 | Abrostola tripartita | Atri010608.1 | dbo |
| iTF_00000439 | Abrostola tripartita | Atri000540.1 | Lztr1 |
| iTF_00000440 | Abrostola tripartita | Atri015976.1 | rdx |
| iTF_00000441 | Abrostola tripartita | Atri020458.1 | ttk |
| iTF_00000442 | Abrostola tripartita | Atri011041.1 | lolal |
| iTF_00000443 | Abrostola tripartita | Atri008291.1 | KLHL5 |
| iTF_00000444 | Abrostola tripartita | Atri018277.1 | KEAP1 |
| iTF_00000445 | Abrostola tripartita | Atri017231.1 | lola |
| iTF_00000446 | Abrostola tripartita | Atri018483.1 | br |
| iTF_00000447 | Abrostola tripartita | Atri002572.1 | lolal |
| iTF_00000448 | Abrostola tripartita | Atri009632.1 | ab |
| iTF_00000449 | Abrostola tripartita | Atri012963.1 | br |
| iTF_00000474 | Abrostola tripartita | Atri005603.1 | bab2 |
| iTF_00000450 | Abrostola tripartita | Atri017550.1 | mod(mdg4) |
| iTF_00000451 | Abrostola tripartita | Atri003506.1 | bab2 |
| iTF_00000452 | Abrostola tripartita | Atri010057.1 | br |
| iTF_00000453 | Abrostola tripartita | Atri004368.1 | lolal |
| iTF_00000462 | Abrostola tripartita | Atri006431.1 | Ibtk |
| iTF_00000454 | Abrostola tripartita | Atri004476.1 | mod(mdg4) |
| iTF_00000455 | Abrostola tripartita | Atri009472.1 | BTBD2 |
| iTF_00000456 | Abrostola tripartita | Atri017761.1 | mod(mdg4) |
| iTF_00000457 | Abrostola tripartita | Atri022159.1 | Btbd3 |
| iTF_00000468 | Abrostola tripartita | Atri005751.1 | kel |
| iTF_00000458 | Abrostola tripartita | Atri017639.1 | fru |
| iTF_00000459 | Abrostola tripartita | Atri016651.1 | Klhl10 |
| iTF_00000460 | Abrostola tripartita | Atri003260.1 | Btbd9 |
| iTF_00000461 | Abrostola tripartita | Atri016221.1 | ttk |
| iTF_00000463 | Abrostola tripartita | Atri021392.1 | KLHL10 |
| iTF_00000464 | Abrostola tripartita | Atri001953.1 | RHOBTB1 |
| iTF_00000465 | Abrostola tripartita | Atri002860.1 | IPP |
| iTF_00000466 | Abrostola tripartita | Atri010437.1 | bab2 |
| iTF_00000467 | Abrostola tripartita | Atri010556.1 | At2g30600/At2g30610 |
| iTF_00000469 | Abrostola tripartita | Atri019919.1 | spopla |
| iTF_00000470 | Abrostola tripartita | Atri015309.1 | bab1 |
| iTF_00000471 | Abrostola tripartita | Atri019636.1 | Spopl |
| iTF_00000472 | Abrostola tripartita | Atri005196.1 | lov |
| iTF_00000473 | Abrostola tripartita | Atri014462.1 | ttk |
| iTF_00000475 | Abrostola tripartita | Atri021517.1 | fru |
| iTF_00000476 | Abrostola tripartita | Atri017939.1 | - |
| iTF_00000477 | Abrostola tripartita | Atri016055.1 | - |
| iTF_00000478 | Abrostola tripartita | Atri021521.1 | mod(mdg4) |
| iTF_00000479 | Abrostola tripartita | Atri018211.1 | lov |
| iTF_00000481 | Abrostola tripartita | Atri012503.1 | gprs |
| iTF_00000482 | Abrostola tripartita | Atri007491.1 | lola |
| iTF_00000483 | Abrostola tripartita | Atri018464.1 | - |
| iTF_00000484 | Abrostola tripartita | Atri021185.1 | lola |
| iTF_00000485 | Abrostola tripartita | Atri009704.1 | chinmo |
| iTF_00000486 | Abrostola tripartita | Atri009368.1 | Cp190 |
| iTF_00000487 | Abrostola tripartita | Atri022191.1 | klhl30 |
| iTF_00000488 | Abrostola tripartita | Atri019921.1 | - |
| iTF_00000489 | Abrostola tripartita | Atri011281.1 | Klhl2 |
| iTF_00000490 | Abrostola tripartita | Atri007273.1 | fru |
| iTF_00000491 | Abrostola tripartita | Atri015694.1 | ABTB2 |
| iTF_00000492 | Abrostola tripartita | Atri003813.1 | BTBD8 |
| iTF_00000493 | Abrostola tripartita | Atri012083.1 | ken |
| iTF_00000494 | Abrostola tripartita | Atri006829.1 | - |
| iTF_00000495 | Abrostola tripartita | Atri001405.1 | RAP1GAP |
| iTF_00000496 | Abrostola tripartita | Atri016749.1 | - |
| iTF_00000497 | Abrostola tripartita | Atri002630.1 | - |
| iTF_00000498 | Abrostola tripartita | Atri004555.1 | Btbd7 |
| iTF_00000499 | Abrostola tripartita | Atri000310.1 | Ankfy1 |
| iTF_00000500 | Abrostola tripartita | Atri012751.1 | Armc5 |
| iTF_00000501 | Abrostola tripartita | Atri017255.1 | BTBD19 |