Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1e-27 6.2e-24 83.8 0.1 2 73 6 72 5 75 0.94

2 2 0.0011 6.5 6.9 0.0 28 72 89 146 77 150 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1e-27	6.2e-24	83.8	0.1	2	73	6	72	5	75	0.94
2	2	0.0011	6.5	6.9	0.0	28	72	89	146	77	150	0.73

Coding Sequence: ATGAGCATCACGGTCGAAAGAAAGAAGACGGACTGCTCGGCGCTGCCGAAGGGATGGCAGCGCGAGGAGGTGCTTCGAAAATCCGGCTTGTCCGCCGGAAAAGTCGACGTTTACTACTACAGTCCGTCTGGTAAAAAGTTTCGCAGCAAACCACAGCTGGCACGATACCTCGGAGACAGCTTGGATCTTGCTTGTTTTGATTTTCAACAGGGGCGCCTTAACTCCCTGTTGCTACGGAAAAATAGAAAACCACGCGGCACACAGTTCGATTACAGCCGAGGAGTTCGCTCCGACGCTTCCCTAGTGCCACCGATACGCCAGACGGCCTCCATATTCAAGCAACCCGTGACGGTTCACAAAACGCAAGAGAGCAAAGTGAAAACGGACTTTAAGCAGGGGCCTCAAGATAAACCGAGGCAGTTATTTTGGGAGAAACGACTGGAGGGTTTGAGCGCGTGCGACGCGTGGGGCGTTCTAGGCGGCGCTTCGCTTCCCAGAGGGATCAAATCGATCGGTCCGCATATAAACGAAGCGACGACGATTCAAGCTTTGGCTACGGCCCTTCACGTGACGCCGAGACCCGTGACAGGTCAAACGGCCTCGAAAACGTCCATATCACAAAATCCCGGGGTGTTCGTCAATCCCGAGCAGCCTTTAGTCCAAGCGGTCAGCGTCGTGGAAGATGACATCAGACGGCAAGAAGAGAGGGTGAACAGAGCGAGAAAAAGACTACAAGAGGCCCTCGTCGGCATGTAg
Protein Sequence: MSITVERKKTDCSALPKGWQREEVLRKSGLSAGKVDVYYYSPSGKKFRSKPQLARYLGDSLDLACFDFQQGRLNSLLLRKNRKPRGTQFDYSRGVRSDASLVPPIRQTASIFKQPVTVHKTQESKVKTDFKQGPQDKPRQLFWEKRLEGLSACDAWGVLGGASLPRGIKSIGPHINEATTIQALATALHVTPRPVTGQTASKTSISQNPGVFVNPEQPLVQAVSVVEDDIRRQEERVNRARKRLQEALVGM

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00023790;
90% Identity: iTF_00815808; iTF_00675141; iTF_00815105; iTF_01366980; iTF_01012304; iTF_00897812; iTF_01086303; iTF_00799276; iTF_00800194; iTF_00800976;
80% Identity: -