Basic Information

Gene Symbol
MBD2
Assembly
GCA_951799405.1
Location
OX637337.1:3152538-3160059[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.7e-27 4.3e-23 81.2 0.6 1 59 5 78 5 147 0.86

Sequence Information

Coding Sequence
ATGAATATTTCCatagaaaaaaagaaaactgaTTGCACTGCTCTACCCAAAGGATGGCAAAGAGAAGAGGTTTTGAGGAAATCGGGTCTGTCCGCCGGAAAAGTTGATGTGTATTACTACAGTCCGTCGGGCAAGAAGTTCCGCAGCAAGCCGCAGCTGGCGCGCTACCTCGGGGACAGCCTGGACCTCGCTAGTTTCCACTTCCAGAACGGCCGCCTAAACTCCCACAAAAGCCACAGGCTGCGCAACACACAGTTTGACTACAGTCGTGGCGTGAGGTCGGACGCCTCGTTGGTGCCGCCCATCAGACAGACGGCGTCCATCTTCAAGCAGCCGGTGACGGTGCACAAGACGCAGGAGAGCAAAGTGAAGACAGATCTGAAGCACGGGCCGCAGGATAAGCCCAAGCAACTCTTCTGGGAGAAACGCCTTGAgGGTTTGAATGCCTGTGACTCATGGGGCGTCCTGGGAGGAGCGTCCCTGCCCAGGGGGATCAAGTCCATAGGTCCGCACATCAGTGACGCCACCACCATACAGGCACTCGCCACAGCTCTGCACATCACGCCACAACCCGTCACAGGTCAAAGTGTCGCAGCCAAAGCACAGATCGCCCAGAACCCCGGCGTCTTCTTGAACCCGGAGCAGCCGCTGGTGCAGGCGGTGAGCGTGGCAGAGGAGGACATCAGGAGGCAGGAGGAGAGAGTCAACAGGGCACGCAGAAAACTGCAGGAGGCCCTCGGGGTCTGCAGCCAGGATGTCATCAAAGTCTAA
Protein Sequence
MNISIEKKKTDCTALPKGWQREEVLRKSGLSAGKVDVYYYSPSGKKFRSKPQLARYLGDSLDLASFHFQNGRLNSHKSHRLRNTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVHKTQESKVKTDLKHGPQDKPKQLFWEKRLEGLNACDSWGVLGGASLPRGIKSIGPHISDATTIQALATALHITPQPVTGQSVAAKAQIAQNPGVFLNPEQPLVQAVSVAEEDIRRQEERVNRARRKLQEALGVCSQDVIKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2